Zobrazeno 1 - 10 of 39 pro vyhledávání: '"E. Kephart"'
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Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (R)-5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)-one (PF-06821497)
Autor: Pei-Pei, Kung, Patrick, Bingham, Alexei, Brooun, Michael, Collins, Ya-Li, Deng, Dac, Dinh, Connie, Fan, Ketan S, Gajiwala, Rita, Grantner, Hovhannes J, Gukasyan, Wenyue, Hu, Buwen, Huang, Robert, Kania, Susan E, Kephart, Cody, Krivacic, Robert A, Kumpf, Penney, Khamphavong, Manfred, Kraus, Wei, Liu, Karen A, Maegley, Lisa, Nguyen, Shijian, Ren, Dan, Richter, Robert A, Rollins, Neal, Sach, Shikhar, Sharma, John, Sherrill, Jillian, Spangler, Albert E, Stewart, Scott, Sutton, Sean, Uryu, Dominique, Verhelle, Hui, Wang, Shuiwang, Wang, Martin, Wythes, Shuibo, Xin, Shinji, Yamazaki, Huichun, Zhu, JinJiang, Zhu, Luke, Zehnder, Martin, Edwards
Publikováno v: Journal of medicinal chemistry. 61(3)
A new series of lactam-derived EZH2 inhibitors was designed via ligand-based and physicochemical-property-based strategies to address metabolic stability and thermodynamic solubility issues associated with previous lead compound 1. The new inhibitors
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::47b5a14cd255ea7adedb733daa3e1969
https://pubmed.ncbi.nlm.nih.gov/29211475
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6
Integrative Analysis of the Caenorhabditis elegans Genome by the modENCODE Project
Autor: L. Dick, Mark S. Guyer, D. Mecenas, William C. Spencer, Ming Sin Cheung, Sebastian D. Mackowiak, Tao Liu, A. Vielle, Abby F. Dernburg, Mitzi Morris, Bradley I. Arshinoff, Sheldon J. McKay, Amber Leahey, Thea A. Egelhofer, Lukas Habegger, Michael Snyder, Teruaki Takasaki, Roger P. Alexander, Stuart K. Kim, Ashish Agarwal, Ting Han, A. Leo Iniguez, Eric L. Van Nostrand, Gos Micklem, S. Taing, Ekta Khurana, Joel Rozowsky, Beijing Wu, Steven Henikoff, Adrian Carr, Philip Green, Angie S. Hinrichs, A. Muroyama, Jason D. Lieb, Paul Lloyd, Yaniv Lubling, P. Scheid, Kevin Y. Yip, Stefan R. Henz, Chao Cheng, Jiang Du, Mei Zhong, P. Alves, Elicia Preston, Zhi John Lu, Vishal Khivansara, Robert H. Waterston, J. Janette, C. Slightam, Frank J. Slack, David M. Miller, Eo Stinson, Nikolaus Rajewsky, Eran Segal, Jing Leng, Tony Hyman, R. Robilotto, C. Shou, Gunnar Rätsch, Eric C. Lai, Mihail Sarov, X. Shirley Liu, Isabel J. Latorre, A. Chateigner, Francois Gullier, Raymond K. Auerbach, W. James Kent, Sergio Contrino, Jeremy Brouillet, Lincoln Stein, T. Phippen, Andrea Sboner, Marco Mangone, Georg Zeller, Hoang Pham, Mark Gerstein, Michael J. MacCoss, Siew Loon Ooi, Cathleen M. Brdlik, D. Vafeados, Nicole L. Washington, Andreas Rechtsteiner, Peter J. Good, Susan Strome, Galt P. Barber, Kristin C. Gunsalus, John I. Murray, Valerie Reinke, Luke Dannenberg, Masaomi Kato, M. Jensen, X. Feng, John Kim, Kahn Rhrissorrakrai, H. Holster, Kohta Ikegami, Christina M. Whittle, M. Gutwein, Rachel Lyne, Wei Niu, Richard J.H. Smith, LaDeana W. Hillier, P. Kolasinska-Zwierz, Heidi Rosenbaum, Andréa C. Dosé, Xingliang Zhou, Marc D. Perry, Rajkumar Sasidharan, Rebecca F. Lowdon, Arshad Desai, Z. Zha, J. Brennan, Guilin Wang, P. Ruzanov, Brent Ewing, Gennifer E. Merrihew, Kim Rutherford, Reto Gassmann, Elise A. Feingold, Fabio Piano, Julie Ahringer, E. Kephart, Lucas Lochovsky, Sevinc Ercan, Suzanna E. Lewis, Ksenia Voronina, Koon-Kiu Yan, Jorja G. Henikoff, Hyunjin Shin, Hiram Clawson, Ghia Euskirchen
Publikováno v: Science. 330:1775-1787
From Genome to Regulatory Networks For biologists, having a genome in hand is only the beginning—much more investigation is still needed to characterize how the genome is used to help to produce a functional organism (see the Perspective by Blaxter
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::af1c9379c54f3982c93a77444265918c
https://doi.org/10.1126/science.1196914
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7
Cloud-based uniform ChIP-Seq processing tools for modENCODE and ENCODE
Autor: Quang M. Trinh, Lincoln Stein, Ziru Zhou, Sergio Contrino, Fei-Yang Arthur Jen, Marc D. Perry, P. Ruzanov, Kar Ming Chu, E. Kephart
Publikováno v: BMC Genomics
Background Funded by the National Institutes of Health (NIH), the aim of the Mod el Organism ENC yclopedia o f D NA E lements (modENCODE) project is to provide the biological research community with a comprehensive encyclopedia of functional genomic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5330ddf463bacc72ba452983f95a4099
https://doi.org/10.1186/1471-2164-14-494
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8
modMine: flexible access to modENCODE data
Autor: Richard N. Smith, Paul Lloyd, Rachel Lyne, Lincoln Stein, Sergio Contrino, Alexis Kalderimis, Daniela Butano, E. O. Stinson, Nicole L. Washington, Suzanna E. Lewis, Julie Sullivan, Adrian Carr, Z. Zha, E. Kephart, P. Ruzanov, Gos Micklem, Marc D. Perry, Kim M. Rutherford, Fengyuan Hu, Seth Carbon
Publikováno v: Nucleic Acids Research
In an effort to comprehensively characterize the functional elements within the genomes of the important model organisms Drosophila melanogaster and Caenorhabditis elegans, the NHGRI model organism Encyclopaedia of DNA Elements (modENCODE) consortium
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::220bc3d2a855034d691bd567328a602b
https://pubmed.ncbi.nlm.nih.gov/22080565
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9
The modENCODE Data Coordination Center: lessons in harvesting comprehensive experimental details
Autor: Rachel Lyne, Lincoln Stein, Nicole L. Washington, P. Ruzanov, Suzanna E. Lewis, Richard N. Smith, Z. Zha, E. Kephart, Marc D. Perry, E. O. Stinson, Adrian Carr, Paul Lloyd, Gos Micklem, Sergio Contrino, Sheldon J. McKay
Publikováno v: Database: The Journal of Biological Databases and Curation
The model organism Encyclopedia of DNA Elements (modENCODE) project is a National Human Genome Research Institute (NHGRI) initiative designed to characterize the genomes of Drosophila melanogaster and Caenorhabditis elegans. A Data Coordination Cente
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8363bb10ae4621b94786c8ba775aa3bb
https://doi.org/10.1093/database/bar023
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