Zobrazeno 1 - 10
of 17
pro vyhledávání: '"E. Fiona Houston"'
Autor:
M. Khalid F. Salamat, Paula Stewart, Helen Brown, Kyle B. C. Tan, Allister Smith, Christopher de Wolf, A. Richard Alejo Blanco, Marc Turner, Jean C. Manson, Sandra McCutcheon, E. Fiona Houston
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Infectious prion diseases have very long incubation periods, and the role that subclinical infections play in transmission, persistence and re-emergence of these diseases is unclear. In this study, we used a well-established model of vCJD (s
Externí odkaz:
https://doaj.org/article/a62cc34c99d64e709a8e006883675474
Autor:
Charlotte M. Thomas, M. Khalid F. Salamat, Christopher de Wolf, Sandra McCutcheon, A. Richard Alejo Blanco, Jean C. Manson, Nora Hunter, E. Fiona Houston
Publikováno v:
PLoS ONE, Vol 18, Iss 11 (2023)
Externí odkaz:
https://doaj.org/article/62fba07bd2f84848922940b4e4e8961e
Autor:
Angela Chong, James D. Foster, Wilfred Goldmann, Lorenzo Gonzalez, Martin Jeffrey, Matthew J. O’Connor, Keith Bishop, Ben C. Maddison, E. Fiona Houston, Kevin C. Gough, Nora Hunter
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract To understand the possible role of mixed-prion infections in disease presentation, the current study reports the co-infection of sheep with bovine spongiform encephalopathy (BSE) and scrapie. The bovine BSE agent was inoculated subcutaneousl
Externí odkaz:
https://doaj.org/article/8389f00c95af4eeab062820d78120c76
Autor:
M Khalid F, Salamat, Paula, Stewart, Helen, Brown, Kyle B C, Tan, Allister, Smith, Christopher, de Wolf, A Richard, Alejo Blanco, Marc, Turner, Jean C, Manson, Sandra, McCutcheon, E Fiona, Houston
Publikováno v:
Salamat, K, Stewart, P, Brown, H, Tan, K, Smith, A, De Wolf, C, Alejo-Blanco, R, Turner, M L, Manson, J C, McCutcheon, S & Houston, F 2022, ' Subclinical infection occurs frequently following low dose exposure to prions by blood transfusion ', Scientific Reports, vol. 12, no. 1, 10923, pp. 1-11 . https://doi.org/10.1038/s41598-022-15105-w
Infectious prion diseases have very long incubation periods, and the role that subclinical infections play in transmission, persistence and re-emergence of these diseases is unclear. In this study, we used a well-established model of vCJD (sheep expe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::562e375682d521711c37a763b2dc0cea
https://doi.org/10.21203/rs.3.rs-1513594/v1
https://doi.org/10.21203/rs.3.rs-1513594/v1
Publikováno v:
Sordo Sordo, L, Martini, A C, Houston, F, Head, E & Gunn-Moore, D 2021, ' Neuropathology of aging in cats and its similarities to human Alzheimer’s disease ', Frontiers in Aging . https://doi.org/10.3389/fragi.2021.684607
Elderly cats develop age-related behavioral and neuropathological changes that ultimately lead to cognitive dysfunction syndrome (CDS). These neuropathologies share similarities to those seen in the brains of humans with Alzheimer’s disease (AD), i
Autor:
Sandra McCutcheon, Jan P M Langeveld, Boon Chin Tan, Andrew C Gill, Christopher de Wolf, Stuart Martin, Lorenzo Gonzalez, James Alibhai, A Richard Alejo Blanco, Lauren Campbell, Nora Hunter, E Fiona Houston
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e91143 (2014)
This paper describes the generation, characterisation and potential applications of a panel of novel anti-prion protein monoclonal antibodies (mAbs). The mAbs were generated by immunising PRNP null mice, using a variety of regimes, with a truncated f
Externí odkaz:
https://doaj.org/article/7f007eebf1c94d43b389ffefa6dac410
Autor:
D. Becher, Sandra McCutcheon, Jean Manson, Allister Smith, Marc Turner, Martin H. Groschup, Paula Stewart, A. Richard Alejo Blanco, Boon Chin Tan, M. Khalid F. Salamat, E. Fiona Houston, Helen Brown, Olivier Andreoletti, Christopher De Wolf
Publikováno v:
Salamat, K, Alejo-Blanco, R, McCutcheon, S, Tan, K B C, Stewart, P, Brown, H, Smith, A, De Wolf, C, Groschup, M, Becher, D, Andreoletti, O, Turner, M, Manson, J & Houston, F 2021, ' Preclinical transmission of prions by blood transfusion is influenced by donor genotype and route of infection. ', PLoS Pathogens, vol. 17, no. 2, e1009276 . https://doi.org/10.1371/journal.ppat.1009276
PLoS Pathogens, Vol 17, Iss 2, p e1009276 (2021)
PLoS Pathogens
PLoS Pathogens, Public Library of Science, 2021, 17 (2), pp.e1009276. ⟨10.1371/journal.ppat.1009276⟩
PLoS Pathogens, Vol 17, Iss 2, p e1009276 (2021)
PLoS Pathogens
PLoS Pathogens, Public Library of Science, 2021, 17 (2), pp.e1009276. ⟨10.1371/journal.ppat.1009276⟩
Variant Creutzfeldt-Jakob disease (vCJD) is a human prion disease resulting from zoonotic transmission of bovine spongiform encephalopathy (BSE). Documented cases of vCJD transmission by blood transfusion necessitate on-going risk reduction measures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50f23ccd8666b9882d106b806847778c
https://hdl.handle.net/20.500.11820/06d78366-1834-4e9c-a6b9-390f6626d963
https://hdl.handle.net/20.500.11820/06d78366-1834-4e9c-a6b9-390f6626d963
Autor:
Sandra McCutcheon, Anthony Richard Alejo Blanco, E Fiona Houston, Christopher de Wolf, Boon Chin Tan, Antony Smith, Martin H Groschup, Nora Hunter, Valerie S Hornsey, Ian R MacGregor, Christopher V Prowse, Marc Turner, Jean C Manson
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23169 (2011)
Variant CJD (vCJD) is an incurable, infectious human disease, likely arising from the consumption of BSE-contaminated meat products. Whilst the epidemic appears to be waning, there is much concern that vCJD infection may be perpetuated in humans by t
Externí odkaz:
https://doaj.org/article/9787d6f5dbc047c7b4ad98b09f517ea9
Autor:
Sandra, McCutcheon, A Richard, Alejo Blanco, Boon Chin, Tan, Lorenzo, González, Stuart, Martin, Gary, Mallinson, Nigel E, Appleford, Marc L, Turner, Jean C, Manson, E Fiona, Houston
Publikováno v:
Transfusion. 55(9)
Variant Creutzfeldt-Jakob disease (vCJD) is a transmissible spongiform encephalopathy affecting humans, acquired initially through infection with bovine spongiform encephalopathy (BSE). A small number of vCJD cases have been acquired through the tran
Publikováno v:
Transfusion. 42:517-526
BACKGROUND: It is not known whether variant CJD can be transmitted within the human population by blood transfusion. The expression of normal cellular prion protein (PrPC) by different blood cell types may permit selective uptake and dissemination of