Zobrazeno 1 - 10
of 30
pro vyhledávání: '"E. Josue Ruiz"'
Autor:
Christopher A. Waudby, Saul Alvarez-Teijeiro, E. Josue Ruiz, Simon Suppinger, Nikos Pinotsis, Paul R. Brown, Axel Behrens, John Christodoulou, Anastasia Mylona
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Phosphorylation at multiple sites is a major regulatory mechanism in cellular signalling. Here, the authors show that multisite phosphorylation of the c-JUN transcription factor by the JNK kinase exhibits intrinsic kinetics that allow a precise and t
Externí odkaz:
https://doaj.org/article/449495f650ce4cc3a30aa7a2b8fcd3ce
Autor:
E Josue Ruiz, Adan Pinto-Fernandez, Andrew P Turnbull, Linxiang Lan, Thomas M Charlton, Hannah C Scott, Andreas Damianou, George Vere, Eva M Riising, Clive Da Costa, Wojciech W Krajewski, David Guerin, Jeffrey D Kearns, Stephanos Ioannidis, Marie Katz, Crystal McKinnon, Jonathan O'Connell, Natalia Moncaut, Ian Rosewell, Emma Nye, Neil Jones, Claire Heride, Malte Gersch, Min Wu, Christopher J Dinsmore, Tim R Hammonds, Sunkyu Kim, David Komander, Sylvie Urbe, Michael J Clague, Benedikt M Kessler, Axel Behrens
Publikováno v:
eLife, Vol 10 (2021)
Lung squamous cell carcinoma (LSCC) is a considerable global health burden, with an incidence of over 600,000 cases per year. Treatment options are limited, and patient’s 5-year survival rate is less than 5%. The ubiquitin-specific protease 28 (USP
Externí odkaz:
https://doaj.org/article/eeea231092ca40e880a44f8ed5d20d8d
Autor:
Huafu Li, Chunming Wang, Linxiang Lan, Wenhui Wu, Ian Evans, E. Josue Ruiz, Leping Yan, Zhijun Zhou, Joaquim M. Oliveira, Rui L. Reis, Zhenran Hu, Wei Chen, Axel Behrens, Yulong He, Changhua Zhang
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Oxaliplatin (OXA) resistance in the treatment of different types of cancer is an important and complex problem. The culture of tumor organoids derived from gastric cancer can help us to provide a deeper understanding of the underlying mechanisms that
Externí odkaz:
https://doaj.org/article/1a708a1fd2ea485db52e0b41bef62450
Autor:
E. Josue Ruiz, Linxiang Lan, Markus Elmar Diefenbacher, Eva Madi Riising, Clive Da Costa, Atanu Chakraborty, Joerg D. Hoeck, Bradley Spencer-Dene, Gavin Kelly, Jean-Pierre David, Emma Nye, Julian Downward, Axel Behrens
Publikováno v:
JCI Insight, Vol 6, Iss 13 (2021)
The AP-1 transcription factor c-Jun is required for Ras-driven tumorigenesis in many tissues and is considered as a classical proto-oncogene. To determine the requirement for c-Jun in a mouse model of K-RasG12D–induced lung adenocarcinoma, we induc
Externí odkaz:
https://doaj.org/article/d1bdf75630574d7b9e1c28b13a237cf7
Autor:
Axel Behrens, Julian Downward, Yulong He, Yihang Pan, Ningning Li, Emma L. Nye, Gordon W. H. Stamp, Christopher Moore, E. Josue Ruiz, Hanna Foster
Tumor cells proliferate rapidly and thus are frequently subjected to replication stress and the risk of incomplete duplication of the genome. Fragile sites are replicated late, making them more vulnerable to damage when DNA replication fails to compl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16fbf07556299d27637987ebea2d457a
https://doi.org/10.1158/0008-5472.c.6511050
