Zobrazeno 1 - 10
of 171
pro vyhledávání: '"E. Handel"'
Autor:
Sophie N. M. Binks, Michele Veldsman, Adam E. Handel, Saiju Jacob, Paul Maddison, Jan Coebergh, Sophia Michael, Sudarshini Ramanathan, Ava Easton, Mette Scheller Nissen, Maria Isabel Leite, David Okai, Morten Blaabjerg, Masud Husain, Sarosh R. Irani
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 11, Iss 4, Pp 1053-1058 (2024)
Abstract Patient‐reported quality‐of‐life (QoL) and carer impacts are not reported after leucine‐rich glioma‐inactivated 1‐antibody encephalitis (LGI1‐Ab‐E). From 60 patients, 85% (51 out of 60) showed one abnormal score across QoL as
Externí odkaz:
https://doaj.org/article/273c8826b6844ccca7c5c709b65611ce
Autor:
Fabian Klein, Clara Veiga-Villauriz, Anastasiya Börsch, Stefano Maio, Sam Palmer, Fatima Dhalla, Adam E. Handel, Saulius Zuklys, Irene Calvo-Asensio, Lucas Musette, Mary E. Deadman, Andrea J. White, Beth Lucas, Graham Anderson, Georg A. Holländer
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract The network of thymic stromal cells provides essential niches with unique molecular cues controlling T cell development and selection. Recent single-cell RNA sequencing studies have uncovered previously unappreciated transcriptional heteroge
Externí odkaz:
https://doaj.org/article/58106d4dcccf4fdebf3a90d5d836fcdb
Autor:
Jimena Monzón-Sandoval, Elena Burlacu, Devika Agarwal, Adam E. Handel, Liting Wei, John Davis, Sally A. Cowley, M. Zameel Cader, Caleb Webber
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 10 (2022)
Externí odkaz:
https://doaj.org/article/71d2d166952149deaacfd3fb1e483bae
Autor:
Bergithe E. Oftedal, Stefano Maio, Adam E. Handel, Madeleine P. J. White, Duncan Howie, Simon Davis, Nicolas Prevot, Ioanna A. Rota, Mary E. Deadman, Benedikt M. Kessler, Roman Fischer, Nikolaus S. Trede, Erdinc Sezgin, Rick M. Maizels, Georg A. Holländer
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Oftedal et al. generate mice lacking the chaperonin subunit CCT8 in T cells. They find that loss of CCT8 leads to reduced formation of nuclear actin filaments, changes in proteostasis, defective Th2 cell polarization and T cell metabolism and a faile
Externí odkaz:
https://doaj.org/article/f3b7f22ef77541f089085a26cdea4934
Autor:
Thomas Barthlott, Adam E. Handel, Hong Ying Teh, Rushika C. Wirasinha, Katrin Hafen, Saulius Žuklys, Benoit Roch, Stuart H. Orkin, Jean-Pierre de Villartay, Stephen R. Daley, Georg A. Holländer
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Development of the T cells requires functions from thymic epithelial cells, whose development and function are epigenetically regulated. Here the authors show that inactivation of the polycomb repressive complex 2 (PRC2) alters the H3K27me3 configura
Externí odkaz:
https://doaj.org/article/bea5fbe30e2340e383f4864410b7a2fd
Autor:
Jeanette Baran-Gale, Michael D Morgan, Stefano Maio, Fatima Dhalla, Irene Calvo-Asensio, Mary E Deadman, Adam E Handel, Ashley Maynard, Steven Chen, Foad Green, Rene V Sit, Norma F Neff, Spyros Darmanis, Weilun Tan, Andy P May, John C Marioni, Chris P Ponting, Georg A Holländer
Publikováno v:
eLife, Vol 9 (2020)
Ageing is characterised by cellular senescence, leading to imbalanced tissue maintenance, cell death and compromised organ function. This is first observed in the thymus, the primary lymphoid organ that generates and selects T cells. However, the mol
Externí odkaz:
https://doaj.org/article/0801b66fbced40e4a16cb9a6776b1379
Autor:
Jimena Monzón-Sandoval, Elena Burlacu, Devika Agarwal, Adam E. Handel, Liting Wei, John Davis, Sally A. Cowley, M. Zameel Cader, Caleb Webber
Alzheimer's disease (AD) is the most common form of dementia, and risk-influencing genetics implicates microglia and neuroimmunity in the pathogenesis of AD. Induced pluripotent stem cell (iPSC)-derived microglia (iPSC-microglia) are increasingly use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f854a05c4d2bd33600dbf30d9c35f258
https://ora.ox.ac.uk/objects/uuid:52c960f8-01b6-40da-a180-17acf81b6fcd
https://ora.ox.ac.uk/objects/uuid:52c960f8-01b6-40da-a180-17acf81b6fcd
Changes in the rate of leucine-rich glioma-inactivated 1 seropositivity during the COVID-19 lockdown
Several reports suggest autoantibody-associated neurologic conditions, such as autoimmune encephalitis and myelin-oligodendrocyte glycoprotein (MOG) antibody–associated diseases, may be triggered by the COVID-19 pandemic and associated vaccinations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f2e1ea44cc8841319b7d50ed8871147
https://doi.org/10.1001/jamaneurol.2022.5346
https://doi.org/10.1001/jamaneurol.2022.5346
Autor:
Adam E. Handel, Noriko Shikama-Dorn, Saule Zhanybekova, Stefano Maio, Annina N. Graedel, Saulius Zuklys, Chris P. Ponting, Georg A. Holländer
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Thymic epithelial cells (TEC) effect crucial roles in thymopoiesis including the control of negative thymocyte selection. This process depends on their capacity to express promiscuously genes encoding tissue-restricted antigens. This competence is ac
Externí odkaz:
https://doaj.org/article/60171e438a3e41e1b78f9e333d9ba87b
Autor:
Caleb Webber, Colin J. Akerman, Sarah E. Newey, Viola Volpato, Michael B. Clark, Rory Bowden, Emma S. Whiteley, Adam E. Handel, M. Zameel Cader, Fabiola Curion, Alexandra Pokhilko, Sunniva Bostrand
Publikováno v:
Genome Research
Genome Res
Genome Res
Single-cell RNA sequencing (scRNA-seq) is a widely used method for identifying cell types and trajectories in biologically heterogeneous samples, but it is limited in its detection and quantification of lowly expressed genes. This results in missing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffc5f001d2518f09686e4d4de77e4a18
https://doi.org/10.1101/gr.273961.120
https://doi.org/10.1101/gr.273961.120