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pro vyhledávání: '"E. Landgraf"'
Akademický článek
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Autor:
Kyle E Landgraf, Maruti Uppalapati, Qiyang Jiang, Annalise Petriello, Stephen B. H. Kent, Gang Chen, Paul S Marinec, Daniel Xie, Dana Ault-Riche, Sachdev S. Sidhu, Kurt Deshayes, Yanlong Zhao
Publikováno v:
ACS chemical biology. 16(3)
We report a general approach to engineering multivalent d-proteins with antibody-like activities in vivo. Mirror-image phage display and structure-guided design were utilized to create a d-protein that uses receptor mimicry to antagonize vascular end
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e33640 (2012)
The second messenger lipid PIP(3) (phosphatidylinositol-3,4,5-trisphosphate) is generated by the lipid kinase PI3K (phosphoinositide-3-kinase) in the inner leaflet of the plasma membrane, where it regulates a broad array of cell processes by recruiti
Externí odkaz:
https://doaj.org/article/40f9a4962cd34327a99ce0e5fbde6cad
Akademický článek
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Publikováno v:
The FASEB Journal. 34:1-1
Autor:
Kyle E. Landgraf, Clifford Quan, Charles Eigenbrot, Henry R. Maun, Jeffrey Tom, Micah Steffek, Lydia Santell, Robert A. Lazarus, Christine Yu
Publikováno v:
Nature Chemical Biology. 10:567-573
Stimulation of hepatocyte growth factor (HGF) signaling through the Met receptor is an attractive approach for promoting tissue repair and preventing fibrosis. Using structure-guided peptide phage display combined with an activity-based sorting strat
Publikováno v:
Monatshefte. 105:472-488
The article examines Nietzsche’s adoption of Johannes Muller’s principle of specific nerve energies, which Nietzsche expands to encompass the relationship between nerve stimulus, mental image, and language. As a consequence, Nietzsche dispenses w
Publikováno v:
Biochemistry. 50:9845-9856
During the appearance of the signaling lipid PI(3,4,5)P(3), an important subset of pleckstrin homology (PH) domains target signaling proteins to the plasma membrane. To ensure proper pathway regulation, such PI(3,4,5)P(3)-specific PH domains must exc
Autor:
William J. Pettit, Brian E. Whitacre, Chad E. Landgraf, Jeffrey B. Hackler, Matthew Janey, Vicky Pace
Publikováno v:
International Journal of Osteopathic Medicine. 14:17-23
Background Many osteopathic medical schools across the United States seek to produce physicians who will ultimately locate in rural areas. Most of these schools offer courses and programs designed to promote rural location. Objective To explore how m