https://doi.org/10.1158/0008-5472.c.6511050
Autor:
Axel Behrens, Julian Downward, Yulong He, Yihang Pan, Ningning Li, Emma L. Nye, Gordon W. H. Stamp, Christopher Moore, E. Josue Ruiz, Hanna Foster
Supplementary figure S1. ATM is altered in LUAD and reduced expression correlates with poor survival. Supplementary figure S2. ATMIN and ATM immunohistochemical staining on LUAD and adjacent normal lung tissue. Supplementary figure S3. LUAD tumors de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::314f62f4ba17287b75343def153b7123
https://doi.org/10.1158/0008-5472.22421844.v1
https://doi.org/10.1158/0008-5472.22421844.v1
Autor:
Axel Behrens, Clive Da Costa, Min Wu, David Joseph Guerin, Emma Nye, Jonathan O'Connell, Adan Pinto-Fernandez, Eva M. Riising, Jeffrey D Kearns, Tim Hammonds, Andrew P. Turnbull, Crystal McKinnon, E. Josue Ruiz, Claire Heride, Christopher J. Dinsmore, Malte Gersch, Ian Rosewell, Thomas M. Charlton, Linxiang Lan, Neil P. Jones, Andreas Damianou, Hannah C. Scott, Benedikt M. Kessler, Sylvie Urbé, Michael J. Clague, Natalia Moncaut, Wojciech W. Krajewski, Stephanos Ioannidis, David Komander, Marie Katz, Sunkyu Kim, George Vere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::205d91672bd258cadd1c178b2544807d
https://doi.org/10.7554/elife.71596.sa2
https://doi.org/10.7554/elife.71596.sa2
Autor:
Malte Gersch, Thomas M. Charlton, Michael J. Clague, Linxiang Lan, Hannah C. Scott, Sylvie Urbé, George Vere, Min Wu, Sunkyu Kim, Stephanos Ioannidis, Claire Heride, Jeffrey D Kearns, Jonathan O'Connell, David Komander, Adan Pinto-Fernandez, E. Josue Ruiz, Emma Nye, Axel Behrens, Benedikt M. Kessler, Andrew P. Turnbull, Marie Katz, Natalia Moncaut, Andreas Damianou, Wojciech W. Krajewski, Neil P. Jones, Christopher J. Dinsmore, Ian Rosewell, Tim Hammonds, David Joseph Guerin, Eva M. Riising, Crystal McKinnon, Clive Da Costa
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
Lung squamous cell carcinoma (LSCC) is a considerable global health burden, with an incidence of over 600,000 cases per year. Treatment options are limited, and patient’s 5-year survival rate is less than 5%. The ubiquitin-specific protease 28 (USP
Autor:
Huafu Li, Chunming Wang, Linxiang Lan, Leping Yan, Wuguo Li, Ian Evans, E. Josue Ruiz, Qiao Su, Guangying Zhao, Wenhui Wu, Haiyong Zhang, Zhijun Zhou, Zhenran Hu, Wei Chen, Joaquim M. Oliveira, Axel Behrens, Rui L. Reis, Changhua Zhang
Publikováno v:
Cellular and molecular life sciences : CMLS. 79(3)
Oxaliplatin is the first-line regime for advanced gastric cancer treatment, while its resistance is a major problem that leads to the failure of clinical treatments. Tumor cell heterogeneity has been considered as one of the main causes for drug resi
Autor:
Axel Behrens, Atanu Chakraborty, Joerg D. Hoeck, Emma Nye, Clive Da Costa, Gavin Kelly, Markus E. Diefenbacher, Julian Downward, E. Josue Ruiz, Linxiang Lan, Bradley Spencer-Dene, Jean-Pierre David, Eva M. Riising
Publikováno v:
JCI Insight
The AP-1 transcription factor c-Jun is required for Ras-driven tumorigenesis in many tissues and is considered as a classical proto-oncogene. To determine the requirement for c-Jun in a mouse model of K-RasG12D-induced lung adenocarcinoma, we inducib