Výsledky vyhledávání - "E. K.-H. Han"

Aminopyrimidinone Cdc7 Kinase Inhibitors

Autor: Niru B. Soni, Eric F. Johnson, Joel D. Leverson, Thomas D. Penning, Keith W. Woods, Yan Shi, Loren M. Lasko, Julie M. Miyashiro, Alan S. Florjancic, E. K.-H. Han, Chunqiu Lai, Alexander R. Shoemaker, Yunsong Tong

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 22:1940-1943

We have investigated the SAR of a series of pyrimidinone-containing Cdc7 kinase inhibitors. A wide range of amine substitutions give potent compounds with activities (K(i)) less than 1nM. Kinase selectivity is reasonable and cytotoxicity corresponds

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdf3f74c76d9ced20f6761e60f152a42
https://doi.org/10.1016/j.bmcl.2012.01.041

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Optimal Classes of Chemotherapeutic Agents Sensitized by Specific Small-Molecule Inhibitors of Akt In Vitro and In Vivo

Autor: Thomas McGonigal, Keith W. Woods, Alexander R. Shoemaker, E. K.-H. Han, Yan Luo, Vered Klinghofer, Vincent L. Giranda, Anatol Oleksijew, Loren M. Lasko, Ran Guan, Xuesong Liu, John P. Fisher, Qun Li, Yan Shi, Saul H. Rosenberg

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 7, Iss 11, Pp 992-1000 (2005)

Akt is a serine/threonine kinase that transduces survival signals from survival/growth factors. Deregulation and signal imbalance in cancer cells make them prone to apoptosis. Upregulation or activation of Akt to aid the survival of cancer cells is a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40165fee0498ce5ee21699559e84bce2
http://www.sciencedirect.com/science/article/pii/S147655860580034X

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Modulation of paclitaxel resistance by annexin IV in human cancer cell lines

Autor: E. K.-H. Han, S. P. Cherian, S. K. Tahir, N. Collins, S.-C. Ng

Publikováno v: British Journal of Cancer

A recurring problem with cancer therapies is the development of drug resistance. While investigating the protein profile of cells resistant to a novel antimitotic compound (A204197), we discovered an increase in annexin IV expression. When we examine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df4a9f13b1ad7d692df6d5c4fbf797b9
https://doi.org/10.1054/bjoc.2000.1311

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The α isoform of protein kinase C mediates phorbol ester-induced growth inhibition and p21cip1 induction in HC11 mammary epithelial cells

Autor: Eric D. Slosberg, Michael G. Klein, E. K.-H. Han, I. Schieren, I. B. Weinstein, Yao Yao

Publikováno v: Oncogene. 18:6658-6666

To clarify the roles of specific isoforms of PKC in regulating growth and cell cycle progression of the HC11 mammary epithelial cell line, we investigated the effects of activating endogenous PKC isoforms with the phorbol ester tumor promoter TPA, an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aa2b31cfd123956dc64685403c0ca38
https://doi.org/10.1038/sj.onc.1203083

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Sulindac derivatives inhibit growth and induce apoptosis in human prostate cancer cell lines

Autor: Paul H. Gross, I. Bernard Weinstein, Gerhard Sperl, Han Li, Gary A. Piazza, E. K.-H. Han, Thomas Delohery, Rifat Pamukcu, Klaus Brendel, Hirofumi Yamamoto, Tyler S. Finn, Ralph Buttyan, Jin T. E. Lim

Publikováno v: Biochemical Pharmacology. 58:1097-1107

We examined the activity of two metabolites of sulindac (a nonsteroidal anti-inflammatory drug), sulindac sulfide and sulindac sulfone (exisulind, Prevatec), and a novel highly potent analog of exisulind (CP248) on a series of human prostate epitheli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0094e1f860ac8f1aa2efe52d5d295d4
https://doi.org/10.1016/s0006-2952(99)00200-2

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[Untitled]

Autor: I. B. Weinstein, E. K.-H. Han, Martin Begemann, N Arber, S.-C. Ng

Publikováno v: APOPTOSIS. 4:213-219

It is now apparent that apoptosis is closely linked to the control of cell cycle progression. During the G1 to S progression, cyclin D1, p53, and the cyclin dependent kinase inhibitors p21WAF1 and p27kip1 can play roles in induction of apoptosis. Dur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7ff3d3d31e510df415649132f3230408
https://doi.org/10.1023/a:1009618824145

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Cyclin D1 expression in human prostate carcinoma cell lines and primary tumors

Autor: I. B. Weinstein, N. Arber, E. K.-H. Han, Wang Qiu Xing, J. T. E. Lim, Mark A. Rubin

Publikováno v: The Prostate. 35:95-101

Background The cyclin D1 gene is amplified and/or overexpressed in several types of human cancer, including cancers of the breast, esophagus, head, and neck. However, the role of cyclin D1 in prostate cancer has not been previously studied in detail.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a0d557872d2e918bf98e32158e35fc7c
https://doi.org/10.1002/(sici)1097-0045(19980501)35:2<95::aid-pros2>3.0.co

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A K-ras oncogene increases resistance to sulindac-induced apoptosis in rat enterocytes

Autor: Peter R. Holt, Christopher M. Weghorst, Thomas Delohery, N Arber, Dennis J. Ahnen, G. A. Piazza, N.-H. Kim, J. C. Reed, E. K.-H. Han, R. Pamukcu, Martin Begemann, Alessandro Sgambato, I. B. Weinstein

Publikováno v: Gastroenterology. 113:1892-1900

BACKGROUND & AIMS: Mutations of c-K-ras occur commonly in colonic neoplasms. The aim of this study was to determine how c-K-ras mutations alter the responses to the chemopreventive agent sulindac. METHODS: The parental rat intestinal cell line IEC-18

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1825bb77694184b7526b4d4498e2ff6c
https://doi.org/10.1016/s0016-5085(97)70008-8

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Radon-induced neoplastic transformation of human bronchial epithelial cells

Autor: Thomas Sutter, Tom K. Hei, E. K.-H. Han, Chang Q. Piao, James C. Willey

Publikováno v: Radiation Oncology Investigations. 3:398-403

Epidemiological studies have shown that inhalation of radon is associated with an increased risk for lung cancer among underground miners. The cellular and molecular mechanisms for radon-induced carcinogenesis are not clear. By using a human papillom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::acb8d7743345e9d4fdbee4d75446b439
https://doi.org/10.1002/roi.2970030628

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