Zobrazeno 1 - 10
of 29
pro vyhledávání: '"E. H. Field"'
Publikováno v:
The Journal of Immunology. 151:48-59
Although distinct Th1 and Th2 CD4+ subsets are apparent in in vitro studies, controversy exists over whether these subsets occur functionally in vivo. We describe a patient whose presenting laboratory features of elevated IgG4 and IgE and eosinophili
Publikováno v:
The Journal of Immunology. 149:1131-1137
Complete elimination of CD4 cells by in vivo treatment with anti-CD4 mAb may result in B cell polyclonal activation. Additionally, mice treated with doses of anti-CD4 that eliminate half the CD4 cells produced higher anti-SRBC antibody responses than
Autor:
E H Field, G C Becker
Publikováno v:
The Journal of Immunology. 148:354-359
Treatment with total lymphoid irradiation (TLI) before organ transplantation results in high incidences of donor-specific tolerance. However, the exact mechanism of how TLI induces or maintains tolerance is not known. In many experimental systems of
Publikováno v:
Immunological reviews. 182
Tolerance to self-antigens is an ongoing process that begins centrally during T-cell maturation in the thymus and continues throughout the cell's life in the periphery by a network of regulated restraints. Remaining self-reactive T-cells that escape
Publikováno v:
Transplantation. 68(12)
Injection of neonatal BALB/c mice with semi-allogeneic splenocytes leads to antigen-specific tolerance lasting into adulthood. Tolerant mice accept A/J skin grafts and fail to generate CD8 cytotoxic T lymphocyte (CTL) activity against A/J targets. An
Publikováno v:
Transplantation. 64(1)
In the past, tolerance mechanisms have focused on processes that involve elimination (deletion) or paralysis (anergy) of immune responses. It is now becoming clearer that peripheral tolerance to antigen depends on the generation of regulatory cells t
Publikováno v:
Transplantation. 62(12)
We previously reported that prolonged graft survival in neonatally tolerant mice was associated with enhanced Th2/Th1 cytokines. To determine whether Th2 CD4 cells function in tolerance, we examined whether we could prevent tolerance by blocking Th2
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 157(9)
Mice given total lymphoid irradiation (TLI) can be tolerized by an incompletely understood mechanism to foreign Ags given during a brief window of time immediately after completing radiation. We previously showed that splenocytes taken from mice imme
Publikováno v:
Transplantation. 61(7)
We investigated the role of Th1 ad Th2 cytokines in rejection and tolerance using the neonatal tolerance model. We reported previously that lymph nodes that drained immunogen-bearing tolerant grafts produced a 10- to 100-fold higher ratio of interleu
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 152(2)
Anti-CD4 has been extensively studied in murine models of autoimmunity and transplantation. The timing of anti-CD4 administration in these systems is critical because anti-CD4 effectively blocks primary T-dependent responses but does not diminish ong