Zobrazeno 1 - 10
of 217
pro vyhledávání: '"E. Gutteridge"'
Autor:
Fiona Macintyre, Hanu Ramachandruni, Jeremy N. Burrows, René Holm, Anna Thomas, Jörg J. Möhrle, Stephan Duparc, Rob Hooft van Huijsduijnen, Brian Greenwood, Winston E. Gutteridge, Timothy N. C. Wells, Wiweka Kaszubska
Publikováno v:
Malaria Journal, Vol 17, Iss 1, Pp 1-18 (2018)
Abstract Over the last 15 years, the majority of malaria drug discovery and development efforts have focused on new molecules and regimens to treat patients with uncomplicated or severe disease. In addition, a number of new molecular scaffolds have b
Externí odkaz:
https://doaj.org/article/dbdcceb481fa497fa620c83328de23ba
Autor:
David A. Baker, Lindsay B. Stewart, Jonathan M. Large, Paul W. Bowyer, Keith H. Ansell, María B. Jiménez-Díaz, Majida El Bakkouri, Kristian Birchall, Koen J. Dechering, Nathalie S. Bouloc, Peter J. Coombs, David Whalley, Denise J. Harding, Ela Smiljanic-Hurley, Mary C. Wheldon, Eloise M. Walker, Johannes T. Dessens, María José Lafuente, Laura M. Sanz, Francisco-Javier Gamo, Santiago B. Ferrer, Raymond Hui, Teun Bousema, Iñigo Angulo-Barturén, Andy T. Merritt, Simon L. Croft, Winston E. Gutteridge, Catherine A. Kettleborough, Simon A. Osborne
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Protein kinases are promising drug targets for treatment of malaria. Here, starting with a medicinal chemistry approach, Baker et al. generate an imidazopyridine that selectively targets Plasmodium falciparum PKG, inhibits blood stage parasite growth
Externí odkaz:
https://doaj.org/article/0c48607312374096801bf91f077ff9c0
Autor:
Jeremy N. Burrows, Stephan Duparc, Winston E. Gutteridge, Rob Hooft van Huijsduijnen, Wiweka Kaszubska, Fiona Macintyre, Sébastien Mazzuri, Jörg J. Möhrle, Timothy N. C. Wells
Publikováno v:
Malaria Journal, Vol 16, Iss 1, Pp 1-5 (2017)
Externí odkaz:
https://doaj.org/article/0db67e0cbf7c4a8ba7a34e1ed7147e7b
Autor:
Clare E. Gutteridge, Brett W. Sadowski, Stephen M. Hughes, J. Alan Friedlander, Alicia D. Gaidry, Michael C. Baxter, Matthew B. Smith, Leighton G. Rodrigo, Michael T. O'Neil, Lucia Gerena, Patricia J. Lee, Ramadas Sathunuru, Montip Gettayacamin
Publikováno v:
Medicinal chemistry (Shariqah (United Arab Emirates)).
Objective: A series of novel, substituted tetracyclic benzothiazepines were designed and prepared in an effort to optimize potency of this chemical class against drug-resistant strains of the malaria parasite. Method: Tetracyclic benzothiazepines bea
Autor:
Karen-Ann Gray, Karryn J Gresty, Nanhua Chen, Veronica Zhang, Clare E Gutteridge, Christopher L Peatey, Marina Chavchich, Norman C Waters, Qin Cheng
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0157906 (2016)
Artemisinin-induced dormancy provides a plausible explanation for recrudescence following artemisinin monotherapy. This phenomenon shares similarities with cell cycle arrest where cyclin dependent kinases (CDKs) and cyclins play an important role.Tra
Externí odkaz:
https://doaj.org/article/e4e8b480e65f49d88f561c6bd5643513
Autor:
J. Alan Friedlander, Brett W. Sadowski, Nathan C. Lorei, Michael C. Baxter, Stephen M. Hughes, Michael T. O’Neil, Leighton G. Rodrigo, Clare E. Gutteridge, Jonathan E. Harrell
Publikováno v:
