Zobrazeno 1 - 10
of 114
pro vyhledávání: '"E. Grimshaw"'
Autor:
Abbie L. Cawood, R. Meyer, Kate E. Grimshaw, Katy Sorensen, Dionisio Acosta‐Mena, Rebecca J. Stratton
Publikováno v:
Clinical and Translational Allergy, Vol 12, Iss 8, Pp n/a-n/a (2022)
Abstract Background Cow's milk allergy (CMA) is one of the most common food allergies among children. Whilst avoidance of cow's milk protein is the cornerstone of management, further treatment of symptoms including those affecting the gastrointestina
Externí odkaz:
https://doaj.org/article/c3e23accc74340d3bd61f57e982060b1
Autor:
Katy Sorensen, Rosan Meyer, Kate E. Grimshaw, Abbie L. Cawood, Dionisio Acosta‐Mena, Rebecca J. Stratton
Publikováno v:
Immunity, Inflammation and Disease, Vol 10, Iss 3, Pp n/a-n/a (2022)
Abstract Introduction Cow's milk allergy (CMA) is common in infants and children. Clinical presentations may vary, with a range of symptoms affecting the gastrointestinal (GI), skin and respiratory systems. Whilst the primary focus of research to dat
Externí odkaz:
https://doaj.org/article/7e2134b37fd94c72a60c9b7ba7213a47
Autor:
Susanne Müller, Suzanne Ackloo, Cheryl H Arrowsmith, Marcus Bauser, Jeremy L Baryza, Julian Blagg, Jark Böttcher, Chas Bountra, Peter J Brown, Mark E Bunnage, Adrian J Carter, David Damerell, Volker Dötsch, David H Drewry, Aled M Edwards, James Edwards, Jon M Elkins, Christian Fischer, Stephen V Frye, Andreas Gollner, Charles E Grimshaw, Adriaan IJzerman, Thomas Hanke, Ingo V Hartung, Steve Hitchcock, Trevor Howe, Terry V Hughes, Stefan Laufer, Volkhart MJ Li, Spiros Liras, Brian D Marsden, Hisanori Matsui, John Mathias, Ronan C O'Hagan, Dafydd R Owen, Vineet Pande, Daniel Rauh, Saul H Rosenberg, Bryan L Roth, Natalie S Schneider, Cora Scholten, Kumar Singh Saikatendu, Anton Simeonov, Masayuki Takizawa, Chris Tse, Paul R Thompson, Daniel K Treiber, Amélia YI Viana, Carrow I Wells, Timothy M Willson, William J Zuercher, Stefan Knapp, Anke Mueller-Fahrnow
Publikováno v:
eLife, Vol 7 (2018)
Potent, selective and broadly characterized small molecule modulators of protein function (chemical probes) are powerful research reagents. The pharmaceutical industry has generated many high-quality chemical probes and several of these have been mad
Externí odkaz:
https://doaj.org/article/959198e7fd31440495c0d4c7cf3c5c06
Autor:
Paul Tanis, Urmi Banerjee, Ron de Jong, Charles E. Grimshaw, Mark Sabat, Chris Proffitt, Walter Keung, Petro Halkowycz, Kim Peacock, Jacques Ermolieff
Publikováno v:
SLAS Discovery. 26:676-683
Two different signaling pathways lead to the activation of the transcription factor NF-κB, initiating distinct biological responses: The canonical NF-κB pathway activation has been implicated in host immunity and inflammatory responses, whereas the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::461b487527afd747e2f0032556040ba0
https://doi.org/10.1177/2472555220964450
https://doi.org/10.1177/2472555220964450
Autor:
Charles E Grimshaw, Andy Jennings, Ruhi Kamran, Hikaru Ueno, Nobuhiro Nishigaki, Takuo Kosaka, Akiyoshi Tani, Hiroki Sano, Yoshinobu Kinugawa, Emiko Koumura, Lihong Shi, Koji Takeuchi
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0157509 (2016)
Trelagliptin (SYR-472), a novel dipeptidyl peptidase-4 inhibitor, shows sustained efficacy by once-weekly dosing in type 2 diabetes patients. In this study, we characterized in vitro properties of trelagliptin, which exhibited approximately 4- and 12
Externí odkaz:
https://doaj.org/article/c2f5e8f538fd4b978e232dde76104e2e
Autor:
Katy Sorensen, Rosan Meyer, Kate E. Grimshaw, Abbie L. Cawood, Dionisio Acosta‐Mena, Rebecca J. Stratton
Publikováno v:
Immunity, Inflammation and Disease. 10
Cow's milk allergy (CMA) is common in infants and children. Clinical presentations may vary, with a range of symptoms affecting the gastrointestinal (GI), skin and respiratory systems. Whilst the primary focus of research to date has been on the mana
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dd21f7e80534cc4046f6136f6fea284
