Zobrazeno 1 - 10
of 146
pro vyhledávání: '"E. Karge"'
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 30:203-218
Fibrates lead to a reduction of serum triglycerides and cholesterol in hyperlipidemic patients. Their therapeutic use, however, can be associated with adverse effects like gastrointestinal disorders, myalgia, myositis and hepatotoxicity. Large doses
Publikováno v:
Experimental and Toxicologic Pathology. 54:441-448
Summary In the first part of the study possible additional antioxidative effects of various N-methyl-D-aspartate (NMDA)-receptor antagonists, some of which are used in the treatment of Parkinson's or Alzheimer's disease or as narcotic (dizocilpine, k
Publikováno v:
Experimental and Toxicologic Pathology. 54:467-473
Species differences in the interactions of cyclosporine A (CSA) and tacrolimus (TAC) with the cytochrome P450 (CYP) system in male rat and human liver were investigated in vitro by assessing effects on a series of model reactions for different CYP is
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 26:31-35
In vitro melatonin binds to human and rat liver microsomal cytochrome P-450 (P450) according to a type II substrate. The affinity is similar to that of aniline with a general left-shift. Melatonin interferes with model monooxygenase reactions indicat
Publikováno v:
Kidney International. 59:S14-S18
Serum concentrations of asymmetric (ADMA) and symmetric (SDMA) dimethylarginine in renal failure patients. Background Nitric oxide (NO) synthesis is inhibited by the ADMA that accumulates in the plasma of patients with renal failure; however, the con
Publikováno v:
Urological Research. 28:383-390
This paper is the third of a long-term planned series of papers dealing with ex vivo investigations of drug transport in human kidney. The aims of this study are (a) to investigate whether or not human renal cell carcinoma (RCC) can actively accumula
Publikováno v:
Europe PubMed Central
Metabolic pathways of oestrogens are the formation of catechol oestrogens (CE; 2- and 4-hydroxy-oestrogens), redox cycling of CE and free radical generation, mediated through cytochrome P450 (P450) oxidase/reductase activity. We checked the oestrogen
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 24:63-68
Both chlormezanone enantiomers, for the first time obtained by enantiospecific HPLC with a 100% yield, bind to oxidized cytochrome P-450 in rat liver microsomes with a binding curve according to type I, similar to hexobarbital but less pronounced. Th
Publikováno v:
Journal of Bioluminescence and Chemiluminescence. 13:355-363
Evidence is provided that the amplifiers luminol and lucigenin react with different reactive oxygen species (ROS), depending on the ROS-generating system used. H2O2 is used to produce calibration curves for luminol- and lucigenin-amplified chemilumin
Autor:
E. Karge, H. Oelschläger, S. Löbel, W. Kühnel, Thomas Deufel, D. Rothley, M. Klinger, Amelie Lupp, M. Danz, Martin Müller, Werner Linss, Wolfgang Klinger
Publikováno v:
Europe PubMed Central
Summary Ciprofibrates (racemate and both enantiomers, Raccip, R- and Scip) were administered orally in doses of 1 and 10 mg/kg once daily over 28 days to male inbred Fischer 344 rats, age 90–110 days at the beginning of the experiment. Body mass ga