Zobrazeno 1 - 10
of 14
pro vyhledávání: '"E. J. Jarvi"'
Publikováno v:
Bulletin of Environmental Contamination and Toxicology. 73:898-902
Publikováno v:
Carcinogenesis. 17:1971-1977
Increased DNA-protein cross-linking (DPX) in circulating leukocytes has been proposed as a potential biomarker for exposure and genotoxic damage caused by inhalation of certain reactive chemicals, such as hexavalent chromium [Cr(VI)]. This study was
Publikováno v:
Metabolic Brain Disease. 9:143-152
Organic acidemia is found in several metabolic encephalopathies (e.g., hepatic and valproate encephalopathies, Reye's syndrome, and hereditary organic acidemias). Although fatty acids are known to be neurotoxic, the underlying mechanisms have not bee
Publikováno v:
Drug and chemical toxicology. 30(1)
Exposure to aldehydes represents potential risks to human and animal health. Cyclic aldehydes such as benzaldehyde, 2-furaldehyde, and paraldehyde were found to induce formation of stable DNA-protein cross-links (DPXs) in cultured human lymphoma cell
Publikováno v:
Biopharmaceuticsdrug disposition. 20(9)
A three-way crossover study in 18 healthy male volunteers was conducted to evaluate the bioequivalence of three different 200 mg anhydrous theophylline immediate-release (IR) capsules. The products had not been rated as therapeutically equivalent by
Autor:
M C, Meyer, A B, Straughn, E J, Jarvi, K S, Patrick, F R, Pelsor, R L, Williams, R, Patnaik, M L, Chen, V P, Shah
Publikováno v:
Pharmaceutical research. 17(4)
To determine the relative bioavailability of two marketed, immediate-release methylphenidate tablets. The study used a replicated study design to characterize intrasubject variability, and determine bioequivalence using both average and individual bi
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 23(12)
Mexiletine and tocainide are lidocaine congeners that share similar chemical structures. Clinical studies suggest that the in vivo inhibitory effect of mexiletine on the CYP1A family of isoforms is substantially greater than that of tocainide. We inv
Publikováno v:
Surgery. 115(3)
Previous work documented a 40% depression of hepatic indocyanine green (ICG) clearance (ClICG) in pigs fasted to 20% weight loss, with return to normal within 12 days of food refeeding. ClICG in pigs is insensitive to changes in hepatic blood flow bu
Publikováno v:
Research communications in chemical pathology and pharmacology. 82(3)
We investigated the hypothesis that one mechanism underlying fatty acid toxicity is the selective inhibition of rate-limiting and/or regulated tricarboxylic acid cycle and related enzymes by fatty acyl coenzyme A (CoA) derivatives by examining the ef
Publikováno v:
American journal of hospital pharmacy. 50(12)