International Journal of Organic Chemistry. 10:123-134
A versatile synthetic approach toward a series of benzothiazepines with medicinal potential (for example, compound 1) that allows incorporation of structural variation at the three aromatic regions of the structure, and at the sulfur atom, was develo
Akademický článek
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Autor:
Shelley Potter, Elizabeth J Conroy, Ramsey I Cutress, Paula R Williamson, Lisa Whisker, Steven Thrush, Joanna Skillman, Nicola L P Barnes, Senthurun Mylvaganam, Elisabeth Teasdale, Abhilash Jain, Matthew D Gardiner, Jane M Blazeby, Chris Holcombe, R Achuthan, I Adwan, S Aggarwal, M Ahmed, M Akelund, D Akolekar, O Al-Jibury, M Amanita, D Appleton, D Archampong, K Asgiersson, R Athwal, A Augusti, S Ayaani, S Bains, B Baker, E Baker, S Baldota, D Banerjee, S Barker, L Barr, P Barry, N Basu, S Bathla, N Bishop, G Boland, O A Branford, R Bright-Thomas, R Brindle, L Brock, V Brown, F Bux, G Byrne, H Cain, L Caldon, M Callaghan, A Carbone, R Carpenter, S Cawthorn, L Chagla, T Challoner, C Chalmers, R Chalmers, S Chambers, M Chana, N Chand, V Chandran, M Chandrashekar, H Charfare, J Chatterjee, S Chatterjee, R Chattopadhyay, A Chaudry, K Chin, K Chong, A Chouhan, C Choy, P Christopoulos, D Clarke, S Clarke, E Clayton, R Clifford, D Cocker, T Collin, N Collis, F Conroy, C Constantinou, A Conway, J Cook, N Coombs, K Cox, A Critchley, M Dakka, M Dani, R Daoud, L Darragh, S Darvesh, I Dash, S Datta, E Davies, S Dawson, E De Sousa, D Debnath, H Deol, H Devalia, R Di Micco, JR Dicks, J Dickson, N Dobner, G Dobson, N Dunne, D Egbeare, D El Sharief, D Elfadl, E Eltigani, D Enver, E Erel, A Evans, G Exarchos, E Fage, H Fatayer, C Fenn, D Ferguson, R Foulkes, J Franks, V Fung, M Galea, T Gandamihardja, A Gandhi, C Garnsey, C Gateley, J Gattuso, S Gawne, N Geerthan, A Ghattura, A Giaramadze, J Gill, AR Godden, S Goh, S Govindarajulu, S Goyal, T Graja, S Granger, M Green, K Grover, G Gui, R Gurung, E Gutteridge, A Hakim, A Halka, W Hamilton-Burke, I Hamo, C Harding-Mackean, A Hargreaves, S Harries, K Harris, P Harris, S Harrison, J Harvey, M Hashem, U Hassan, J Henderson, J Henton, S Hignett, K Hodgkins, K Horgan, S Horn, J Hu, A Hussain, J Iddon, A Iqbal, R Irri, T Irvine, G Irwin, A Iskender, A Ismail, C Ives, K James, R James, N Jiwa, M Jobson, S Joglekar, L Johnson, R Johnson, L Jones, M Ju Hwang, V Kalles, K Kanesalingam, I Karat, M Kaushik, K Kennedy, E Khalifa, H Khan, M Khanbhai, S Khawaja, H Khout, T Kiernan, B Kim, K Kirkpatrick, P Kiruparan, C Kirwan, M Kishore, P Kneeshaw, A Knight, S Kohlhardt, J Krupa, K Krupa, R Kuruvilla, C Laban, LM Lai, I Laidlaw, K Lambert, F Langlands, M Lansdown, N Laurence, S Laws, S Ledwidge, V Lefemine, H Lennon, R Linforth, K Little, A Luangsomboon, J Lund, J Maalo, L MacLennan, RD Macmillan, F MacNeil, TK Mahapatra, E Mallidis, P Mallon, N Manoloudakis, L Maraqa, S Marla, S Masood, J Massey, T Masudi, P Matey, F Mazari, S McCulley, K McEvoy, J Mcintosh, S McIntosh, S McKenzie, P McManus, J McNicholas, I Michalakis, N Mills, G Mitchell, S Monib, M Mullan, C Murphy, G Murphy, J Murphy, B Murthy, S Musa, G Nagra, R Nangalia, S Narayanan, R Nasr, C Navin, R Newton, S Nicholson, N Nuru, R O'Connell, J