Zobrazeno 1 - 10
of 326
pro vyhledávání: '"E. Jähnchen"'
Publikováno v:
Arzneimittelforschung. 51:891-895
The effect of the non-steroidal anti-inflammatory drug lysine clonixinate ([2-(3-chloro-o-toluidino)nicotinic acid]-L-lysinate, CAS 55837-30-4) on the pharmacokinetics and anticoagulant activity of phenprocoumon (4-hydroxy-3-(1-phenylpropyl)-coumarin
Autor:
Heikki Vapaatalo, Riitta Korpela, Salme Järvenpää, Pauliina I. Ehlers, Frank Wagner, E. Jähnchen, Anne S. Kivimäki, Erol Wiegert, Anu M. Turpeinen, Iris Filler
Publikováno v:
Clinical and Experimental Hypertension. 33:388-396
Casein-derived tripeptides isoleucine-proline-proline (Ile-Pro-Pro) and valine-proline-proline (Val-Pro-Pro) lower blood pressure (BP) in long-term clinical studies. Their acute effects on BP and vascular function, important for daily dosing scheme,
Publikováno v:
The Journal of Clinical Pharmacology. 41:79-84
The aim of the present study was to investigate the pharmacokinetics of tilidine and its metabolites during the dialysis procedure and in the dialysis-free interval. Tilidine is a prodrug that is metabolized presystemically into the active metabolite
Publikováno v:
The Journal of Clinical Pharmacology. 40:168-176
In this double-blind, randomized, placebo-controlled cross-over study, the authors investigated the initial time course of effects of isosorbide-5-mononitrate (IS-5-MN) on hemodynamic parameters in 15 healthy male volunteers after administering a sin
Autor:
Kurt Löffler, G. Ruf, N. de la Rey, S. Gera, H. G. Luus, W. Schulz, Dietmar Trenk, E. Jähnchen
Publikováno v:
European Journal of Clinical Pharmacology. 46:545-550
The pharmacokinetics and pharmacodynamics of single oral doses of 5 mg ramipril and 6 mg piretanide administered separately and in combination were determined in a single blind, randomised, 3-period cross-over study in 24 healthy male volunteers. The
Publikováno v:
International Journal of Cardiology. 43:279-285
The anti-ischemic effect of 5 mg nebivolol o.i.d., a newly developed β 1 -selective adrenoceptor blocking drug with vasodilating properties, was compared with that of atenolol (100 mg o.i.d.) following a treatment period of 6 days. The study was per
Autor:
E. Jähnchen, K. Schnellbacher, A. Rehe, R. Bonn, Dietmar Trenk, M. Buschmann, A. Wiegand, Helmut Roskamm
Publikováno v:
European Journal of Clinical Pharmacology. 44:451-456
The time course and the magnitude of the effect of glyceryl trinitrate (GTN) on central venous (pulmonary artery diastolic pressure-PAPd) and peripheral arterial (a/b-ratio of the finger pulse wave) haemodynamics were compared in a randomized double-
Publikováno v:
The Journal of Clinical Pharmacology. 33:513-521
Anecdotal reports from clinical trials assessing the use of cyclosporine in the treatment of rheumatoid arthritis suggest an association between enhanced renal impairment and combined use of cyclosporine with nonsteroidal anti-inflammatory drugs. To
Autor:
Stefan Szathmary, Dietmar Trenk, Monika Buschmann, Hans-Peter Benn, Klaus-Ulrich Seiler, E. Jähnchen
Publikováno v:
The Journal of Clinical Pharmacology. 33:330-334
The effects of concurrent administration of either cimetidine 800 mg once daily or ranitidine 300 mg once daily on the single-dose pharmacokinetics of ritanserin 10 mg were investigated in an open, randomized three-way cross-over, controlled investig