Case report: High-grade serous tubo-ovarian carcinoma with FGFR2::IQCG fusion and insights into targetability

Autor: Reiri Sono, Gottfried E. Konecny, Liying Zhang

Publikováno v: Frontiers in Oncology, Vol 14 (2024)

FGFR2 fusion is one of the classes of emerging therapeutic targets of precision oncology and is observed in many solid tumor types. Our understanding of oncogenic mechanisms and therapy effects of molecular targets tends to reflect those occurring in

Externí odkaz: https://doaj.org/article/0fc3e107d3ce4eaf992b9d850c453469

Strategies for prevention and management of ocular events occurring with mirvetuximab soravtansine

Autor: Andrew Hendershot, Mark Slabaugh, Kamran M. Riaz, Kathleen N. Moore, David M. O'Malley, Ursula Matulonis, Gottfried E. Konecny

Publikováno v: Gynecologic Oncology Reports, Vol 47, Iss , Pp 101155- (2023)

Mirvetuximab soravtansine (MIRV) is a first-in-class antibody-drug conjugate (ADC) targeting folate receptor alpha (FRα) and is indicated for the treatment of adult patients with FRα-positive, platinum-resistant epithelial ovarian, fallopian tube,

Externí odkaz: https://doaj.org/article/7bbfec9715e24a6da26bff5934edd4e9

Gene-Expression Profiling of Mucinous Ovarian Tumors and Comparison with Upper and Lower Gastrointestinal Tumors Identifies Markers Associated with Adverse Outcomes

Autor: Nicola S, Meagher, Kylie L, Gorringe, Matthew, Wakefield, Adelyn, Bolithon, Chi Nam Ignatius, Pang, Derek S, Chiu, Michael S, Anglesio, Kylie-Ann, Mallitt, Jennifer A, Doherty, Holly R, Harris, Joellen M, Schildkraut, Andrew, Berchuck, Kara L, Cushing-Haugen, Ksenia, Chezar, Angela, Chou, Adeline, Tan, Jennifer, Alsop, Ellen, Barlow, Matthias W, Beckmann, Jessica, Boros, David D L, Bowtell, Alison H, Brand, James D, Brenton, Ian, Campbell, Dane, Cheasley, Joshua, Cohen, Cezary, Cybulski, Esther, Elishaev, Ramona, Erber, Rhonda, Farrell, Anna, Fischer, Zhuxuan, Fu, Blake, Gilks, Anthony J, Gill, Charlie, Gourley, Marcel, Grube, Paul R, Harnett, Arndt, Hartmann, Anusha, Hettiaratchi, Claus K, Høgdall, Tomasz, Huzarski, Anna, Jakubowska, Mercedes, Jimenez-Linan, Catherine J, Kennedy, Byoung-Gie, Kim, Jae-Weon, Kim, Jae-Hoon, Kim, Kayla, Klett, Jennifer M, Koziak, Tiffany, Lai, Angela, Laslavic, Jenny, Lester, Yee, Leung, Na, Li, Winston, Liauw, Belle W X, Lim, Anna, Linder, Jan, Lubiński, Sakshi, Mahale, Constantina, Mateoiu, Simone, McInerny, Janusz, Menkiszak, Parham, Minoo, Suzana, Mittelstadt, David, Morris, Sandra, Orsulic, Sang-Yoon, Park, Celeste Leigh, Pearce, John V, Pearson, Malcolm C, Pike, Carmel M, Quinn, Ganendra Raj, Mohan, Jianyu, Rao, Marjorie J, Riggan, Matthias, Ruebner, Stuart, Salfinger, Clare L, Scott, Mitul, Shah, Helen, Steed, Colin J R, Stewart, Deepak, Subramanian, Soseul, Sung, Katrina, Tang, Paul, Timpson, Robyn L, Ward, Rebekka, Wiedenhoefer, Heather, Thorne, Paul A, Cohen, Philip, Crowe, Peter A, Fasching, Jacek, Gronwald, Nicholas J, Hawkins, Estrid, Høgdall, David G, Huntsman, Paul A, James, Beth Y, Karlan, Linda E, Kelemen, Stefan, Kommoss, Gottfried E, Konecny, Francesmary, Modugno, Sue K, Park, Annette, Staebler, Karin, Sundfeldt, Anna H, Wu, Aline, Talhouk, Paul D P, Pharoah, Lyndal, Anderson, Anna, DeFazio, Martin, Köbel, Michael L, Friedlander, Susan J, Ramus

