Zobrazeno 1 - 10
of 64
pro vyhledávání: '"E. G. McGeer"'
Autor:
P. L. McGeer, E. G. McGeer
Publikováno v:
Muscle & Nerve. 26:459-470
Neuroinflammation is a characteristic of pathologically affected tissue in several neurodegenerative disorders. These changes can be observed in the brainstem and spinal cord of amyotrophic lateral sclerosis (ALS) cases and in mouse models of the dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfcce94c351172f5fad97c7724397ef5
https://doi.org/10.1002/mus.10191
https://doi.org/10.1002/mus.10191
The peripheral benzodiazepine receptor ligand PK 11195 inhibits arthritis in the MRL-lpr mouse model
Publikováno v:
Rheumatology. 38:1068-1073
Objective. Mice of the MRL-lpr strain develop a severe autoimmune arthritic condition when primed with complete Freund's adjuvant. The pathology is similar to that seen in human rheumatoid arthritis. We investigated whether PK 11195, a powerful ligan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::279bcc60a83f60c2c1beaa02ef5dd902
https://doi.org/10.1093/rheumatology/38.11.1068
https://doi.org/10.1093/rheumatology/38.11.1068
Autor:
E G, McGeer, P L, McGeer
Publikováno v:
Molecular interventions. 1(1)
Over the past fifteen years, evidence has been accumulating that there is a chronic inflammatory reaction in areas of the brain affected by Alzheimer's disease. Chronic inflammation, which arises in reaction to an underlying pathology, represents a t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c7e26fc6e042cf7e62f4afe0d31714f7
https://pubmed.ncbi.nlm.nih.gov/14993335
https://pubmed.ncbi.nlm.nih.gov/14993335
Publikováno v:
Advances in neurology. 86
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0497939d9561af401e0a851430e4e022
https://pubmed.ncbi.nlm.nih.gov/11554012
https://pubmed.ncbi.nlm.nih.gov/11554012
Publikováno v:
Journal of neural transmission. Supplementum. 59
It is now generally accepted that the lesions of Alzheimer disease (AD) are associated with a host of inflammatory molecules, including complement proteins, as well as with many activated microglia. Most inflammatory components are synthesized by bra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d7e6674db506e75774969f17e9d4fbe6
https://pubmed.ncbi.nlm.nih.gov/10961418
https://pubmed.ncbi.nlm.nih.gov/10961418
Publikováno v:
Synapse (New York, N.Y.). 37(3)
The plasma membrane dopamine transporter is located on presynaptic nerve terminals and is responsible for the termination of dopaminergic neurotransmission via dopamine reuptake. The dopamine transporter may also contribute to the pathogenesis of Par
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::18eb95bea4fea5e83d221b2c6c4fd9e8
https://pubmed.ncbi.nlm.nih.gov/10881039
https://pubmed.ncbi.nlm.nih.gov/10881039
Autor:
E G, McGeer, P L, McGeer
Publikováno v:
Current pharmaceutical design. 5(10)
Immunohistochemical studies suggested the existence of a chronic inflammatory condition in affected regions of the brain in Alzheimer disease (AD). Since inflammation can be damaging to host tissue, it was hypothesized that antiinflammatory drugs mig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8aebbbbb32f37f043372a949f3ef8109
https://pubmed.ncbi.nlm.nih.gov/10526088
https://pubmed.ncbi.nlm.nih.gov/10526088
Autor:
Thomas J. Ruth, James E. Holden, Salma Jivan, Grace L.-Y. Chan, C. English, Onofre T. DeJesus, E. G. McGeer, Doris J. Doudet
Publikováno v:
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 19(3)
The effectiveness of 6-[18F]fluoro-L- m-tyrosine (6FMT) to evaluate dopamine presynaptic integrity was compared to that of 6-[18F]fluoro-L-dopa (6FDOPA) in vivo by positron emission tomography (PET). Six normal and six 1-methyl-4-phenyl-1,2,3,6-tetra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbfe75aa7d04dae264a837e0e1e2a3f7
https://pubmed.ncbi.nlm.nih.gov/10078880
https://pubmed.ncbi.nlm.nih.gov/10078880
Autor:
P L, McGeer, E G, McGeer
Publikováno v:
Journal of neural transmission. Supplementum. 54
Lesions in such chronic neurodegenerative disorders as Alzheimer disease, Parkinson disease, the parkinsonism dementia complex of Guam and amyotrophic lateral sclerosis have associated with them a variety of proteins known to be involved in inflammat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::90e47f8a8d11262b24a220e72b748a0c
https://pubmed.ncbi.nlm.nih.gov/9850924
https://pubmed.ncbi.nlm.nih.gov/9850924
Autor:
P L, McGeer, E G, McGeer
Publikováno v:
Alzheimer disease and associated disorders. 12
A variety of proteins known to be involved in inflammatory processes are associated with lesions in chronic neurodegenerative disorders such as Alzheimer disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS). This is particu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9cd6dbc940d35c6e3cec35916d99a1c1
https://pubmed.ncbi.nlm.nih.gov/9769023
https://pubmed.ncbi.nlm.nih.gov/9769023