Zobrazeno 1 - 10
of 781
pro vyhledávání: '"E. Locke"'
Autor:
A. M. O’Hare, K. Berry, V. S. Fan, K. Crothers, M. C. Eastment, J. A. Dominitz, J. A. Shah, P. Green, E. Locke, G. N. Ioannou
Publikováno v:
BMC Geriatrics, Vol 21, Iss 1, Pp 1-10 (2021)
Abstract Background Older age and comorbid burden are both associated with adverse outcomes in SARS-CoV-2, but it is not known whether the association between comorbid burden and adverse outcomes differs in older and younger adults. Objective To comp
Externí odkaz:
https://doaj.org/article/2e70ba3a71de4bfc9f94595c363cd78e
Autor:
Matthew D. Cheung, Rebecca Asiimwe, Elise N. Erman, Christopher F. Fucile, Shanrun Liu, Chiao-Wang Sun, Vidya Sagar Hanumanthu, Harish C. Pal, Emma D. Wright, Gelare Ghajar-Rahimi, Daniel Epstein, Babak J. Orandi, Vineeta Kumar, Douglas J. Anderson, Morgan E. Greene, Markayla Bell, Stefani Yates, Kyle H. Moore, Jennifer LaFontaine, John T. Killian, Gavin Baker, Jackson Perry, Zayd Khan, Rhiannon Reed, Shawn C. Little, Alexander F. Rosenberg, James F. George, Jayme E. Locke, Paige M. Porrett
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Pig-to-human xenotransplantation is rapidly approaching the clinical arena; however, it is unclear which immunomodulatory regimens will effectively control human immune responses to pig xenografts. Here, we transplant a gene-edited pig kidne
Externí odkaz:
https://doaj.org/article/d52c03551ee848b985332f212612900d
Autor:
Parsa Akbari, Olukayode A. Sosina, Jonas Bovijn, Karl Landheer, Jonas B. Nielsen, Minhee Kim, Senem Aykul, Tanima De, Mary E. Haas, George Hindy, Nan Lin, Ian R. Dinsmore, Jonathan Z. Luo, Stefanie Hectors, Benjamin Geraghty, Mary Germino, Lampros Panagis, Prodromos Parasoglou, Johnathon R. Walls, Gabor Halasz, Gurinder S. Atwal, Regeneron Genetics Center, DiscovEHR Collaboration, Marcus Jones, Michelle G. LeBlanc, Christopher D. Still, David J. Carey, Alice Giontella, Marju Orho-Melander, Jaime Berumen, Pablo Kuri-Morales, Jesus Alegre-Díaz, Jason M. Torres, Jonathan R. Emberson, Rory Collins, Daniel J. Rader, Brian Zambrowicz, Andrew J. Murphy, Suganthi Balasubramanian, John D. Overton, Jeffrey G. Reid, Alan R. Shuldiner, Michael Cantor, Goncalo R. Abecasis, Manuel A. R. Ferreira, Mark W. Sleeman, Viktoria Gusarova, Judith Altarejos, Charles Harris, Aris N. Economides, Vincent Idone, Katia Karalis, Giusy Della Gatta, Tooraj Mirshahi, George D. Yancopoulos, Olle Melander, Jonathan Marchini, Roberto Tapia-Conyer, Adam E. Locke, Aris Baras, Niek Verweij, Luca A. Lotta
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Fat distribution is associated with cardiometabolic disease, although it has been less well studied than overall obesity. In a multiancestry exome-sequencing study, the authors identified predicted loss-of-function mutations in INHBE associated with
Externí odkaz:
https://doaj.org/article/9f24eb7300be4033aaf87fbf13407526
Autor:
Xianyong Yin, Lap Sum Chan, Debraj Bose, Anne U. Jackson, Peter VandeHaar, Adam E. Locke, Christian Fuchsberger, Heather M. Stringham, Ryan Welch, Ketian Yu, Lilian Fernandes Silva, Susan K. Service, Daiwei Zhang, Emily C. Hector, Erica Young, Liron Ganel, Indraniel Das, Haley Abel, Michael R. Erdos, Lori L. Bonnycastle, Johanna Kuusisto, Nathan O. Stitziel, Ira M. Hall, Gregory R. Wagner, FinnGen, Jian Kang, Jean Morrison, Charles F. Burant, Francis S. Collins, Samuli Ripatti, Aarno Palotie, Nelson B. Freimer, Karen L. Mohlke, Laura J. Scott, Xiaoquan Wen, Eric B. Fauman, Markku Laakso, Michael Boehnke
