Zobrazeno 1 - 10
of 1 867
pro vyhledávání: '"E. Lindner"'
The DEAD-box RNA helicase PfDOZI imposes opposing actions on RNA metabolism in Plasmodium falciparum
Autor:
Hui Min, Xiaoying Liang, Chengqi Wang, Junling Qin, Rachasak Boonhok, Azhar Muneer, Awtum M. Brashear, Xiaolian Li, Allen M. Minns, Swamy Rakesh Adapa, Rays H. Y. Jiang, Gang Ning, Yaming Cao, Scott E. Lindner, Jun Miao, Liwang Cui
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract In malaria parasites, the regulation of mRNA translation, storage and degradation during development and life-stage transitions remains largely unknown. Here, we functionally characterized the DEAD-box RNA helicase PfDOZI in P. falciparum. D
Externí odkaz:
https://doaj.org/article/65f9cfb51bd8495780fbf994ff77ce7e
Autor:
Devanshi R. Patel, Allen M. Minns, Derek G. Sim, Cassandra J. Field, Abigail E. Kerr, Talia A. Heinly, Erin H. Luley, Randall M. Rossi, Carol M. Bator, Ibrahim M. Moustafa, Elizabeth B. Norton, Susan L. Hafenstein, Scott E. Lindner, Troy C. Sutton
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 3 (2024)
ABSTRACTMultiple vaccines have been developed and licensed for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). While these vaccines reduce disease severity, they do not prevent infection. To prevent infection and limit transmission, vac
Externí odkaz:
https://doaj.org/article/55f1a1bf25284935bbdcb7a25dab70bd
Publikováno v:
PLoS Pathogens, Vol 19, Iss 4, p e1011267 (2023)
Externí odkaz:
https://doaj.org/article/8662f3c97917417c9bbed0b0e474c3d0
Autor:
Scott E. Lindner, Kristian E. Swearingen, Melanie J. Shears, Aswathy Sebastian, Michael P. Walker, Erin N. Vrana, Kevin J. Hart, Allen M. Minns, Istvan Albert, Photini Sinnis, Robert L. Moritz, Stefan H. I. Kappe
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-4 (2022)
Externí odkaz:
https://doaj.org/article/1ca482631bb9409da5bdd049a070649e
Publikováno v:
mSphere, Vol 7, Iss 3 (2022)
ABSTRACT Some antimalarial drugs that have lost clinical usefulness have been repurposed for experimental applications. One example is sulfadiazine, an analog of p-aminobenzoic acid (pABA), which inhibits the parasite’s folate synthesis pathway to
Externí odkaz:
https://doaj.org/article/c01f95d1be594eaab67689e998e9314a
Autor:
Abhinay Gontu, Sreenidhi Srinivasan, Eric Salazar, Meera Surendran Nair, Ruth H. Nissly, Denver Greenawalt, Ian M. Bird, Catherine M. Herzog, Matthew J. Ferrari, Indira Poojary, Robab Katani, Scott E. Lindner, Allen M. Minns, Randall Rossi, Paul A. Christensen, Brian Castillo, Jian Chen, Todd N. Eagar, Xin Yi, Picheng Zhao, Christopher Leveque, Randall J. Olsen, David W. Bernard, Jimmy Gollihar, Suresh V. Kuchipudi, James M. Musser, Vivek Kapur
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-9 (2021)
Gontu et al. conducted a longitudinal study in COVID patients in which they assessed the response trajectories of antibodies directed to the SARS-CoV-2 surface spike glycoprotein and in vitro SARS-CoV-2 live virus neutralizing titers. Their measureme
Externí odkaz:
https://doaj.org/article/29e9d16320ed452bba1c23cd05a61b50
Autor:
Ian M Lamb, Kelly T Rios, Anurag Shukla, Avantika I Ahiya, Joanne Morrisey, Joshua C Mell, Scott E Lindner, Michael W Mather, Akhil B Vaidya
Publikováno v:
PLoS ONE, Vol 17, Iss 8, p e0273357 (2022)
Despite ongoing efforts to control malaria infection, progress in lowering the number of deaths and infections appears to have stalled. The continued high incidence of malaria infection and mortality is in part due to emergence of parasites resistant
Externí odkaz:
https://doaj.org/article/934c144d3faf4d9c8ec272aaf4db58ce
Publikováno v:
PLoS Biology, Vol 19, Iss 10, p e3001434 (2021)
Productive transmission of malaria parasites hinges upon the execution of key transcriptional and posttranscriptional regulatory events. While much is now known about how specific transcription factors activate or repress sexual commitment programs,
Externí odkaz:
https://doaj.org/article/cf835f6d34be4b68a135f7221c6c536a
Autor:
Scott E. Lindner, Kristian E. Swearingen, Melanie J. Shears, Michael P. Walker, Erin N. Vrana, Kevin J. Hart, Allen M. Minns, Photini Sinnis, Robert L. Moritz, Stefan H. I. Kappe
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Here, the authors report transcriptomes and proteomes of oocyst sporozoite and salivary gland sporozoite stages in rodent-infectious Plasmodium yoelii parasites and human infectious Plasmodium falciparum parasites and define two waves of translationa
Externí odkaz:
https://doaj.org/article/008124ab714a455090e9902fd95469da
Autor:
Abhinay Gontu, Erika A. Marlin, Santhamani Ramasamy, Sabarinath Neerukonda, Gayatri Anil, Jasmine Morgan, Meysoon Quraishi, Chen Chen, Veda Sheersh Boorla, Ruth H. Nissly, Padmaja Jakka, Shubhada K. Chothe, Abirami Ravichandran, Nishitha Kodali, Saranya Amirthalingam, Lindsey LaBella, Kathleen Kelly, Pazhanivel Natesan, Allen M. Minns, Randall M. Rossi, Jacob R. Werner, Ernest Hovingh, Scott E. Lindner, Deepanker Tewari, Vivek Kapur, Kurt J. Vandegrift, Costas D. Maranas, Meera Surendran Nair, Suresh V. Kuchipudi
Publikováno v:
Viruses, Vol 14, Iss 7, p 1358 (2022)
Multiple domestic and wild animal species are susceptible to SARS-CoV-2 infection. Cattle and swine are susceptible to experimental SARS-CoV-2 infection. The unchecked transmission of SARS-CoV-2 in animal hosts could lead to virus adaptation and the
Externí odkaz:
https://doaj.org/article/7a836521bf7046aa81dd14cc5c03ee9a