Publikováno v: Meagher, N S, Gorringe, K L, Wakefield, M J, Bolithon, A, Pang, C N I, Chiu, D S, Anglesio, M S, Mallitt, K, Doherty, J A, Harris, H R, Schildkraut, J M, Berchuck, A, Cushing-haugen, K L, Chezar, K, Chou, A, Tan, A, Alsop, J, Barlow, E, Beckmann, M W, Boros, J, Bowtell, D D, Brand, A H, Brenton, J D, Campbell, I, Cheasley, D, Cohen, J, Cybulski, C, Elishaev, E, Erber, R, Farrell, R, Fischer, A, Fu, Z, Gilks, B, Gill, A J, Gourley, C, Grube, M, Harnett, P, Hartmann, A, Hettiaratchi, A, Høgdall, C K, Huzarski, T, Jakubowska, A, Jimenez-linan, M, Kennedy, C J, Kim, B, Kim, J, Kim, J, Klett, K, Koziak, J, Lai, T, Laslavic, A, Lester, J, Leung, Y, Li, N, Liauw, W, Lim, B W X, Linder, A, Lubinski, J, Mahale, S, Mateoiu, C, Mcinerny, S, Menkiszak, J, Minoo, P, Mittelstadt, S, Morris, D, Orsulic, S, Park, S Y, Pearce, C L, Pearson, J V, Pike, M C, Quinn, C M, Mohan, G R, Rao, J, Riggan, M J, Ruebner, M, Salfinger, S, Scott, C L, Shah, M, Steed, H, Stewart, C J R, Subramanian, D, Sung, S, Tang, K, Timpson, P, Ward, R L, Wiedenhoefer, R, Thorne, H, Cohen, P A, Crowe, P, Fasching, P A, Gronwald, J, Hawkins, N J, Høgdall, E, Huntsman, D G, James, P A, Karlan, B Y, Kelemen, L E, Kommoss, S, Konecny, G E, Modugno, F, Park, S K, Staebler, A, Sundfeldt, K, Wu, A H, Talhouk, A, Pharoah, P D P, Anderson, L, Defazio, A, Köbel, M, Friedlander, M L & Ramus, S J 2022, ' Gene expression profiling of mucinous ovarian tumors and comparison with upper and lower gastrointestinal tumors identifies markers associated with adverse outcomes. ', Clinical Cancer Research . https://doi.org/10.1158/1078-0432.CCR-22-1206, https://doi.org/10.1158/1078-0432.CCR-22-1206
AOCS Grp, Australian Pancreatic Genome Initi & kConFab Investigators 2022, ' Gene-Expression Profiling of Mucinous Ovarian Tumors and Comparison with Upper and Lower Gastrointestinal Tumors Identifies Markers Associated with Adverse Outcomes ', Clinical Cancer Research, vol. 28, no. 24, pp. 5383-5395 . https://doi.org/10.1158/1078-0432.CCR-22-1206

Purpose: Advanced-stage mucinous ovarian carcinoma (MOC) has poor chemotherapy response and prognosis and lacks biomarkers to aid stage I adjuvant treatment. Differentiating primary MOC from gastrointestinal (GI) metastases to the ovary is also chall

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68e7e60454f3d65c0cafb4f51f254763
https://doi.org/10.1158/1078-0432.ccr-22-1206

Comprehensive Cross-Population Analysis of High-Grade Serous Ovarian Cancer Supports No More Than Three Subtypes

Autor: Gregory P. Way, James Rudd, Chen Wang, Habib Hamidi, Brooke L. Fridley, Gottfried E. Konecny, Ellen L. Goode, Casey S. Greene, Jennifer A. Doherty

Publikováno v: G3: Genes, Genomes, Genetics, Vol 6, Iss 12, Pp 4097-4103 (2016)

Four gene expression subtypes of high-grade serous ovarian cancer (HGSC) have been previously described. In these early studies, a fraction of samples that did not fit well into the four subtype classifications were excluded. Therefore, we sought to

Externí odkaz: https://doaj.org/article/bed34b7f747a45e88b9a2b5baf3500de

Table S1 from BRCA Reversion Mutations in Circulating Tumor DNA Predict Primary and Acquired Resistance to the PARP Inhibitor Rucaparib in High-Grade Ovarian Carcinoma

Autor: Elizabeth M. Swisher, Iain A. McNeish, Thomas C. Harding, James D. Brenton, Heidi Giordano, James X. Sun, Robert L. Coleman, Gottfried E. Konecny, Clare L. Scott, Scott H. Kaufmann, Setsuko K. Chambers, David M. O'Malley, Lara Maloney, Jeffrey D. Isaacson, Elaina Mann, Lan-Thanh Vo, Carmen Say, Marc R. Radke, Elena Helman, Anna V. Tinker, Isabelle Ray-Coquard, Ana Oaknin, Amit M. Oza, Maria I. Harrell, Kevin K. Lin

Table S1 is an Excel sheet that provides a detailed listing of primary BRCA and TP53 mutations as well as BRCA reversion mutations detected in pretreatment and postprogression circulating cell-free DNA and tumor biopsy samples

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f0f0f04c6ffd5876ef9cd4816ed5860
https://doi.org/10.1158/2159-8290.22532690