Zobrazeno 1 - 10
of 1 185
pro vyhledávání: '"E. Gardiner"'
Autor:
J. T. Cullen, P. G. Lawlor, F. Viard, A. Lourenco, L. G. Gómez-Mascaraque, J. V. O’Doherty, P. Cormican, G. E. Gardiner
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Poor feeding system hygiene may contribute to uncontrolled spontaneous fermentation in liquid pig feed and its associated undesirable effects. This study aimed to determine the effects of an intensive sanitisation programme in a grow-finishe
Externí odkaz:
https://doaj.org/article/6738f3adb0be4f02b52a19becbedb22f
Autor:
Jonathan Cubitt, Mari Davies, Ross Riseley, Gabrielle Evans, Sian E. Gardiner, Benson M. Kariuki, Simon E. Ward, Emyr Lloyd-Evans, Helen Waller-Evans, D. Heulyn Jones
Publikováno v:
Molecules, Vol 29, Iss 21, p 5143 (2024)
Following a High-Throughput Screening campaign to discover inhibitors of acid ceramidase, we report the novel and extremely potent covalent inhibitor, 1. Following resynthesis and stability monitoring, we discovered that 1 is chemically unstable and
Externí odkaz:
https://doaj.org/article/6b64ce8ede1847c1b1f1357524277e8d
Autor:
Yangyang Ding, Xiang Gui, Xiang Chu, Yueyue Sun, Sixuan Zhang, Huan Tong, Wen Ju, Yue Li, Zengtian Sun, Mengdi Xu, Zhenyu Li, Robert K. Andrews, Elizabeth E. Gardiner, Lingyu Zeng, Kailin Xu, Jianlin Qiao
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Human MutT Homolog 1 (MTH1) is a nucleotide pool sanitization enzyme that hydrolyzes oxidized nucleotides to prevent their mis-incorporation into DNA under oxidative stress. Expression and functional roles of MTH1 in platelets are not known.
Externí odkaz:
https://doaj.org/article/c6a5b3d2352342c1b144fc7df9711183
Autor:
Ruth Rattigan, Peadar G. Lawlor, Paul Cormican, Daniel Crespo-Piazuelo, James Cullen, John P. Phelan, Samir Ranjitkar, Fiona Crispie, Gillian E. Gardiner
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-18 (2023)
Abstract This study examined the effects of maternal and/or post-weaning Bacillus altitudinis supplementation on the microbiota in sow colostrum and faeces, and offspring digesta and faeces. Sows (n = 12/group) were assigned to: (1) standard diet (CO
Externí odkaz:
https://doaj.org/article/03eb3f19efc14f3e9d4127e2348891af
Autor:
Christine Shu Mei Lee, Amandeep Kaur, Samantha J. Montague, Sarah M. Hicks, Robert K. Andrews, Elizabeth E. Gardiner
Publikováno v:
Platelets, Vol 34, Iss 1 (2023)
AbstractPlatelet-specific collagen receptor glycoprotein (GP)VI is stable on the surface of circulating platelets but undergoes ectodomain cleavage on activated platelets. Activation-dependent GPVI metalloproteolysis is primarily mediated by A Disint
Externí odkaz:
https://doaj.org/article/77429db278d34f55a26c65f85a851f2d
Publikováno v:
Platelets, Vol 34, Iss 1 (2023)
Externí odkaz:
https://doaj.org/article/fbcec1be27024b6d9c2eafe2c56e5d62
Publikováno v:
Platelets, Vol 33, Iss 4, Pp 503-511 (2022)
Primary thrombotic microangiopathies (TMAs) are observed in thrombotic thrombocytopenic purpura (TTP) and hemolytic uremic syndrome (HUS), while secondary TMAs have a wide range of etiologies. Early diagnosis and treatment of TMA are critical for pat
Externí odkaz:
https://doaj.org/article/f73c4bb625e54cbf845a10ae4c4fd44c
Autor:
Chloe R. Koulouris, Sian E. Gardiner, Tessa K. Harris, Karen T. Elvers, S. Mark Roe, Jason A. Gillespie, Simon E. Ward, Olivera Grubisha, Robert A. Nicholls, John R. Atack, Benjamin D. Bax
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-15 (2022)
The catalytic mechanisms of human serine racemase reveal a ligandable pocket near Tyr121 that could be targeted for the development of novel inhibitors.
Externí odkaz:
https://doaj.org/article/08d2829bfb8f4f288b7fb5de272a4d80
Publikováno v:
eJHaem, Vol 3, Iss 1, Pp 80-85 (2022)
Abstract Platelet transfusions are not always available for bleeding in severe thrombocytopenia, as storage outside of major centers is limited by their short shelf‐life. Data are lacking to support alternative available blood products; however, ad
Externí odkaz:
https://doaj.org/article/296dada9878f487495f714d2b825c4fa
Autor:
Kevin Jerez-Bogota, Martin Jensen, Ole Højberg, Paul Cormican, Peadar G. Lawlor, Gillian E. Gardiner, Nuria Canibe
Publikováno v:
Frontiers in Veterinary Science, Vol 10 (2023)
Antibiotics and zinc oxide restrictions encourage the search for alternatives to combat intestinal pathogens, including enterotoxigenic Escherichia coli (ETEC), a major cause of postweaning diarrhea (PWD) in pigs. PWD causes important economic losses
Externí odkaz:
https://doaj.org/article/3a98c551f53949b0bbdcfbfc9b35590d