Busulfan target exposure attainment in children undergoing allogeneic hematopoietic cell transplantation: a single day versus a multiday therapeutic drug monitoring regimen

Autor: T. Bognàr, J. S. Kingma, E. H. Smeijsters, K. C. M. van der Elst, C. T. M. de Kanter, C. A. Lindemans, A. C. G. Egberts, I. H. Bartelink, A. Lalmohamed

Publikováno v: Bone Marrow Transplantation. Nature Publishing Group
Bognàr, T, Kingma, J S, Smeijsters, E H, van der Elst, K C M, de Kanter, C T M, Lindemans, C A, Egberts, A C G, Bartelink, I H & Lalmohamed, A 2023, ' Busulfan target exposure attainment in children undergoing allogeneic hematopoietic cell transplantation : a single day versus a multiday therapeutic drug monitoring regimen ', Bone Marrow Transplantation, vol. 58, no. 7, pp. 762-768 . https://doi.org/10.1038/s41409-023-01971-z

Busulfan exposure has previously been linked to clinical outcomes, hence the need for therapeutic drug monitoring (TDM). Study objective was to evaluate the effect of day 1 TDM-guided dosing (regimen d1) versus days 1 + 2 TDM-guided dosing (regimen d

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https://research.vumc.nl/en/publications/5527bccd-ce9f-4256-a4bf-93e1a93712dc