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
The Finnish population is enriched for genetic variants which are rare in other populations. Here, the authors find new genetic loci associated with 1391 circulating metabolites in 6136 Finnish men, demonstrating that metabolite genetic associations
Externí odkaz:
https://doaj.org/article/2bfc641ed38244daa7d87b37ef3b16fc
Autor:
Paige M. Porrett, Jayme E. Locke
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 19 (2022)
Externí odkaz:
https://doaj.org/article/e0c24011a7f14943b6886c95bb2a4d7e
Autor:
A Cozette Killian, Rhiannon D Reed, M Chandler McLeod, Paul A MacLennan, Vineeta Kumar, Sydney E Pittman, Andrew G Maynor, Luke A Stanford, Gavin A Baker, Carrie A Schinstock, John R Silkensen, Garrett R Roll, Dorry L Segev, Babak J Orandi, Cora E Lewis, Jayme E Locke
Publikováno v:
PLoS ONE, Vol 17, Iss 11, p e0276882 (2022)
BackgroundApproval of living kidney donors (LKD) with end-stage kidney disease (ESKD) risk factors, such as obesity, has increased. While lifetime ESKD development data are lacking, the study of intermediate outcomes such as diabetes is critical for
Externí odkaz:
https://doaj.org/article/0f2d9dfc92684833b2e7debfb595fdb9
Autor:
Robert M. Cannon, Douglas J. Anderson, Paul MacLennan, Babak J. Orandi, Saulat Sheikh, Vineeta Kumar, Michael J. Hanaway, Jayme E. Locke
Publikováno v:
Annals of surgery. 276(4)
The burden of end-stage kidney disease (ESKD) and kidney transplant rates vary significantly across the United States. This study aims to examine the mismatch between ESKD burden and kidney transplant rates from a perspective of spatial epidemiology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::333394ecb9d3530fb40682594e4d854f
https://pubmed.ncbi.nlm.nih.gov/35837899
https://pubmed.ncbi.nlm.nih.gov/35837899
Autor:
Rhiannon D. Reed, Jayme E. Locke
Publikováno v:
Clinical journal of the American Society of Nephrology : CJASN.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42e08b9139a9c8c8736c364db80a9779
https://pubmed.ncbi.nlm.nih.gov/36122939
https://pubmed.ncbi.nlm.nih.gov/36122939
Autor:
Deirdre Sawinski, Jennifer C. Lai, Sean Pinney, Alice L. Gray, Annette M. Jackson, Darren Stewart, Deborah Jo Levine, Jayme E. Locke, James J. Pomposelli, Matthew G. Hartwig, Shelley A. Hall, Darshana M. Dadhania, Rebecca Cogswell, Richard V. Perez, Jesse D. Schold, Nicole A. Turgeon, Jon Kobashigawa, Jasleen Kukreja, John C. Magee, John Friedewald, John S. Gill, Gabriel Loor, Julie K. Heimbach, Elizabeth C. Verna, Mary Norine Walsh, Norah Terrault, Guiliano Testa, Joshua M. Diamond, Peter P. Reese, Kimberly Brown, Susan Orloff, Maryjane A. Farr, Kim M. Olthoff, Mark Siegler, Nancy Ascher, Sandy Feng, Bruce Kaplan, Elizabeth Pomfret
Publikováno v:
American Journal of Transplantation. 23:316-325
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc16a8f2c88c44183e486663950a18d7
https://doi.org/10.1016/j.ajt.2022.11.008
https://doi.org/10.1016/j.ajt.2022.11.008
Autor:
Gordon E. Locke, Khalid Alrabiah, Tae Kyoung Kim, Jennifer Knox, Raymond Jang, Laura A. Dawson
Publikováno v:
Liver Cancer International. 3:162-166
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c55360474935a4202ec7a4d383bb41f5
https://doi.org/10.1002/lci2.69
https://doi.org/10.1002/lci2.69