Zobrazeno 1 - 10
of 25
pro vyhledávání: '"E. L. Vodovozova"'
Publikováno v:
Russian Journal of Bioorganic Chemistry. 49:412-415
Abstract— The ionizable lipid ALC-0315, ((4-hydroxybutyl)azanediyl)bis(hexane-6,1-diyl)bis(2-hexyldecanoate), is a component of the lipid matrix of the prophylactic SARS-CoV-2 mRNA vaccine produced by Pfizer/BioNTech. This lipid ensures efficient v
Autor:
D. S. Tretiakova, A. S. Alekseeva, N. R. Onishchenko, I. A. Boldyrev, N. S. Egorova, D. V. Vasina, V. A. Gushchin, A. S. Chernov, G. B. Telegin, V. A. Kazakov, K. S. Plokhikh, M. V. Konovalova, E. V. Svirshchevskaya, E. L. Vodovozova
Publikováno v:
Russian Journal of Bioorganic Chemistry. 48:S23-S37
Autor:
D S, Tretiakova, E L, Vodovozova
Publikováno v:
Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology. 16:1-20
The review considers liposomes as systems of substantial interest as adjuvant carriers in vaccinology due to their versatility and maximal biocompatibility. Research and development on the use of liposomes and lipid nanoparticles to create subunit va
Publikováno v:
Russian Chemical Reviews. 82:783-814
The results of experimental studies concerned with the development of nano-sized drug delivery systems for the antitumour drugs sarcolysine and melphalan are generalized. The structures and biological activities of nanocarriers in comparison with unm
Autor:
E. V. Moiseeva, N. R. Kuznetsova, E. V. Svirshchevskaya, N. V. Bovin, N. S. Sitnikov, A. S. Shavyrin, I. P. Beletskaya, S. Combes, A. Yu. Fedorov, E. L. Vodovozova
Publikováno v:
Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry. 5:276-283
Autor:
E. L. Vodovozova, Daria Zaytseva-Zotova, A. M. Tsoy, E. F. Edelweiss, Artur Bartkowiak, Elena Markvicheva, Jean-Louis Goergen
Publikováno v:
Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry. 4:243-250
To generate multicellular tumor spheroids (MTS) based on human breast adenocarcinoma MCF-7 cells and to study them as a novel in vitro model for anticancer drug screening, a technique for cell microencapsulation in biocompatible alginate-chitosan mic
Publikováno v:
Bioorganicheskaia khimiia. 40(1)
A fluorescent analog of the lipophilic prodrug of antitumor agent methotrexate has been synthesized. The conjugate consists of a residue of rac-1-[13-(Me4-BODIPY-8)tridecanoyl]-2-oleoylglycerol connected to methotrexate by ester bond via β-Ala-N-car
Autor:
N R, Kuznetsova, E V, Svirshchevskaya, N S, Sitnikov, L, Abodo, H, Sutorius, J, Zapke, J, Velder, P, Thomopoulou, H, Oschkinat, A, Prokop, H G, Schmalz, A Yu, Fedorov, E L, Vodovozova
Publikováno v:
Bioorganicheskaia khimiia. 39(5)
Colchicine site binders--blockers of tubulin polymerization--are potential antimitotic agents for anticancer therapy. To reduce their systemic toxicity and improve biodistribution, encapsulation in nanosized liposomes may be employed. Liposomes prese
Publikováno v:
Bioorganicheskaia khimiia. 33(4)
We have recently synthesized a lipid conjugate of the anticancer agent methotrexate (MTX-DG) and showed that the conjugate is quantitatively included in the lipid bilayer of liposomes prepared by a standard extrusion technique from an 8 : 1 : 1 (mol)
Publikováno v:
Bioorganicheskaia khimiia. 30(2)
A method for the synthesis of photoaffinity neoglycolipid probes with a highly efficient carbene-generating diazocyclopentadien-2-ylcarbonyl (Dcp) label, which can be radioiodinated under standard oxidation conditions, was developed. The probes are i