Crystal structure of 4,4′-bis[3-(piperidin-1-yl)prop-1-yn-1-yl]-1,1′-biphenyl

Autor: Anqi Walbaum, E. Kim Fifer, Sean Parkin, Peter A. Crooks

Publikováno v: Acta Crystallographica Section E: Crystallographic Communications, Vol 73, Iss 6, Pp 864-866 (2017)

The title compound, C28H32N2, (I), is one of a second generation of compounds designed and synthesized based on a very potent and selective α9α10 nicotinic acetylcholine receptor antagonist ZZ161C {1,1′-[[1,1′-biphenyl]-4,4′-diylbis(prop-2-yn

Externí odkaz: https://doaj.org/article/af01711f6752425e8e4161d02380aece

Comparison of the crystal structures of 4,4′-bis[3-(4-methylpiperidin-1-yl)prop-1-yn-1-yl]-1,1′-biphenyl and 4,4′-bis[3-(2,2,6,6-tetramethylpiperidin-1-yl)prop-1-yn-1-yl]-1,1′-biphenyl

Autor: Anqi Wan, Narsimha Reddy Penthala, E. Kim Fifer, Sean Parkin, Peter A. Crooks

Publikováno v: Acta Crystallographica Section E: Crystallographic Communications, Vol 71, Iss 10, Pp 1132-1135 (2015)

As part of a comprehensive program to discover α9α10 nicotinic acetylcholine receptor antagonists, the title compounds C30H36N2, (I), and C36H48N2, (II), were synthesized by coupling 4,4′-bis(3-bromoprop-1-yn-1-yl)-1,1′-biphenyl with 4-methylpi

Externí odkaz: https://doaj.org/article/62abdeb5c0b54bfda480afd0c6ceb3a5

Crystal structure of 4,4'-bis-[3-(piperidin-1-yl)prop-1-yn-1-yl]-1,1'-biphen-yl

Autor: E. Kim Fifer, Peter A. Crooks, Anqi W. Walbaum, Sean Parkin

Publikováno v: Acta Crystallographica Section E: Crystallographic Communications
Acta Crystallographica Section E: Crystallographic Communications, Vol 73, Iss 6, Pp 864-866 (2017)

The synthesis and structure of the title piperidine derivative is reported. It is one of a second generation of compounds designed and synthesized based on a very potent and selective α9α10 nicotinic acetyl­choline receptor antagonist ZZ161C, whic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::436658994bda5e9a7353ce0242e6beaf
https://pubmed.ncbi.nlm.nih.gov/28638646

Drug–Organic Electrolyte Complexes as Controlled Release Systems

Autor: Rajesh Vadlapatla, Kenneth S. Alexander, Cherng-ju Kim, E. Kim Fifer

Publikováno v: Drug Development and Industrial Pharmacy. 35:1-11

A water-insoluble complex between diltiazem HCl and Na deoxycholate was prepared to achieve sustained release dosage forms. Physicochemical characterization of the drug complex was carried out with differential scanning calorimetry, (1)H-nuclear magn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b448fe030978a3a8d66651f2d723c93
https://doi.org/10.1080/03639040701842469

Protein kinase B/Akt modulates nephrotoxicant-induced necrosis in renal cells

Autor: E. Kim Fifer, Grazyna Nowak, Zabeena P. Shaik

Publikováno v: American Journal of Physiology-Renal Physiology. 292:F292-F303

Protein kinase B (Akt) activation is well known for its protective effects against apoptosis. However, the role of Akt in regulation of necrosis is unknown. This study was designed to test whether Akt activation protects against nephrotoxicant-induce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::767cdc5bf425862652f00013bdef9c4d
https://doi.org/10.1152/ajprenal.00082.2006