Zobrazeno 1 - 10
of 44
pro vyhledávání: '"E. L. Forker"'
Publikováno v:
Journal of Mathematical Biology. 31:273-289
We develop a simple mathematical model for bile formation and analyze some features of the model that suggest the design for future physiological experiments. The mathematical model results in a boundary value problem for a system of functional diffe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74ca39fac521682ceb3d9515d880a034
https://doi.org/10.1007/bf00166146
https://doi.org/10.1007/bf00166146
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 68:201-206
We compared the uptake of bound palmitate by rat hepatocytes to its uptake by polyethylene using β-lactoglobulin (BLG) as the binding protein. The experiments were designed to supply a direct measure of the protein-dependent change in the diffusive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba6fa107cf7cdfd158db88d76b402405
https://doi.org/10.1139/y90-031
https://doi.org/10.1139/y90-031
Publikováno v:
The American journal of physiology. 268(2 Pt 1)
Conventional interpretation of hepatic indicator dilution curves rests on the assumption, among others, that every hepatocyte operates with the same rate constants. When this assumption is false, owing to intralobular zonal variation in surface-to-vo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b616e28458e12ff5210240388456305
https://pubmed.ncbi.nlm.nih.gov/7864116
https://pubmed.ncbi.nlm.nih.gov/7864116
Publikováno v:
The American journal of physiology. 262(6 Pt 1)
The liver's apparently anomalous extraction of organic anions tightly bound to albumin continues to provoke controversy and confusion. Decisive experiments have proved difficult to design, and mathematical models have usually been constructed to defe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19c079a89bfec63b53d9aad86c4f79f7
https://pubmed.ncbi.nlm.nih.gov/1616042
https://pubmed.ncbi.nlm.nih.gov/1616042
Autor:
Z. S. Cai, E. L. Forker
Publikováno v:
The American journal of physiology. 262(1 Pt 1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a6a2b62eae61bbbd466221c25f107b7
https://pubmed.ncbi.nlm.nih.gov/1733266
https://pubmed.ncbi.nlm.nih.gov/1733266
Publikováno v:
Journal of Clinical Investigation. 77:964-970
The uptake of 14C-palmitate by rat liver cell monolayers is depressed by binding of the fatty acid to albumin. When the uptake flux is divided by the concentration of free palmitate in the bathing medium, however, the resulting clearance is approxima
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba5f3082c55f804e113d1a7683d3d600
https://doi.org/10.1172/jci112397
https://doi.org/10.1172/jci112397
Autor:
E L Forker
Publikováno v:
Annual Review of Physiology. 39:323-347
It should be evident from this review of recent investigations that we are still very far from a consistent description of bile formation, much less a satisfactory understanding. Nevertheless certain broad conclusions emerge. Four distinct kinds of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea9d4dfd4083db7a2b2fe31561b9eb6b
https://doi.org/10.1146/annurev.ph.39.030177.001543
https://doi.org/10.1146/annurev.ph.39.030177.001543
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 248:G702-G708
Gamma globulin and albumin are compared with respect to their effects on the hepatic transport of rose bengal and with respect to the rates and affinities with which they bind this dye. The apparent intrinsic clearance of rose bengal is greater in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdcc739a4a83522a424c05d33a687ae7
https://doi.org/10.1152/ajpgi.1985.248.6.g702
https://doi.org/10.1152/ajpgi.1985.248.6.g702
Autor:
B. A. Luxon, E. L. Forker
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 243:G532-G540
In the accompanying paper we explore the analysis of solute disappearance curves using conventional linear assumptions. In this study we extend the analysis to examine the possibility of using the same model to recover the average kinetic parameters
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f73eb59ba0afc3d780fe4766d6db27db
https://doi.org/10.1152/ajpgi.1982.243.6.g532
https://doi.org/10.1152/ajpgi.1982.243.6.g532