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Akademický článek

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Inducible upregulation of oestrogen receptor-beta1 affects oestrogen and tamoxifen responsiveness in MCF7 human breast cancer cells

Autor: Robert P. C. Shiu, J R Davie, M Vendetti, Leigh C. Murphy, E Leygue, A Kemp, K Ung, B Peng, A Lewis

Publikováno v: Journal of molecular endocrinology. 34(2)

To investigate the effect of altered oestrogen receptor (ER)alpha and ERbeta expression on oestrogen and anti-oestrogen action in breast cancer, we have stably expressed an inducible ERbeta1 in MCF7 breast cancer cells. Stably expressing clones were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97fad8f2b16cd8ffefd4533f83de2ea6
https://pubmed.ncbi.nlm.nih.gov/15821116

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Akademický článek

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Altered expression of estrogen receptor coregulators during human breast tumorigenesis

Autor: L C, Murphy, S L, Simon, A, Parkes, E, Leygue, H, Dotzlaw, L, Snell, S, Troup, A, Adeyinka, P H, Watson

Publikováno v: Cancer research. 60(22)

The hypothesis that altered expression of specific coactivators/repressors of the estrogen receptor occurs during human breast tumorigenesis in vivo is examined in this study. Using in situ hybridization and reverse transcription-PCR assays, the expr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::132839417b34a44bfc348fc047f9ec65
https://pubmed.ncbi.nlm.nih.gov/11103781

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Expression of a repressor of estrogen receptor activity in human breast tumors: relationship to some known prognostic markers

Autor: S L, Simon, A, Parkes, E, Leygue, H, Dotzlaw, L, Snell, S, Troup, A, Adeyinka, P H, Watson, L C, Murphy

Publikováno v: Cancer research. 60(11)

The expression of a specific repressor of estrogen receptor activity (REA) was investigated by a semiquantitative reverse transcription-PCR assay in 40 human breast tumor biopsy samples with respect to steroid hormone receptor status and other known

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b358b0c2845fd9d754707654db7f6a80
https://pubmed.ncbi.nlm.nih.gov/10850416

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Expression of the steroid receptor RNA activator in human breast tumors

Autor: E, Leygue, H, Dotzlaw, P H, Watson, L C, Murphy

Publikováno v: Cancer research. 59(17)

The expression of the recently described steroid receptor RNA activator (SRA) was measured by semiquantitative reverse transcription-PCR within 27 independent breast tumors, spanning a wide spectrum of grade and estrogen receptor (ER) and progesteron

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7d13dd8bf9494b3a0ac11f57b493658c
https://pubmed.ncbi.nlm.nih.gov/10485452

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The human orphan receptor PXR messenger RNA is expressed in both normal and neoplastic breast tissue

Autor: H, Dotzlaw, E, Leygue, P, Watson, L C, Murphy

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 5(8)

The expression of PXR mRNA and a variant PXR mRNA, deleted in 111 nucleotides in the ligand-binding domain, was detected by reverse transcription-PCR amplification in both normal and neoplastic human breast tissues. The level of PXR mRNA did not diff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a0258713dc4605efcbbb87f91046195d
https://pubmed.ncbi.nlm.nih.gov/10473093

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Expression of estrogen receptor beta1, beta2, and beta5 messenger RNAs in human breast tissue

Autor: E, Leygue, H, Dotzlaw, P H, Watson, L C, Murphy

Publikováno v: Cancer research. 59(6)

A triple-primer PCR assay was developed, based on the coamplification of estrogen receptor (ER)-beta1, -beta2, and -beta5 cDNAs, to investigate the relative expressions of the corresponding mRNAs in breast cancer lines and in 53 independent breast tu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::154f0eaffbc71a57395791a7d06d12a8
https://pubmed.ncbi.nlm.nih.gov/10096542

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Estrogen receptor-beta messenger RNA expression in human breast tumor biopsies: relationship to steroid receptor status and regulation by progestins

Autor: H, Dotzlaw, E, Leygue, P H, Watson, L C, Murphy

Publikováno v: Cancer research. 59(3)

When the level of estrogen receptor (ER)-beta mRNA in tumors, determined by reverse transcription-PCR, was assessed according to either ER status or PR status alone, determined by ligand binding assays, the level of ER-beta mRNA was significantly low

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::86c1c9cd490faff7f26fc3d09a780c14
https://pubmed.ncbi.nlm.nih.gov/9973194

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