Zobrazeno 1 - 10
of 910
pro vyhledávání: '"E. Goddard"'
Autor:
Mohammad Ghoreishifar, Amanda J. Chamberlain, Ruidong Xiang, Claire P. Prowse-Wilkins, Thomas J. Lopdell, Mathew D. Littlejohn, Jennie E. Pryce, Michael E. Goddard
Publikováno v:
Genetics Selection Evolution, Vol 56, Iss 1, Pp 1-11 (2024)
Abstract Background Genome sequence variants affecting complex traits (quantitative trait loci, QTL) are enriched in functional regions of the genome, such as those marked by certain histone modifications. These variants are believed to influence gen
Externí odkaz:
https://doaj.org/article/909bbb2cefc147078721ba74bc8405dd
Autor:
Mehrnush Forutan, Bailey N. Engle, Amanda J. Chamberlain, Elizabeth M. Ross, Loan T. Nguyen, Michael J. D’Occhio, Alf Collins Snr, Elise A. Kho, Geoffry Fordyce, Shannon Speight, Michael E. Goddard, Ben J. Hayes
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-12 (2024)
Abstract Most genetic variants associated with fertility in mammals fall in non-coding regions of the genome and it is unclear how these variants affect fertility. Here we use genome-wide association summary statistics for Heifer puberty (pubertal or
Externí odkaz:
https://doaj.org/article/6a62bad138bb4514934e92cd1f173ef4
Autor:
Irene van den Berg, Amanda J. Chamberlain, Iona M. MacLeod, Tuan V. Nguyen, Mike E. Goddard, Ruidong Xiang, Brett Mason, Susanne Meier, Claire V. C. Phyn, Chris R. Burke, Jennie E. Pryce
Publikováno v:
Genetics Selection Evolution, Vol 56, Iss 1, Pp 1-18 (2024)
Abstract Background Female fertility is an important trait in dairy cattle. Identifying putative causal variants associated with fertility may help to improve the accuracy of genomic prediction of fertility. Combining expression data (eQTL) of genes,
Externí odkaz:
https://doaj.org/article/eb916b93e29a4197bc37af791abba3ff
Autor:
Thomas J. Lopdell, Alexander J. Trevarton, Janelle Moody, Claire Prowse-Wilkins, Sarah Knowles, Kathryn Tiplady, Amanda J. Chamberlain, Michael E. Goddard, Richard J. Spelman, Klaus Lehnert, Russell G. Snell, Stephen R. Davis, Mathew D. Littlejohn
Publikováno v:
Genetics Selection Evolution, Vol 56, Iss 1, Pp 1-18 (2024)
Abstract Background Bovine lactoferrin (Lf) is an iron absorbing whey protein with antibacterial, antiviral, and antifungal activity. Lactoferrin is economically valuable and has an extremely variable concentration in milk, partly driven by environme
Externí odkaz:
https://doaj.org/article/8080a82b88cf4f85b058bde3a2e3767d
Autor:
E. Goddard, Y. Probst
Publikováno v:
Journal of Nutrition & Intermediary Metabolism, Vol 1, Iss C, p 40 (2014)
Externí odkaz:
https://doaj.org/article/6ebaa230518646c08f9829ede96734e5
Autor:
Claire P. Prowse-Wilkins, Jianghui Wang, Josie B. Garner, Michael E. Goddard, Amanda J. Chamberlain
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract Allele specific expression (ASE) is widespread in many species including cows. Therefore, regulatory regions which control gene expression should show cis-regulatory variation which mirrors this differential expression within the animal. ChI
Externí odkaz:
https://doaj.org/article/06abafbb7b274c2ca944c8d89afea96f
Autor:
Ruidong Xiang, Lingzhao Fang, Shuli Liu, Iona M. Macleod, Zhiqian Liu, Edmond J. Breen, Yahui Gao, George E. Liu, Albert Tenesa, Brett A. Mason, Amanda J. Chamberlain, Naomi R. Wray, Michael E. Goddard
Publikováno v:
Cell Genomics, Vol 3, Iss 10, Pp 100385- (2023)
Summary: Many quantitative trait loci (QTLs) are in non-coding regions. Therefore, QTLs are assumed to affect gene regulation. Gene expression and RNA splicing are primary steps of transcription, so DNA variants changing gene expression (eVariants) o
Externí odkaz:
https://doaj.org/article/97272e77d4a5469f8c556d16c5b5034e
Autor:
Tuan V. Nguyen, Christy J. Vander Jagt, Jianghui Wang, Hans D. Daetwyler, Ruidong Xiang, Michael E. Goddard, Loan T. Nguyen, Elizabeth M. Ross, Ben J. Hayes, Amanda J. Chamberlain, Iona M. MacLeod
Publikováno v:
Genetics Selection Evolution, Vol 55, Iss 1, Pp 1-15 (2023)
Abstract Studies have demonstrated that structural variants (SV) play a substantial role in the evolution of species and have an impact on Mendelian traits in the genome. However, unlike small variants (
Externí odkaz:
https://doaj.org/article/659b18ddcf7241ca859ede196b0ba0f0
Autor:
Claire P. Prowse-Wilkins, Thomas J. Lopdell, Ruidong Xiang, Christy J. Vander Jagt, Mathew D. Littlejohn, Amanda J. Chamberlain, Michael E. Goddard
Publikováno v:
BMC Genomics, Vol 23, Iss 1, Pp 1-19 (2022)
Abstract Background Causal variants for complex traits, such as eQTL are often found in non-coding regions of the genome, where they are hypothesised to influence phenotypes by regulating gene expression. Many regulatory regions are marked by histone
Externí odkaz:
https://doaj.org/article/bc8d9d89f6eb439bb8e78fb640312239
Autor:
Sunduimijid Bolormaa, Iona M. MacLeod, Majid Khansefid, Leah C. Marett, William J. Wales, Filippo Miglior, Christine F. Baes, Flavio S. Schenkel, Erin E. Connor, Coralia I. V. Manzanilla-Pech, Paul Stothard, Emily Herman, Gert J. Nieuwhof, Michael E. Goddard, Jennie E. Pryce
Publikováno v:
Genetics Selection Evolution, Vol 54, Iss 1, Pp 1-17 (2022)
Abstract Background Sharing individual phenotype and genotype data between countries is complex and fraught with potential errors, while sharing summary statistics of genome-wide association studies (GWAS) is relatively straightforward, and thus woul
Externí odkaz:
https://doaj.org/article/1fd8f15c792044cc9755c1186e0c3c46