Zobrazeno 1 - 10
of 141
pro vyhledávání: '"E. Hyytinen"'
Autor:
J. Isola, E. Hyytinen, Pasi A. Koivisto, Teuvo L.J. Tammela, Olli Kallioniemi, C. Palmberg, Tapio Visakorpi
Publikováno v:
European Urology. 31:216-219
Objective We recently found amplification of the androgen receptor (AR) gene in approximately 30% of locally recurrent prostate carcinomas from patients treated by conventional androgen deprivation (castration) therapy, whereas none of the untreated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e5b40a69d0acebd25cd828c911342d5
https://doi.org/10.1159/000474453
https://doi.org/10.1159/000474453
Publikováno v:
British Journal of Cancer
Recent studies suggest that aberrations of c-erbB-2 may be involved in astrocytic brain tumours. We screened immunohistochemically c-erbB2 protein (p185) expression in 94 astrocytic grade 1-4 neoplasms of the brain. The amplification of the c-erbB-2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::389d13fa9f3f5914c47ce60df01e3bb9
https://doi.org/10.1038/bjc.1996.107
https://doi.org/10.1038/bjc.1996.107
Publikováno v:
Cytometry. 16:93-99
Fluorescence in situ hybridization (FISH) and specific DNA probes for peri-centromeric repeat regions and unique sequence loci have made it possible to study chromosomal aberrations from interphase tumor nuclei. Large-scale retrospective studies on t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b63ea84fb043e26f82fedd55d6915cb
https://doi.org/10.1002/cyto.990160202
https://doi.org/10.1002/cyto.990160202
Autor:
Pasi A. Koivisto, Kyllikki Haapala, E. Hyytinen, Tuula Kuukasjärvi, Heikki Helin, Immo Rantala
Publikováno v:
Human pathology. 38(3)
Mechanisms of prostate cancer progression during hormonal therapy and the pathobiologic consequences of androgen receptor (AR) gene amplification are inadequately known. To further investigate the hypothesis that AR gene amplification is associated w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adcc2e7cf279ddd513cccbabf8dbed11
https://pubmed.ncbi.nlm.nih.gov/17217995
https://pubmed.ncbi.nlm.nih.gov/17217995
Autor:
Robert L. Vessella, Ceshi Chen, Xiaodong Sun, Heikki Helin, Jin-Tang Dong, E. Hyytinen, Henry F. Frierson, Pasi A. Koivisto
Publikováno v:
The American journal of pathology. 162(4)
Kruppel-like factors (KLFs) are a group of transcription factors that appear to be involved in different biological processes including carcinogenesis. In a recent study, KLF6 was reported as a tumor suppressor gene in prostate cancer because of its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::701a7998c7573bf2b0279d6aa2d1f628
https://pubmed.ncbi.nlm.nih.gov/12651597
https://pubmed.ncbi.nlm.nih.gov/12651597
Autor:
Pasi A. Koivisto, Rega Saadut, E. Hyytinen, Robert L. Vessella, Lindsay Paull, Jin-Tang Dong, Henry F. Frierson, Ceshi Chen
Publikováno v:
Genes, chromosomescancer. 34(3)
Deletion of the long arm of chromosome 6 (6q) frequently occurs in many neoplasms, including carcinomas of the prostate and breast and melanoma, suggesting the location of a tumor-suppressor gene or genes at 6q. At present, however, the region of del
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21f5dca8808f98eeb95810a1b6a2f661
https://pubmed.ncbi.nlm.nih.gov/12007191
https://pubmed.ncbi.nlm.nih.gov/12007191
Autor:
Pasi A. Koivisto, Teuvo L.J. Tammela, C. Palmberg, Marita Laurila, Kyllikki Haapala, E. Hyytinen, Annika Rökman
Publikováno v:
Cancer genetics and cytogenetics. 131(1)
The genetic mechanisms of prostate cancer recurrence during hormonal therapy are largely unknown. So far, data from conventional karyotype analysis on hormone-refractory prostate carcinomas have not been published, mainly because of the difficulties
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72ab4c3db85cf759bb1210be1f0e0c0f
https://pubmed.ncbi.nlm.nih.gov/11734323
https://pubmed.ncbi.nlm.nih.gov/11734323
Publikováno v:
Cancer genetics and cytogenetics. 101(1)
Recent studies have identified several chromosomal regions that are altered in prostate cancer. However, the specific genes affected are, in most of the cases, not known. Cancer cell lines could provide a valuable resource for cloning of genes that a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::906b286a97c8d6efa4ca04854e0d60fd
https://pubmed.ncbi.nlm.nih.gov/9460501
https://pubmed.ncbi.nlm.nih.gov/9460501
Publikováno v:
The American journal of pathology. 147(6)
The molecular mechanisms and genetic changes that lead to the progression of prostate cancer during endocrine therapy are poorly characterized. Here, paired specimens from both untreated primary tumors and from local recurrences were collected from 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1593f74a708f568c62f295e53e91f973
https://pubmed.ncbi.nlm.nih.gov/7495286
https://pubmed.ncbi.nlm.nih.gov/7495286
Autor:
Pasi A. Koivisto, Jorma Isola, Riitta Keinänen, E. Hyytinen, C. Palmberg, Tapio Visakorpi, Aarno Palotie, Teuvo L.J. Tammela, Olli-P. Kallioniemi, Minna Tanner
Publikováno v:
Nature genetics. 9(4)
Overexpression of amplified genes is often associated with the acquisition of resistance to cancer therapeutic agents in vitro. We have identified a similar molecular mechanism in vivo for endocrine treatment failure in human prostate cancer which in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34041c8718bffff8493c78923489a14c
https://pubmed.ncbi.nlm.nih.gov/7795646
https://pubmed.ncbi.nlm.nih.gov/7795646