Zobrazeno 1 - 10
of 117
pro vyhledávání: '"E. K. Rowinsky"'
Autor:
E. K. Rowinsky
Publikováno v:
The Oncologist. 8:5-17
Autor:
E. K. Rowinsky
Publikováno v:
The Oncologist. 8:1-4
Autor:
E. Campbell, J. G. Kuhn, Anthony W. Tolcher, J. Rizzo, Geoffrey R. Weiss, Elzbieta Izbicka, E. K. Rowinsky, C. Aylesworth, D. D. Von Hoff
Publikováno v:
Annals of Oncology. 11:333-338
Summary Background; Rhizoxin (NSC 332598) is a novel macrolide antitumor antibiotic that inhibits microtubule assembly and also depolymerizes preformed microtubules. In preclinical evaluations, rhizoxin demonstrated broad antitumor activity in vitro
Autor:
D. D. Von Hoff, Eric Raymond, E. K. Rowinsky, Axel-R. Hanauske, Gary M. Clark, Sandrine Faivre, Elzbieta Izbicka
Publikováno v:
Anti-Cancer Drugs. 8:379-385
Paclitaxel shows a broad clinical activity in ovarian, breast and non-small cell lung cancers. However, controversy remains about the respective effects of doses and schedules in paclitaxel cytotoxicity. This study was conducted to compare the cytoto
Autor:
Michael T. Crow, Edward G. Lakatta, E K Rowinsky, Rebecca R. Pauly, Jeffrey P. Froehlich, Robert E. Monticone, Masafumi Kuzuya, Linda Cheng, Steven J. Sollott, G M Jenkins
Publikováno v:
Journal of Clinical Investigation. 95:1869-1876
Despite significant improvements in the primary success rate of the medical and surgical treatments for atherosclerotic disease, including angioplasty, bypass grafting, and endarterectomy, secondary failure due to late restenosis continues to occur i
Autor:
Jennifer L. Spratlin, Roger B. Cohen, S. Gail Eckhardt, Laura Q.M. Chow, Matthew Eadens, Cindy L. O'Bryant, E. K. Rowinsky, Nancy L. Lewis, E. Gabriela Chiorean, Natalie J. Serkova, Lia Gore, Sami Diab, D. Ross Camidge, Stephen Leong, N. J. Meropol, Floyd Fox, Hagop Youssoufian
Publikováno v:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 28(5)
Purpose To evaluate the safety, maximum-tolerated dose (MTD), pharmacokinetics (PKs), pharmacodynamics, and preliminary anticancer activity of ramucirumab (IMC-1121B), a fully human immunoglobulin G1 monoclonal antibody targeting the vascular endothe
Publikováno v:
Blood. 75:1319-1323
Bryostatin 1, a macrocyclic lactone isolated from the marine bryozoan Bugula neritina, has demonstrated both antineoplastic activity against the murine P388 leukemia line in vivo and stimulatory activity against mouse and human hematopoietic progenit
Autor:
F A, Holmes, E K, Rowinsky
Publikováno v:
Seminars in oncology. 28(4 Suppl 12)
Paclitaxel and docetaxel each possess unique chemical and pharmacologic characteristics that account for significant differences in their potencies, toxicologic and pharmacokinetic profiles, and propensity for drug-drug interactions. Results from pha
Autor:
S D, Gore, L J, Weng, S, Zhai, W D, Figg, R C, Donehower, G J, Dover, M, Grever, C A, Griffin, L B, Grochow, E K, Rowinsky, Y, Zabalena, A L, Hawkins, K, Burks, C B, Miller
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 7(8)
Sodium phenylbutyrate (PB) is an aromatic fatty acid with cytostatic and differentiating activity against malignant myeloid cells (ID(50), 1-2 mM). Higher doses induce apoptosis. Patients with myelodysplasia (n = 11) and acute myeloid leukemia (n = 1
Autor:
G, Schwartz, T R, Johnson, A, Goetz, H, Burris, L, Smetzer, T, Lampkin, J, Sailstad, J A, Hohneker, D D, Von Hoff, E K, Rowinsky
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 7(7)
This study was performed to assess the feasibility of administering 1843U89, a potent, noncompetitive inhibitor of thymidylate synthase that does not require polyglutamation for activity, as a 2-min i.v. infusion daily for 5 days every 3 weeks, to de