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Application of Caenorhabditis elegans (nematode) and Danio rerio embryo (zebrafish) as model systems to screen for developmental and reproductive toxicity of piperazine compounds

Autor: Raymond Pieters, Herman P. Spaink, E. Kerkhof, Elena Santidrian Yebra-Pimentel, Marjolein Wildwater, Peter Racz, Chantal Smulders, Graham Whale, Ron P. Dirks, Martijn Rooseboom

Publikováno v: Toxicology In Vitro, 44, 11-16. Elsevier
Toxicology In Vitro, 44, 11-16
Toxicology In Vitro

From the article: "To enable selection of novel chemicals for new processes, there is a recognized need for alternative toxicity screening assays to assess potential risks to man and the environment. For human health hazard assessment these screening

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe9ef066c3afd24d0ce34b1bd60805a8
https://hdl.handle.net/1887/55260

Combinatorial model organism strategy to predict developmental and reproductive toxicology (DART)

Autor: S. Maxwell, M. Wildwater, R.P. Dirks, Raymond Pieters, C. Smulders, E. Yebra-Pimentel, Herman P. Spaink, Peter Racz, R. Ruijtenbeek, Martijn Rooseboom, J. Louter–van de Haar, E. Kerkhof, C. Pears, R. Currie, G. Whale, Alison Woollard, D. Pijnenburg, E. Warren

Publikováno v: Toxicology Letters. 280:S94

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::be89a2117c2daa7a063d4ccdac52cac9
https://doi.org/10.1016/j.toxlet.2017.07.258

Paediatric community-acquired septic shock: results from the REPEM network study

Autor: J De Dooy, N Boelsma, J Willems, J Naud, E Kerkhof, M Mor, P. Van de Voorde, Dominique Biarent, C R Pinto, Alain Dupont, L. Da Dalt, Javier Benito, Marc Sabbe, Beth L. Emerson, H Waisman, Thierry Detaille, Ian Maconochie, Borja Gomez, N Qureshi, Said Hachimi-Idrissi, N Mullen, R Van Lancker, I Iglowstein, Henriëtte A. Moll, Dincer Yildizdas, David Walker

Publikováno v: European Journal of Pediatrics
European Journal of Pediatrics, Vol. 172, no.5, p. 667-674 (2013)
European journal of pediatrics
European journal of pediatrics, 172 (5

Introduction and purpose of the study With this study we aimed to describe a "true world" picture of severe pae-diatric 'community-acquired' septic shock and establish the feasibility of a future prospective trial on early goal-directed therapy in ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25f24613f4cdb162ca93c801ffca0036
http://hdl.handle.net/10044/1/63388

PO-0263 Safety Netting In Paediatric Emergency Care: A Systematic Review And Protocol Development

Autor: Henriette A. Moll, D Geurts, M Wiggers, Rianne Oostenbrink, E Kerkhof

Publikováno v: Archives of Disease in Childhood. 99:A331.2-A331

Background Safety netting strategies after emergency department (ED) discharge are mostly not standardised. Aim To develop a safety netting protocol for children at risk for serious infections (SI) discharged from the ED. Methods Patients: Children w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c102d5c2e401f5a7b8e56531d1c62c16
https://doi.org/10.1136/archdischild-2014-307384.917