Zobrazeno 1 - 10
of 19
pro vyhledávání: '"E. K. Lie"'
Autor:
T. Surawy-Stepney, A. E. Hogg, S. L. Cornford, B. J. Wallis, B. J. Davison, H. L. Selley, R. A. W. Slater, E. K. Lie, L. Jakob, A. Ridout, N. Gourmelen, B. I. D. Freer, S. F. Wilson, A. Shepherd
Publikováno v:
The Cryosphere, Vol 18, Pp 977-993 (2024)
We observe the evacuation of 11-year-old landfast sea ice in the Larsen B embayment on the East Antarctic Peninsula in January 2022, which was in part triggered by warm atmospheric conditions and strong offshore winds. This evacuation of sea ice was
Externí odkaz:
https://doaj.org/article/0d0f5b5cde034d2c8dea75a01098c062
Autor:
Stefanie Kickinger, Maria E. K. Lie, Akihiro Suemasa, Anas Al-Khawaja, Koichi Fujiwara, Mizuki Watanabe, Kristine S. Wilhelmsen, Christina B. Falk-Petersen, Bente Frølund, Satoshi Shuto, Gerhard F. Ecker, Petrine Wellendorph
Publikováno v:
Frontiers in Chemistry, Vol 9 (2021)
The betaine/GABA transporter 1 (BGT1) is a member of the GABA transporter (GAT) family with still elusive function, largely due to a lack of potent and selective tool compounds. Based on modeling, we here present the design, synthesis and pharmacolog
Externí odkaz:
https://doaj.org/article/eb62ced04b7242589c80acca580e939a
Autor:
Louise Piilgaard, Maria E. K. Lie, Petrine Wellendorph, Nane Griem-Krey, Christina Birkedahl Falk-Petersen, Birgitte Rahbek Kornum
Publikováno v:
European Journal of Neuroscience. 54:4445-4455
γ-Aminobutyric acid (GABA) acting through heteropentameric GABAA receptors plays a pivotal role in the sleep-promoting circuitry. Whereas the role of the different GABAA receptor α-subunits in sleep regulation and in mediating the effect of benzodi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c39e3f107fe8a8544b591e388fac4f3
https://doi.org/10.1111/ejn.15267
https://doi.org/10.1111/ejn.15267
Autor:
Keisuke Mitsui, Maria E. K. Lie, Naoki Saito, Koichi Fujiwara, Mizuki Watanabe, Petrine Wellendorph, Satoshi Shuto
Publikováno v:
Organic letters. 24(23)
Novel γ-aminobutyric acid (GABA) analogues
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab0ee664794c7d7ceec43bc29488fe0f
https://pubmed.ncbi.nlm.nih.gov/35674784
https://pubmed.ncbi.nlm.nih.gov/35674784
Autor:
Blanca I. Aldana, Lasse K. Bak, Emil Jakobsen, Maria E. K. Lie, Caroline M. Voss, Emil W. Westi, Lars H. Pinborg, Arne Schousboe, Jens V. Andersen, Helle S. Waagepetersen, Petrine Wellendorph
Publikováno v:
Glia. 68:2601-2612
Synaptic transmission is closely linked to brain energy and neurotransmitter metabolism. However, the extent of brain metabolism of the inhibitory neurotransmitter γ-aminobutyric acid (GABA), and the relative metabolic contributions of neurons and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::966d93a4ba80bbd3d00c6f74b363038a
https://doi.org/10.1002/glia.23872
https://doi.org/10.1002/glia.23872
Autor:
Arne Schousboe, Rasmus P. Clausen, Stefanie Kickinger, Jonas Skovgaard-Petersen, Maria E. K. Lie, Gerhard F. Ecker, Petrine Wellendorph, H. Steve White
Publikováno v:
Lie, M E K, Kickinger, S, Skovgaard-Petersen, J, Ecker, G F, Clausen, R P, Schousboe, A, White, H S & Wellendorph, P 2020, ' Pharmacological Characterization of a Betaine/GABA Transporter 1 (BGT1) Inhibitor Displaying an Unusual Biphasic Inhibition Profile and Anti-seizure Effects ', Neurochemical Research, vol. 45, pp. 1551–1565 . https://doi.org/10.1007/s11064-020-03017-y