https://doi.org/10.1002/iid3.572
https://doi.org/10.1002/iid3.572
Autor:
Dalia Barsyte-Lovejoy, Yuji Baba, Peter Brown, Atsushi Kiba, Daisuke Tomita, Douglas R. Cary, Aiping Dong, Hong Zeng, Mihoko Kunitomo, Kazuhide Nakayama, Cheryl H. Arrowsmith, Fengling Li, Matthieu Schapira, Mohammad S. Eram, Charles E. Grimshaw, Yasuhiro Imaeda, Carlo C. dela Seña, Kumar Singh Saikatendu, Hong Wu, Akihiro Ohashi, Michiko Tawada, Renato Ferreira de Freitas, Magdalena M. Szewczyk, Masoud Vedadi
Publikováno v:
Oncotarget
Protein arginine methyltransferase (PRMT) 4 (also known as coactivator-associated arginine methyltransferase 1; CARM1) is involved in a variety of biological processes and is considered as a candidate oncogene owing to its overexpression in several t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35b42f730291d23ed704d496e9284d84
https://doi.org/10.18632/oncotarget.24883
https://doi.org/10.18632/oncotarget.24883
Autor:
Petro Halkowycz, Zacharia Cheruvallath, Mark Sabat, Bumsup Lee, David J. Hosfield, Andrew John Jennings, Haixia Wang, Mingnam Tang, Stephen L. Gwaltney, Yiqin Wu, Charles E. Grimshaw
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:2678-2682
Guided by co-crystal structural information obtained from a different series we were exploring, a scaffold morphing and SBDD approach led to the discovery of the 1,4-disubstituted indazole series as a novel class of GKAs that potently activate GK in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ed0d84b42b1111c1cc3b8ded9c30c17
https://doi.org/10.1016/j.bmcl.2017.04.041
https://doi.org/10.1016/j.bmcl.2017.04.041
Autor:
David H. Drewry, Steve Hitchcock, Volker Dötsch, Ingo Hartung, Brian D. Marsden, Hisanori Matsui, C. Bountra, Carrow I. Wells, Marcus Bauser, Stefan Knapp, Volkhart Mj Li, Amélia Yi Viana, Christian Fischer, Mathias John Paul, Adrian Carter, Spiros Liras, Julian Blagg, Mark Edward Bunnage, Suzanne Ackloo, Adriaan P. IJzerman, Susanne Müller, Stephen V. Frye, Saul H Rosenberg, Natalie S Schneider, Daniel K Treiber, Andreas Gollner, David R. Damerell, Cora Scholten, Bryan L. Roth, Cheryl H. Arrowsmith, Charles E. Grimshaw, Aled M. Edwards, Kumar Singh Saikatendu, Timothy M. Willson, Jeremy L Baryza, Thomas Hanke, Masayuki Takizawa, Peter Brown, Terry V Hughes, James P. Edwards, Daniel Rauh, Trevor Howe, Anke Mueller-Fahrnow, Ronan C. O'Hagan, Chris Tse, Vineet Pande, Anton Simeonov, Paul R. Thompson, Dafydd R. Owen, J.M. Elkins, Jark Böttcher, William J. Zuercher, Stefan Laufer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d718f899c5ce6099584927eb7f1b37e
https://doi.org/10.7554/elife.34311.009
https://doi.org/10.7554/elife.34311.009
Autor:
Julian Blagg, David H. Drewry, Steve Hitchcock, Hisanori Matsui, Carrow I. Wells, Daniel Rauh, Anke Mueller-Fahrnow, Ronan C. O'Hagan, Adriaan P. IJzerman, Kumar Singh Saikatendu, Stefan Laufer, Timothy M. Willson, Paul R. Thompson, Chris Tse, Saul H Rosenberg, C. Bountra, Marcus Bauser, Dafydd R. Owen, Brian D. Marsden, Terry V Hughes, Daniel K Treiber, James P. Edwards, Bryan L. Roth, Cheryl H. Arrowsmith, Suzanne Ackloo, J.M. Elkins, Adrian Carter, Spiros Liras, Stefan Knapp, Christian Fischer, Susanne Müller, Amélia Yi Viana, Mathias John Paul, William J. Zuercher, Masayuki Takizawa, Jeremy L Baryza, Thomas Hanke, Peter Brown, David R. Damerell, Cora Scholten, Stephen V. Frye, Anton Simeonov, Mark Edward Bunnage, Charles E. Grimshaw, Andreas Gollner, Aled M. Edwards, Natalie S Schneider, Trevor Howe, Volker Dötsch, Ingo Hartung, Jark Böttcher, Vineet Pande, Volkhart Mj Li
Publikováno v:
eLife, Vol 7 (2018)
eLife
ELIFE, 7, e34311. ELIFE SCIENCES PUBLICATIONS LTD
eLife
ELIFE, 7, e34311. ELIFE SCIENCES PUBLICATIONS LTD
Potent, selective and broadly characterized small molecule modulators of protein function (chemical probes) are powerful research reagents. The pharmaceutical industry has generated many high-quality chemical probes and several of these have been mad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba91100a44a3d9b67ccf3f2841cb55bf