Výsledky vyhledávání - "E. I. Korotkevich"

Predict of metabolic stability of xenobiotics by the PASS and GUSAR programs

Autor: Dmitrii Filimonov, E. I. Korotkevich, Alexey Lagunin, Alexander V. Dmitriev, A. V. Rudik

Publikováno v: Biomeditsinskaya Khimiya. 67:295-299

Metabolic stability refers to the susceptibility of compounds to the biotransformation; it is characterized by such pharmacokinetic parameters as half-life (T1/2) and clearance (CL). Generally, these parameters are estimated by in vitro assays, which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f46575b648cf9ef42e5538fd381cee91
https://doi.org/10.18097/pbmc20216703295

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Blood Plasma Lipidome: Opportunities in the Early Diagnostics of Preeclampsia

Autor: T. I. Torkhovskaya, T S Zakharova, S. S. Markin, N. K. Kasum-zade, R. I. Shalina, E I Korotkevich

Publikováno v: Russian Journal of Bioorganic Chemistry. 46:280-286

Blood plasma lipidome analysis is a mass spectrometric (MS) evaluation of molecular types of lipids, sometimes in combination with high performance liquid chromatography (HPLC). Its importance is increasing in studies aimed at identifying new informa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2e71f8487a24a1903a62e10a1c0451f6
https://doi.org/10.1134/s1068162020030206

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Nanoliposomes as drug delivery systems: safety concerns

Autor: E I Korotkevich, L V Kostryukova, E. F. Kolesanova, T. I. Torkhovskaya, M.A. Sanzhakov, N A Orlova, E G Tikhonova, Yu.A. Tereshkina, Yu.Yu. Khudoklinova

Publikováno v: Journal of drug targeting. 30(3)

The review highlights the safety issues of drug delivery systems based on liposomes. Due to their small sizes (about 80-120 nm, sometimes even smaller), phospholipid nanoparticles interact intensively with living systems during parenteral administrat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9e1bd808b1ab9f5265257f69628b6c8
https://pubmed.ncbi.nlm.nih.gov/34668814

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Human Blood Plasma Lipidome: Opportunities and Prospects of Its Analysis in Medical Chemistry

Autor: T. I. Torkhovskaya, E I Korotkevich, S. S. Markin, T S Zakharova, O. M. Ipatova

Publikováno v: Russian Journal of Bioorganic Chemistry. 45:335-346

The emerging development of new analytical mass spectrometry technologies resulted in the possibility of a detailed fractionation of biologically important compounds. As applied to lipids, it promoted the development of opportunities for identificati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c248feb66105f6442b5b36b1c638f353
https://doi.org/10.1134/s106816201905011x

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Preclinical Study of Pharmacological Properties of Doxorubicin-NPh

Autor: J A Tereshkina, E. G. Tikhonova, J. B. Venediktova, A. A. Pankratov, E I Korotkevich, E R Nemtsova, O. A. Bezborodova, L V Kostryukova

Publikováno v: Bulletin of experimental biology and medicine. 169(6)

Preclinical study of therapeutic properties of an innovative drug Doxorubicin-NPh (doxorubicin in the form of ultrafine suspension of phospholipid liposomes) in comparison with free doxorubicin (Doxorubicin-Teva) and protected doxorubicin (Caelyx) wa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59078b685138b345899efcecf031bea6
https://pubmed.ncbi.nlm.nih.gov/33123920

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[Chlorine e6 in phospholipid nanoparticles with specific targeting and penetrating peptides as prospective composition for photodynamic therapy of malignant neoplasms]

Autor: T I Torkhovskaya, L V Kostryukova, E I Korotkevich, Yu A Teryoshkina, A D Plyutinskaya, A A Pankratov, E. G. Tikhonova, V.N. Prozorovskiy

Publikováno v: Biomeditsinskaia khimiia. 65(6)

Cytotoxic and photoinduced activity of chlorine e6 (Ce6) in phospholipid nanoparticles with specific tumor targeting and cell-penetrating peptides was studied in vitro using human fibrosarcoma cells HT-1080. It was shown, that the binding of cell-pen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12269bf77bda29917a8f8deb20a8d07c
https://pubmed.ncbi.nlm.nih.gov/31876521

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Composite phospholipid-gold nanoparticles with targeted fragment for tumor imaging

Autor: Yu.A. Tereshkina, E G Tikhonova, Tatiana I. Torkhovskaya, K.K. Baskaev, Vasily A Kudinov, E I Korotkevich, Galina E. Morozevich, D.S. Stepanova, M.A. Sanzhakov

Publikováno v: Biomedicine & Pharmacotherapy, Vol 142, Iss, Pp 111985-(2021)

Gold nanoparticles and their conjugates have significant potential in the field of diagnosis of various diseases due to their SPR, which enhances light scattering and absorption. Conjugates of gold nanoparticles with various ligands can be used for i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2c6c1de8eb7e135dc545453d1732d4a
https://doi.org/10.1016/j.biopha.2021.111985

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Preparation and Properties of Antitumor Drug Based on Lipid Derivative of Sarcolysin

Autor: V.N. Prozorovsky, A.A. Chistov, Yu.A. Tereshkina, E I Korotkevich, E G Tikhonova, O.M. Ipatova, M.A. Sanzhakov, L V Kostryukova

Publikováno v: Biomedical Chemistry: Research and Methods; Vol. 2 No. 3 (2019); e00098
Biomedical Chemistry: Research and Methods; Том 2 № 3 (2019); e00098
Biomedical Chemistry: Research and Methods

The conditions for the preparation of a drug formulations based on the lipid derivative of sarcolysin embedded in phospholipid nanoparticles have been optimized. The drug is an ultra-thin emulsion with a light transmittance above 80% and a particle s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0eb8367376e78d8898e70f8de95b2d7
http://www.bmc-rm.org/index.php/bmcrm/article/view/98

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