O'Donoghue, A Ogedegbe, OS Olayinka, S Olsen, G Osborn, C Osborne, H Osman, C Otieno, F Pakzad, A Park, S Parker, P Partlett, A Parvaiz, L Parvanta, G Patel, A Peel, L Peiris, M Pennick, A Peppe, D Perry, S Pilgrim, J Piper, S Poonawalla, E Popa, V Pope, P Pugh, D Rainsbury, K Ramsey, T Rasheed, R Rathinaezhil, T Rattay, D Ravichandran, M Reed, S Refsum, D Remoundos, K Rigby, S Robertson, A Robinson, J Robinson, N Roche, PJ Roy, M Runkel, J Rusby, S Saha, Z Saidan, M Salab, M Saleh, F Salem, A Sami, S Samlalsingh, N Sarfraz, R Shah, S Shaheed, Y Sharaiha, G Shetty, R Shotton, T Sircar, E Skene, S Sloan, B Smith, J Smith, L Soldanova, F Soliman, S Soumian, J Stevens, C Steventon, E Stewart-Parker, T Stringfellow, R Sutaria, R Sutton, H Sweetland, B Swiech, S Tadiparthi, H Tafazal, N Taheri, C Tait, M Tan, S Tang, A Tansley, S Tate, S Tayeh, A Taylor, J Taylor, P Thawdar, C Thomas, S Thomas, S Thomson, A Thorne, R Tillett, Z Tolkien, A Tomlins, A Topps, F Tsang, EJ Turner, P Turton, S Udayasankar, F Ugolini, E Vaughan Williams, R Vidya, B Vijaynagar, R Vinayagam, A Volleamere, V Voynov, S Waheed, T Walker, U Walsh, R Warner, R Waters, A Wilkins, K Williams, G Wilson, M Wiltsher, B Wooler, C Wright, M Wright, L Wyld, M Youssef, C Zabkiewicz, C Zammit, B Zeidan, D Zheng
Publikováno v:
Kirwan, C 2019, ' Short-term safety outcomes of mastectomy and immediate implant-based breast reconstruction with and without mesh (iBRA): a multicentre, prospective cohort study. ', Lancet Oncology, vol. 20, no. 2, pp. 254-266 . https://doi.org/10.1016/S1470-2045(18)30781-2
The Lancet. Oncology
Potter, S, Conroy, E, Cutress, R, Williamson, P, Whisker, L, Thrush, S, Skillman, J, Barnes, N, Mylvaganam, S, Teasdale, E, Jain, A, Gardiner, M, Blazeby, J, Holcombe, C 2019, ' Short-term safety outcomes of mastectomy and immediate implant-based breast reconstruction with and without mesh (iBRA) : a multicentre, prospective cohort study ', Lancet Oncology, vol. 20, no. 2, pp. 254-266 . https://doi.org/10.1016/S1470-2045(18)30781-2
The Lancet. Oncology
Potter, S, Conroy, E, Cutress, R, Williamson, P, Whisker, L, Thrush, S, Skillman, J, Barnes, N, Mylvaganam, S, Teasdale, E, Jain, A, Gardiner, M, Blazeby, J, Holcombe, C 2019, ' Short-term safety outcomes of mastectomy and immediate implant-based breast reconstruction with and without mesh (iBRA) : a multicentre, prospective cohort study ', Lancet Oncology, vol. 20, no. 2, pp. 254-266 . https://doi.org/10.1016/S1470-2045(18)30781-2
BACKGROUND: Use of biological or synthetic mesh might improve outcomes of immediate implant-based breast reconstruction-breast reconstruction with implants or expanders at the time of mastectomy-but there is a lack of high-quality evidence to support
Autor:
Daniel A. Nichols, Daniel A. Nin, Sean M. Curtis, Joshua W. Major, Apurba K. Bhattacharjee, Clare E. Gutteridge, Lucia Gerena
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:1048-1051
Investigation of a series of 2,N-bisarylated 2-ethoxyacetamides resulted in the identification of four inhibitors 5, 20, 24, 29 with single-digit micromolar in vitro efficacy against two drug-resistant Plasmodium falciparum strains. These compounds a
Publikováno v:
European Journal of Surgical Oncology. 46:e9