Zobrazeno 1 - 10 of 34 pro vyhledávání: '"E. Gentles"'
1
Akademický článek
Attenuated Influenza Virions Expressing the SARS-CoV-2 Receptor-Binding Domain Induce Neutralizing Antibodies in Mice
Autor: Andrea N. Loes, Lauren E. Gentles, Allison J. Greaney, Katharine H. D. Crawford, Jesse D. Bloom
Publikováno v: Viruses, Vol 12, Iss 9, p 987 (2020)
An effective vaccine is essential for controlling the spread of the SARS-CoV-2 virus. Here, we describe an influenza virus-based vaccine for SARS-CoV-2. We incorporated a membrane-anchored form of the SARS-CoV-2 spike receptor binding domain (RBD) in
Externí odkaz: https://doaj.org/article/a81ba677af6b4bf286a8a79e248c7f43
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2
Akademický článek
Antibody Neutralization of an Influenza Virus that Uses Neuraminidase for Receptor Binding
Autor: Lauren E. Gentles, Hongquan Wan, Maryna C. Eichelberger, Jesse D. Bloom
Publikováno v: Viruses, Vol 12, Iss 6, p 597 (2020)
Influenza virus infection elicits antibodies against the receptor-binding protein hemagglutinin (HA) and the receptor-cleaving protein neuraminidase (NA). Because HA is essential for viral entry, antibodies targeting HA often potently neutralize the
Externí odkaz: https://doaj.org/article/4ce92a5e6e5a45a09b6697954cb75d22
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4
Akademický článek
Influenza A virus hemagglutinin glycosylation compensates for antibody escape fitness costs.
Autor: Ivan Kosik, William L Ince, Lauren E Gentles, Andrew J Oler, Martina Kosikova, Matthew Angel, Javier G Magadán, Hang Xie, Christopher B Brooke, Jonathan W Yewdell
Publikováno v: PLoS Pathogens, Vol 14, Iss 1, p e1006796 (2018)
Rapid antigenic evolution enables the persistence of seasonal influenza A and B viruses in human populations despite widespread herd immunity. Understanding viral mechanisms that enable antigenic evolution is critical for designing durable vaccines a
Externí odkaz: https://doaj.org/article/a8d6e151814b4d49b5ff844bb40bacbc
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5
Dynamics of infection-elicited SARS-CoV-2 antibodies in children over time
Autor: Lauren E. Gentles, Leanne Kehoe, Katharine H.D. Crawford, Kirsten Lacombe, Jane Dickerson, Caitlin Wolf, Joanna Yuan, Susanna Schuler, John T. Watson, Sankan Nyanseor, Melissa Briggs-Hagen, Sharon Saydah, Claire M. Midgley, Kimberly Pringle, Helen Chu, Jesse D. Bloom, Janet A. Englund
Publikováno v: medRxiv
article-version (status) pre
article-version (number) 1
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection elicits an antibody response that targets several viral proteins including spike (S) and nucleocapsid (N); S is the major target of neutralizing antibodies. Here, we assess levels
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0ceb63962fd4deb253682acea45bd83
http://europepmc.org/articles/PMC8811949
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6
LB9. Longitudinal antibody dynamics in children infected with SARS-CoV-2 through 6 months post-infection
Autor: Lauren E Gentles, Leanne P Kehoe, Katharine D Crawford, Kirsten Lacombe, Jane Dickerson, Joanna H Yuan, Susanna L Schuler, Sankan Nyanseor, Sharon Saydah, Claire Midgley, Kimberly Pringle, Jesse Bloom, Janet A Englund
Publikováno v: Open Forum Infectious Diseases
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection elicits antibodies (Abs) that bind several viral proteins such as the spike entry protein and the abundant nucleocapsid (N) protein. We examined convalescent sera colle
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deeebff6cd5a4d0908e73ccf1c91d365
http://europepmc.org/articles/PMC8644934
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7
The SARS-CoV-2 mRNA-1273 vaccine elicits more RBD-focused neutralization, but with broader antibody binding within the RBD
Autor: Jesse D. Bloom, Keara D. Malone, Lauren E. Gentles, Allison J. Greaney, Katharine H.D. Crawford, Tyler N. Starr, Andrea N. Loes, Helen Y. Chu
Publikováno v: Sci Transl Med
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with mutations in key antibody epitopes has raised concerns that antigenic evolution could erode adaptive immunity elicited by prior infection or vaccination. The
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55635b2cd4e32cc7aea626429871d8c3
https://pubmed.ncbi.nlm.nih.gov/34103407
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8
Antibodies elicited by mRNA-1273 vaccination bind more broadly to the receptor binding domain than do those from SARS-CoV-2 infection
Autor: Keara D. Malone, Helen Y. Chu, Katharine H.D. Crawford, Jesse D. Bloom, Allison J. Greaney, Andrea N. Loes, Lauren E. Gentles, Tyler N. Starr
Publikováno v: bioRxiv
article-version (status) pre
article-version (number) 1
The emergence of SARS-CoV-2 variants with mutations in key antibody epitopes has raised concerns that antigenic evolution will erode immunity. The susceptibility of immunity to viral evolution is shaped in part by the breadth of epitopes targeted. He
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5df39cb37037cb1f336c4b125793800
https://pubmed.ncbi.nlm.nih.gov/33880474
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10
Attenuated Influenza Virions Expressing the SARS-CoV-2 Receptor-Binding Domain Induce Neutralizing Antibodies in Mice
Autor: Allison J. Greaney, Jesse D. Bloom, Katharine H.D. Crawford, Lauren E. Gentles, Andrea N. Loes
Publikováno v: Viruses, Vol 12, Iss 987, p 987 (2020)
Viruses
Volume 12
Issue 9
bioRxiv
article-version (status) pre
article-version (number) 1
An effective vaccine is essential for controlling the spread of the SARS-CoV-2 virus. Here, we describe an influenza virus-based vaccine for SARS-CoV-2. We incorporated a membrane-anchored form of the SARS-CoV-2 spike receptor binding domain (RBD) in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71e14150c20dd016cc94f715f7aa4cbb
https://www.mdpi.com/1999-4915/12/9/987
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