Výsledky vyhledávání - "E. Mühlbauer"

Akademický článek

Design of buried charged networks in artificial proteins

Autor: Mona Baumgart, Michael Röpke, Max E. Mühlbauer, Sam Asami, Sophie L. Mader, Kai Fredriksson, Michael Groll, Ana P. Gamiz-Hernandez, Ville R. I. Kaila

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)

Buried charged networks in proteins are often important for their biological functionality and are believed to destabilise the protein fold. Here, the authors combine computational design, MD simulations, biophysical experiments, NMR and X-ray crysta

Externí odkaz: https://doaj.org/article/0e77cdff4a874a32b8c39f0694e34a3c

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Akademický článek

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Deactivation blocks proton pathways in the mitochondrial complex I

Autor: Michael, Röpke, Daniel, Riepl, Patricia, Saura, Andrea, Di Luca, Max E, Mühlbauer, Alexander, Jussupow, Ana P, Gamiz-Hernandez, Ville R I, Kaila

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America

Significance The electron transport chain of mitochondria is initiated by the respiratory complex I that converts chemical energy into a proton motive force to power synthesis of adenosine triphosphate. On a chemical level, complex I catalyzes elemen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e145b9a55597deec9896a8559dac8a28
https://pubmed.ncbi.nlm.nih.gov/34272275

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Design of buried charged networks in artificial proteins

Autor: Ana P. Gamiz-Hernandez, Kai Fredriksson, Ville R. I. Kaila, Sam Asami, Mona Baumgart, Michael Groll, Max E. Mühlbauer, Sophie L. Mader, Michael Röpke

Publikováno v: Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)

Soluble proteins are universally packed with a hydrophobic core and a polar surface that drive the protein folding process. Yet charged networks within the central protein core are often indispensable for the biological function. Here, we show that n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4109cbb56dac341d3771dfe036a72f6
https://doi.org/10.1038/s41467-021-21909-7

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[Ambulatory monitoring and digital phenotyping in the diagnostics and treatment of bipolar disorders]

Autor: E, Severus, U, Ebner-Priemer, F, Beier, E, Mühlbauer, P, Ritter, H, Hill, M, Bauer

Publikováno v: Der Nervenarzt. 90(12)

Reliable and valid diagnostics and treatment of bipolar disorders and affective episodes are subject to extensive, especially methodological limitations in the clinical practice.The use of smartphones and mobile sensor technology for improvement in d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9826b4a732137890b6c5332077db3dc8
https://pubmed.ncbi.nlm.nih.gov/31748866

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Akademický článek

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The insulin–melatonin antagonism: studies in the LEW.1AR1-iddm rat (an animal model of human type 1 diabetes mellitus)

Autor: E Mühlbauer, Elmar Peschke, K Hofmann, Ina Bähr, Dirk Wedekind, S Streck, Elke Albrecht

Publikováno v: Diabetologia. 54:1831-1840

It is well documented that melatonin influences insulin secretion mediated by G-protein-coupled melatonin receptor isoforms MT1 and MT2, which are present in rat and human pancreatic islets, as well as in rat insulinoma cells. Recent investigations h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5197253586973a99a42e3c868a5ef21f
https://doi.org/10.1007/s00125-011-2138-0

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