Zobrazeno 1 - 8
of 8
pro vyhledávání: '"E. H. Banitt"'
Publikováno v:
Journal of Medicinal Chemistry. 20:821-826
Benzamides characterized by one or more 2,2,2-trifluoroethoxy ring substituents and a heterocyclic amide side chain have been prepared and evaluated for oral antiarrhythmic activity in mice. The most potent compounds are derived from 2,5-bis(2,2,2-tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9b9adb4bb60eeb1c60cc9f98f20d6d4
https://doi.org/10.1021/jm00216a016
https://doi.org/10.1021/jm00216a016
Autor:
E. H. Banitt, G. J. Conard
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 18:713-720
N-(2-Piperidylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide acetate (flecainide acetate; R-818), a new antiarrhythmic agent, was labelled with carbon-14 at the carboxamide position for metabolic studies. A three-step synthetic route starting from 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c16ae69c6df35afd58a01b475a94c76
https://doi.org/10.1002/jlcr.2580180513
https://doi.org/10.1002/jlcr.2580180513
Publikováno v:
Journal of Medicinal Chemistry. 18:1130-1134
Benzamides and naphthamides characterized by one or more 2,2,2-trifluoroethoxy ring substituents have been prepared and evaluated as antiarrhythmic agents in mice. Structure-action studies reveal that antiarrhythmic activity is highly dependent upon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f051a3c07a32a838370d01c511cdd1e9
https://doi.org/10.1021/jm00245a017
https://doi.org/10.1021/jm00245a017
Publikováno v:
Chemischer Informationsdienst. 7
Benzamides and naphthamides characterized by one or more 2,2,2-trifluoroethoxy ring substituents have been prepared and evaluated as antiarrhythmic agents in mice. Structure-action studies reveal that antiarrhythmic activity is highly dependent upon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::156344526ce61fef05daa07035b2eda4
https://doi.org/10.1002/chin.197608126
https://doi.org/10.1002/chin.197608126
Autor:
R L, McQuinn, G J, Quarfoth, J D, Johnson, E H, Banitt, S V, Pathre, S F, Chang, R E, Ober, G J, Conard
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 12(4)
The metabolism of 14C-flecainide acetate, a new antiarrhythmic, was investigated in four healthy human subjects, after a single, 200-mg oral dose. The cumulative recovery of radioactivity ranged from 81 to 90% (mean, 86%) in urine and from 4 to 6% (m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b817388ce6ed8081a0c1e2386ade2f8d
https://pubmed.ncbi.nlm.nih.gov/6148206
https://pubmed.ncbi.nlm.nih.gov/6148206
Publikováno v:
Journal of medicinal chemistry. 17(1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82c5adfc0de9b1c9c5c52ea4e80321c0
https://pubmed.ncbi.nlm.nih.gov/4148420
https://pubmed.ncbi.nlm.nih.gov/4148420
Publikováno v:
Chemischer Informationsdienst. 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::425ccef75dff1301d4d4d132af4c92bb
https://doi.org/10.1002/chin.197420279
https://doi.org/10.1002/chin.197420279
Publikováno v:
Chemischer Informationsdienst. 8
Benzamides characterized by one or more 2,2,2-trifluoroethoxy ring substituents and a heterocyclic amide side chain have been prepared and evaluated for oral antiarrhythmic activity in mice. The most potent compounds are derived from 2,5-bis(2,2,2-tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8ecfb7f7474155143c74c08ec6d1a84
https://doi.org/10.1002/chin.197742198
https://doi.org/10.1002/chin.197742198