Výsledky vyhledávání

Morphological alterations induced by sodium valproate on somites and spinal nerves in rat embryos

Autor: E, Menegola, M L, Broccia, M, Prati, E, Giavini

Publikováno v: Teratology. 59(2)

The antiepileptic drug valproic acid is a well-known teratogenic agent; its main target organ is the neural tube, though skeletal malformations have also been described. In our recent work, respecifications of vertebrae were described in rat fetuses

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6d75e89949f21720cb17fb964c625856
https://pubmed.ncbi.nlm.nih.gov/10069441

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Akademický článek

Diverting organic waste from landfills via insect biomanufacturing using engineered black soldier flies (Hermetia illucens).

Autor: Tepper, Kate^1,2,3 (AUTHOR), Edwards, Owain³ (AUTHOR), Sunna, Anwar^4,5 (AUTHOR), Paulsen, Ian T.^2,4,5 (AUTHOR), Maselko, Maciej^1,2,3,5 (AUTHOR) maciej.maselko@mq.edu.au

Publikováno v: Communications Biology. 7/24/2024, Vol. 7 Issue 1, p1-14. 14p.

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Teratogenic effects of sodium valproate in mice and rats at midgestation and at term

Autor: E, Menegola, M L, Broccia, H, Nau, M, Prati, R, Ricolfi, E, Giavini

Publikováno v: Teratogenesis, carcinogenesis, and mutagenesis. 16(2)

This experiment was carried out with the aims of comparing the embryotoxic potential of valproic acid (VPA) in rats and mice, better defining the malformation pattern in these species, and comparing the embryotoxic effects detectable in mid-pregnancy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dac27bc9f1f17ff8bd9879acf5f9e013
https://pubmed.ncbi.nlm.nih.gov/8875740

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Alternatives to in vivo tests for teratologic screening

Autor: M, Prati, E, Giavini, E, Menegola

Publikováno v: Annali dell'Istituto superiore di sanita. 29(1)

During the last decade there has been a tremendous increase in publications describing methods for in vitro toxicological research and emphasizing their advantages, suitability and necessity, rather than the classical in vivo studies. In this review

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::325fe40bf2b4218635a002a15750b838
https://pubmed.ncbi.nlm.nih.gov/8129271

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Diabetes in pregnancy: experimental aspects

Autor: E, Giavini

Publikováno v: Annali dell'Istituto superiore di sanita. 29(1)

Substantial literature indicates that diabetes in pregnant rats and mice induces embryo lethality, growth retardation, and a variable incidence of birth defects. All these embryopathic effects appear to be mediated by several factors, e.g. genetic di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2a28d801fdb464b49d91def135eb1ce2
https://pubmed.ncbi.nlm.nih.gov/8129268

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Damage to the crystalline lens in infants of diabetic mothers: a pathology so far neglected?

Autor: E. Giavini, G.D. Roversi

Publikováno v: Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde. 204(4)

Congenital cataract occurs in 90-95% of diabetic rat fetuses. The pathogenetic mechanism is triggered by fetal hyperglycemia and presents the following steps: (1) a high glucose concentration in the lens; (2) reduction of glucose to sorbitol by aldos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbec1b6811101cbc1da10ebfd9fc23bf
https://pubmed.ncbi.nlm.nih.gov/1513548

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