Zobrazeno 1 - 10
of 15
pro vyhledávání: '"E. G. Routledge"'
Publikováno v:
The Journal of general virology. 87(Pt 5)
Monoclonal antibodies (mAbs) to conserved epitopes on the G glycoprotein of human respiratory syncytial virus (HRSV) subgroup A fail to neutralize the virus in cell culture in the absence of complement, but are protective in rodent models of infectio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a15b5755124bc76f0a0ce0a97e3f942
https://pubmed.ncbi.nlm.nih.gov/16603529
https://pubmed.ncbi.nlm.nih.gov/16603529
Autor:
E. G. Routledge, Søren Nielsen
Publikováno v:
Blood. 100(12)
We have previously shown that bivalent human γ1 CD3 monoclonal antibody (mAb) is ineffective at mediating lysis of human T cells with human complement. In this paper we have used genetic engineering and sulfur chemistry to prepare 2 types of human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c2cb084422b988e954acced6ae6106d
https://pubmed.ncbi.nlm.nih.gov/12393711
https://pubmed.ncbi.nlm.nih.gov/12393711
Publikováno v:
Gene therapy. 6(4)
Using genetic engineering techniques, two strategies for changing the receptor-binding specificity of the influenza A virus haemagglutinin (HA) protein whilst preserving its membrane fusion function, have been explored. The aim was to investigate whe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97af3ea1a2d061d6a18bc5356877afd4
https://pubmed.ncbi.nlm.nih.gov/10476231
https://pubmed.ncbi.nlm.nih.gov/10476231
Publikováno v:
Transplantation. 60(8)
The factors affecting the immunogenicity of a humanized gamma 1 CD3 monoclonal antibody (mAb) were investigated in transgenic mice that express the human CD3 antigen epsilon polypeptide (the mAb target antigen). Two derivatives of the mAb were employ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::061561f4f48446d2f5b0ae1a1d0f2161
https://pubmed.ncbi.nlm.nih.gov/7482746
https://pubmed.ncbi.nlm.nih.gov/7482746
Publikováno v:
Therapeutic immunology. 1(5)
Antibody-mediated lysis of cells involves a complex interaction between the cell, the target antigen, the antibody and host effector mechanisms. One such mechanism, complement-mediated cell lysis, requires the interaction of C1q with the antibody hea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5d65615b9fc53e35a1d571dbcda547a5
https://pubmed.ncbi.nlm.nih.gov/7584499
https://pubmed.ncbi.nlm.nih.gov/7584499
Autor:
Geoffrey L. Toms, P. D. Milner, M. S. C. Webb, A Swarbrick, E. G. Routledge, Anthony D Milner, R. Scott, C. E. Taylor, G M Stokes
Publikováno v:
Archives of Disease in Childhood. 64:1661-1665
Serum antibodies to the fusion (F) and large glycoprotein (G) of respiratory syncytial virus in the serum of 57 infected infants were measured by enzyme linked immunosorbent assay (ELISA). Most serum samples taken at the time of admission to hospital
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c78effe04b6f50039cd52fa89cf5c55a
https://doi.org/10.1136/adc.64.12.1661
https://doi.org/10.1136/adc.64.12.1661
Publikováno v:
Journal of General Virology. 67:2059-2064
Summary Glycoproteins synthesized in both human (HeLa and HEp-2) and simian (Vero and BS-C-1) cell lines following infection with two different strains of respiratory syncytial virus (A2 and Long) were analysed by SDS-PAGE following immunoprecipitati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6938bac5dc6cace82d19b7ac3fde365
https://doi.org/10.1099/0022-1317-67-9-2059
https://doi.org/10.1099/0022-1317-67-9-2059
Publikováno v:
Journal of General Virology. 68:1217-1222
Immunofluorescent staining of unfixed respiratory syncytial virus-infected HeLa cells with monoclonal antibodies (MAbs) demonstrated that the 22K protein is expressed on the cell membrane along with the fusion (F) protein and large glycoprotein (G).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91a5ef2fe0660fd0866168d0366084a5
https://doi.org/10.1099/0022-1317-68-4-1217
https://doi.org/10.1099/0022-1317-68-4-1217
Publikováno v:
Journal of General Virology. 70:2197-2200
We have prepared monoclonal antibodies to the capsid protein of feline calicivirus (FCV). These antibodies are directed against two close but distinct epitopes, only one of which is involved in virus neutralization. We have used these antibodies and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::923cfd4e5534a7516583ab9fedd40179
https://doi.org/10.1099/0022-1317-70-8-2197
https://doi.org/10.1099/0022-1317-70-8-2197
Publikováno v:
Journal of General Virology. 68:1209-1215
Respiratory syncytial (RS) virus-infected HeLa, HEp-2, Vero and BS-C-1 cell lysates were electrophoresed on SDS-polyacrylamide gels under reducing conditions and analysed by Western blotting and immunoperoxidase using monoclonal antibodies specific f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::166bed961c5f0c5e83ab029953808202
https://doi.org/10.1099/0022-1317-68-4-1209
https://doi.org/10.1099/0022-1317-68-4-1209