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Akademický článek

Typhoid toxin sorting and exocytic transport from Salmonella Typhi-infected cells

Autor: Shu-Jung Chang, Yu-Ting Hsu, Yun Chen, Yen-Yi Lin, Maria Lara-Tejero, Jorge E Galan

Publikováno v: eLife, Vol 11 (2022)

Typhoid toxin is an essential virulence factor for Salmonella Typhi, the cause of typhoid fever in humans. This toxin has an unusual biology in that it is produced by Salmonella Typhi only when located within host cells. Once synthesized, the toxin i

Externí odkaz: https://doaj.org/article/fc249916c90d4ba29054b3d3d842f1d0

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Akademický článek

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Akademický článek

A protein secreted by the Salmonella type III secretion system controls needle filament assembly

Autor: Junya Kato, Supratim Dey, Jose E Soto, Carmen Butan, Mason C Wilkinson, Roberto N De Guzman, Jorge E Galan

Publikováno v: eLife, Vol 7 (2018)

Type III protein secretion systems (T3SS) are encoded by several pathogenic or symbiotic bacteria. The central component of this nanomachine is the needle complex. Here we show in a Salmonella Typhimurium T3SS that assembly of the needle filament of

Externí odkaz: https://doaj.org/article/0b4e2ae158644ceb800dce215a709b3c

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Akademický článek

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Author response: Typhoid toxin sorting and exocytic transport from Salmonella Typhi-infected cells

Autor: Shu-Jung Chang, Yu-Ting Hsu, Yun Chen, Yen-Yi Lin, Maria Lara-Tejero, Jorge E Galan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0e8e7e178ef3d4f2fbb8761c87466ae5
https://doi.org/10.7554/elife.78561.sa2

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EXPERIMENTAL EVALUATION OF TOXICOMETRIC INDICATORS AND ANALGESIC ACTIVITY OF KAPPA-OPIOID RECEPTOR AGONISTS

Autor: S. V. Chepur, S. E. Galan, M. S. Vakhviayanen, A. N. Semenov, R. N. Khromov

Publikováno v: Toxicological Review. :27-33

Data on the biological activity of kappa-opioid receptor agonists - derivatives of three groups of compounds: 1,2-cyclohexylamine, 1,2,3,4-piperidine, 1,2,4-piperazine are presented. On the examples of 1,2-cyclohexylamine and 1,2,4-piperazine derivat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4f2c719dce201068c0ad324e9e57de16
https://doi.org/10.36946/0869-7922-2020-4-27-33

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Author response for 'Effect of short‐term use of dapagliflozin on impaired awareness of hypoglycaemia in people with type 1 diabetes'

Autor: null Lian A. Meijel, null Cees J. Tack, null Bastiaan E. Galan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6e0a7660d9c152435addaf9741dff553
https://doi.org/10.1111/dom.14505/v3/response1

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Overlapping genetic architecture between Parkinson disease and melanoma

Autor: Dube, Umber Ibanez, Laura Budde, John P. Benitez, Bruno A. and Davis, Albert A. Harari, Oscar Iles, Mark M. Law, Matthew H. Brown, Kevin M. Agee, Michelle Alipanahi, Babak and Auton, Adam Bell, Robert K. Bryc, Katarzyna Elson, Sarah L. Fontanillas, Pierre Furlotte, Nicholas A. Hinds, David A. and Huber, Karen E. Kleinman, Aaron Litterman, Nadia K. and McCreight, Jennifer C. McIntyre, Matthew H. Mountain, Joanna L. and Noblin, Elizabeth S. Northover, Carrie A. M. Pitts, Steven J. Sathirapongsasuti, J. Fah Sazonova, Olga V. Shelton, Janie F. Shringarpure, Suyash Tian, Chao Tung, Joyce Y. and Vacic, Vladimir Wilson, Catherine H. Law, M. H. Law, M. H. and Bishop, D. T. Lee, J. E. Brossard, M. Martin, N. G. and Moses, E. K. Song, F. Barrett, J. H. Kumar, R. Easton, D. F. Pharoah, P. D. Swerdlow, A. J. Kypreou, K. P. and Taylor, J. C. Harland, M. Randerson-Moor, J. Akslen, L. A. and Andresen, P. A. Avril, M. F. Azizi, E. Scarra, G. B. and Brown, K. M. Debniak, T. Duffy, D. L. Elder, D. E. Fang, S. Friedman, E. Galan, P. Ghiorzo, P. Gillanders, E. M. and Goldstein, A. M. Gruis, N. A. Hansson, J. Helsing, P. and Hocevar, M. Hoiom, V. Ingvar, C. Kanetsky, P. A. and Chen, W. V. Landi, M. T. Lang, J. Lathrop, G. M. and Lubinski, J. Mackie, R. M. Mann, G. J. Molven, A. and Montgomery, G. W. Novakovic, S. Olsson, H. Puig, S. and Puig-Butille, J. A. Wu, W. Qureshi, A. A. Radford-Smith, G. L. Van der Stoep, N. Van Doorn, R. Whiteman, D. C. and Craig, J. E. Schadendorf, E. Simms, L. A. Burdon, K. P. and Nyholt, D. R. Pooley, K. A. Orr, N. Stratigos, A. J. and Cust, A. E. Ward, S. V. Hayward, N. K. Han, J. Schulze, H. J. Dunning, A. M. Bishop, J. A. Demenais, F. Amos, C. I. MacGregor, S. Iles, M. M. Cruchaga, Carlos 23andMe Research Team Melanoma Meta Analysis Consortium

Epidemiologic studies have reported inconsistent results regarding an association between Parkinson disease (PD) and cutaneous melanoma (melanoma). Identifying shared genetic architecture between these diseases can support epidemiologic findings and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2127::1905f5887039213174d4ef010ad945b1
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3189403

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Prospects of a Search for Kappa-Opioid Receptor Agonists with Analgesic Activity (Review)

Autor: L. A. Pavlova, S. E. Galan, N. I. Zaitseva

Publikováno v: Pharmaceutical Chemistry Journal. 51:843-851

Current approaches to the search for new kappa-opioid receptor (κ-OR) agonists with potential analgesic activity are reviewed. Agents with peripheral activity and biased agonists are most promising for development. Signal events initiated by κ-OR a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::67fef2bf342d1d8d67fbb83c041aae60
https://doi.org/10.1007/s11094-018-1703-y

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