Zobrazeno 1 - 10
of 95
pro vyhledávání: '"E. Lefler"'
Autor:
Michael C. Ostrowski, Catherine MarElia-Bennet, Cynthia J. Timmers, Akiko Koide, John P. O'Bryan, Mariyam Zuberi, Julia E. Lefler, Thierry Pécot, Eric Denbaum, Dean M. Connor, Imran Khan, Ann-Marie Broome, Shohei Koide
Publikováno v:
Small GTPases
RAS is the most frequently mutated oncogene in human cancer with nearly ~20% of cancer patients possessing mutations in one of three RAS genes (K, N or HRAS). However, KRAS is mutated in nearly 90% of pancreatic ductal carcinomas (PDAC). Although pha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22b6e246d4dd430d97346f7a1be535e1
https://doi.org/10.1080/21541248.2021.1906621
https://doi.org/10.1080/21541248.2021.1906621
Publikováno v:
Cancer Research. 83:3643-3643
This study aims to test the hypothesis that direct interactions and auto-regulatory loop between PTEN and STAT3 in cancer-associated fibroblasts (CAFs) contribute to an immunosuppressive tumor microenvironment in pancreatic ductal carcinoma (PDAC). P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5848261ac84d3d9af6aa39e1f7e5ee0
https://doi.org/10.1158/1538-7445.am2023-3643
https://doi.org/10.1158/1538-7445.am2023-3643
Publikováno v:
Advances in cancer research. 154
Decades of research have concluded that disruptions to Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) have profound effects on cancer progression. However, as our understanding of the tumor stroma has evolved, we can appreciate that d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b034af26a2bbc25065a86258c0c409c4
https://pubmed.ncbi.nlm.nih.gov/35459470
https://pubmed.ncbi.nlm.nih.gov/35459470
Publikováno v:
Advances in Cancer Research ISBN: 9780323854238
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9fd8852ff16594ed1b162e9586788cd7
https://doi.org/10.1016/bs.acr.2022.01.002
https://doi.org/10.1016/bs.acr.2022.01.002
Autor:
Sarah Pippin, Michael C. Ostrowski, Anand Mehta, Janet E. Saunders, Lauren E. Ball, Laura Spruill, Peggi M. Angel, Jennifer R. Bethard, Denys Rujchanarong, Julia E. Lefler, Richard R. Drake
Publikováno v:
Cancers, Vol 13, Iss 4419, p 4419 (2021)
Cancers
Volume 13
Issue 17
Cancers
Volume 13
Issue 17
Simple Summary Extracellular matrix within the tumor microenvironment influences signaling, controls molecular diffusion of nutrients and growth factors, alters immunogenicity, and contributes to disease progression and therapeutic response. ECM is s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dcdcc2afdeeaf13f2b111e3f1d8e42d
https://www.mdpi.com/2072-6694/13/17/4419
https://www.mdpi.com/2072-6694/13/17/4419
Autor:
Julia E Lefler, Catherine B MarElia-Bennett, Katie A Thies, Blake E Hildreth, Sudarshana M Sharma, Jason R Pitarresi, Lu Han, Caroline Everett, Christopher Koivisto, Maria C Cuitino, Cynthia D Timmers, Elizabeth O’Quinn, Melodie Parrish, Martin J Romeo, Amanda J Linke, G Aaron Hobbs, Gustavo Leone, Denis C Guttridge, Teresa A Zimmers, Gregory B Lesinski, Michael C Ostrowski
Publikováno v:
Life Science Alliance. 5:e202201460
Pancreatic ductal adenocarcinoma (PDAC) is associated with an incredibly dense stroma, which contributes to its recalcitrance to therapy. Cancer-associated fibroblasts (CAFs) are one of the most abundant cell types within the PDAC stroma and have con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::706720cae3f951f3d2ea699911c997c4
https://doi.org/10.26508/lsa.202201460
https://doi.org/10.26508/lsa.202201460
Autor:
Blake E. Hildreth, Sankha Ghosh, Michael C. Ostrowski, S. Sharma, Julia E. Lefler, Catherine B. MarElia-Bennett
Angiogenesis is a highly orchestrated process involving complex crosstalk between several endothelial cell processes including cell cycle, cell survival and migration. Transcription factors ETS1 and ETS2 are required for EC functions necessary for em
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4791e3ff7fb438a8fdd96f1d84c934dc
https://doi.org/10.1101/2020.02.19.956417
https://doi.org/10.1101/2020.02.19.956417
Publikováno v:
Cancer Research. 81:PO-114
One of the defining characteristics of pancreatic ductal adenocarcinoma (PDAC) is the formation of a dense stroma comprised of cancer associated fibroblasts (CAFs) and immune cell populations. This stroma is immunosuppressive and can act as a physica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::03c618a06d76f55361901d224a6ae61a
https://doi.org/10.1158/1538-7445.panca21-po-114
https://doi.org/10.1158/1538-7445.panca21-po-114
Publikováno v:
Cold Spring Harb Perspect Med
Although tremendous progress has been made in understanding the functions of Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) in tumor cells, only recently have tumor cell-non-autonomous PTEN actions within the tumor microenvironment (T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1598ac212e748ac328ec4739cb7e6e53
https://pubmed.ncbi.nlm.nih.gov/31427286
https://pubmed.ncbi.nlm.nih.gov/31427286
Publikováno v:
Cancer Research. 81:PR002-PR002
One of the defining characteristics of pancreatic ductal adenocarcinoma (PDAC) is the formation of a dense stroma comprised of cancer associated fibroblasts (CAFs) and immune cell populations. This stroma is immunosuppressive and can act as a physica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27423952754f424be013e29441744029
https://doi.org/10.1158/1538-7445.tme21-pr002
https://doi.org/10.1158/1538-7445.tme21-pr002