Zobrazeno 1 - 10 of 229 pro vyhledávání: '"E. Kassab"'
1
Akademický článek
Remarks on the evolution and performance of the different austenite morphologies at the simulated HAZs of a 2205 duplex stainless steel
Autor: E.V. Morales, J.A. Pozo, L. Olaya, E. Kassab, J.A.C. Ponciano, K. Ghavami, I.S. Bott
Publikováno v: Journal of Materials Research and Technology, Vol 8, Iss 5, Pp 3936-3949 (2019)
Some features of the austenite micro structural evolution have been reviewed at the simulated HAZs (Heat Affected Zones) in a duplex stainless steel. The evolution of the different morphological forms of austenite was quantified in the microstructure
Externí odkaz: https://doaj.org/article/908a744eadff494cb79ee844abc2db4a
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2
Akademický článek
New 1,2,4-oxadiazole derivatives as potential multifunctional agents for the treatment of Alzheimer’s disease: design, synthesis, and biological evaluation
Autor: Mohammed Salah Ayoup, Mariam Ghanem, Hamida Abdel-Hamid, Marwa M. Abu-Serie, Aliaa Masoud, Doaa A. Ghareeb, Mohammed B. Hawsawi, Amr Sonousi, Asmaa E. Kassab
Publikováno v: BMC Chemistry, Vol 18, Iss 1, Pp 1-15 (2024)
Abstract A series of new 1,2,4-oxadiazole-based derivatives were synthesized and evaluated for their anti-AD potential. The results revealed that eleven compounds (1b, 2a-c, 3b, 4a-c, and 5a-c) exhibited excellent inhibitory potential against AChE, w
Externí odkaz: https://doaj.org/article/dc68b8e4e3bd464b9dddc323540f7db5
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3
Akademický článek
Design, synthesis, and biological evaluation of novel ciprofloxacin derivatives as potential anticancer agents targeting topoisomerase II enzyme
Autor: Hadeer K. Swedan, Asmaa E. Kassab, Ehab M. Gedawy, Salwa E. Elmeligie
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1, Pp 118-137 (2023)
A series of novel ciprofloxacin (CP) derivatives substituted at the N-4 position with biologically active moieties were designed and synthesised. 14 compounds were 1.02- to 8.66-fold more potent than doxorubicin against T-24 cancer cells. Ten compoun
Externí odkaz: https://doaj.org/article/002aa18319db48498f5640ab92ca8844
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4
Akademický článek
Rational Design and Synthesis of New Selective COX-2 Inhibitors with In Vivo PGE2-Lowering Activity by Tethering Benzenesulfonamide and 1,2,3-Triazole Pharmacophores to Some NSAIDs
Autor: Nada H. El-Dershaby, Soad A. El-Hawash, Shaymaa E. Kassab, Hoda G. Daabees, Ahmed E. Abdel Moneim, Mostafa M. M. El-Miligy
Publikováno v: Pharmaceuticals, Vol 15, Iss 10, p 1165 (2022)
New selective COX-2 inhibitors were designed and synthesized by tethering 1,2,3-triazole and benzenesulfonamide pharmacophores to some NSAIDs. Compounds 6b and 6j showed higher in vitro COX-2 selectivity and inhibitory activity (IC50 = 0.04 µM and S
Externí odkaz: https://doaj.org/article/16314089b06f4edc993ae0c921a54ade
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5
Recent Advances in the Synthesis of Thiazole Ring: Mini Review
Autor: Asmaa E. Kassab, Inas G. Shahin, Khaled O. Mohamed, Azza T. Taher, Abdelrahman S. Mayhoub
Publikováno v: Mini-Reviews in Organic Chemistry. 20:270-284
Abstract: The thiazole scaffold is an essential structural foundation in a plethora of pharmaceutical products having an extensive array of biological activities. Consequently, its synthesis has been extensively discussed in the literature. In this m
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f98c545a9c2d3630dcfa1b17c2ac58a7
https://doi.org/10.2174/1570193x19666220413104255
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6
Design and Synthesis of Novel Celecoxib Analogues with Potential Cytotoxic and Pro-apoptotic Activity against Breast Cancer Cell Line MCF-7
Autor: Eman F, Abdelhaleem, Asmaa E, Kassab, Hala B, El-Nassan, Omneya M, Khalil
Publikováno v: Medicinal Chemistry. 18:903-914
Background: Breast cancer is currently the leading cause of worldwide cancer incidence exceeding lung cancer. In addition, breast cancer accounts for 1 in 4 cancer cases and 1 in 6 cancer deaths among women. Cytotoxic chemotherapy is still the main t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f7fcd9452a7d4352b396e874a9d391e
https://doi.org/10.2174/1573406418666220309123648
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7
Design, synthesis, and biological evaluation of thienopyrimidine and thienotriazine derivatives as multitarget anti‐Alzheimer agents
Autor: Kholoud I. Eissa, Mona M. Kamel, Lamia W. Mohamed, Mai A. Galal, Asmaa E. Kassab
Publikováno v: Drug Development Research. 83:1394-1407
A series of tetrahydrobenzothienopyrimidines and tetrahydrobenzothienotriazines incorporating a pharmacophore from donepezil molecule were designed and synthesized. The 12 newly synthesized compounds were screened for their inhibition activity agains
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f105c4197d928ef66f7456e53d1a4103
https://doi.org/10.1002/ddr.21968
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10
Structural Basis of Selective Human Indoleamine‐2,3‐dioxygenase 1 (hIDO1) Inhibition
Autor: Shaymaa E. Kassab, Samar Mowafy
Publikováno v: ChemMedChem. 16:3149-3164
hIDO1 is a heme-dioxygenase overexpressed in the tumor microenvironment and is implicated in the survival of cancer cells. Metabolism of tryptophan to N-formyl-kynurenine by hIDO1 leads to immune suppression to result in cancer cell immune escape. In
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77d5c659dbb977a5c7a48a0cf7b58857
https://doi.org/10.1002/cmdc.202100253
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