Neurochemical Research
Neurochemical Research
Focal epileptic seizures can in some patients be managed by inhibiting γ-aminobutyric acid (GABA) uptake via the GABA transporter 1 (GAT1) using tiagabine (Gabitril®). Synergistic anti-seizure effects achieved by inhibition of both GAT1 and the bet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3be1e5b0f009359dee573c6df3162134
https://curis.ku.dk/portal/da/publications/pharmacological-characterization-of-a-betainegaba-transporter-1-bgt1-inhibitor-displaying-an-unusual-biphasic-inhibition-profile-and-antiseizure-effects(f58627b3-6c59-4d36-ad00-48d86bf6a034).html
https://curis.ku.dk/portal/da/publications/pharmacological-characterization-of-a-betainegaba-transporter-1-bgt1-inhibitor-displaying-an-unusual-biphasic-inhibition-profile-and-antiseizure-effects(f58627b3-6c59-4d36-ad00-48d86bf6a034).html
Autor:
Stefanie Kickinger, Maria Damgaard, Anas Al-Khawaja, Rebekka Löffler, Gerhard F. Ecker, Maria E. K. Lie, Bente Frølund, Petrine Wellendorph, Anne S. Haugaard, Francesco Bavo
Publikováno v:
Biophysical Journal. 118:130a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67c677d94d3244ada5e2856693b54ed7
https://doi.org/10.1016/j.bpj.2019.11.842
https://doi.org/10.1016/j.bpj.2019.11.842
Autor:
Maria E K, Lie, Anas, Al-Khawaja, Maria, Damgaard, Anne S, Haugaard, Arne, Schousboe, Andrew N, Clarkson, Petrine, Wellendorph
Publikováno v:
Advances in neurobiology. 16
Imbalances in GABA-mediated tonic inhibition are involved in several pathophysiological conditions. A classical way of controlling tonic inhibition is through pharmacological intervention with extrasynaptic GABA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::47a9d024c3dffa945e471323337a1c6f
https://pubmed.ncbi.nlm.nih.gov/28828609
https://pubmed.ncbi.nlm.nih.gov/28828609
Autor:
Maria, Damgaard, Anne Stæhr, Haugaard, Stefanie, Kickinger, Anas, Al-Khawaja, Maria E K, Lie, Gerhard F, Ecker, Rasmus Prætorius, Clausen, Bente, Frølund
Publikováno v:
Advances in neurobiology. 16
γ-Aminobutyric acid (GABA) neurotransmission is terminated by the GABA transporters (GATs) via uptake of GABA into neurons and surrounding glial cells. Four different transporters have been identified: GAT1, GAT2, GAT3, and the betaine/GABA transpor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a24459a1c71adde866615832c8e68064
https://pubmed.ncbi.nlm.nih.gov/28828618
https://pubmed.ncbi.nlm.nih.gov/28828618
Autor:
Anas Al-Khawaja, Maria E. K. Lie, Andrew N. Clarkson, Petrine Wellendorph, Maria Damgaard, Arne Schousboe, Anne S. Haugaard
Publikováno v:
Advances in Neurobiology ISBN: 9783319557670
Imbalances in GABA-mediated tonic inhibition are involved in several pathophysiological conditions. A classical way of controlling tonic inhibition is through pharmacological intervention with extrasynaptic GABAA receptors that sense ambient GABA and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb72cc7fd2e7addf54933b12220f7b47
https://doi.org/10.1007/978-3-319-55769-4_7
https://doi.org/10.1007/978-3-319-55769-4_7