Zobrazeno 1 - 10
of 1 102
pro vyhledávání: '"E. Ferrell"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Self-regenerating trigger waves can spread rapidly through the crowded cytoplasm without diminishing in amplitude or speed, providing consistent, reliable, long-range communication. The macromolecular concentration of the cytoplasm varies in
Externí odkaz:
https://doaj.org/article/55dad6736b064e9dac6d1f32700c73bc
Autor:
Shixuan Liu, Camille Ezran, Michael F. Z. Wang, Zhengda Li, Kyle Awayan, The Tabula Microcebus Consortium, Jonathan Z. Long, Iwijn De Vlaminck, Sheng Wang, Jacques Epelbaum, Christin S. Kuo, Jérémy Terrien, Mark A. Krasnow, James E. Ferrell
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-27 (2024)
Abstract Hormones mediate long-range cell communication and play vital roles in physiology, metabolism, and health. Traditionally, endocrinologists have focused on one hormone or organ system at a time. Yet, hormone signaling by its very nature conne
Externí odkaz:
https://doaj.org/article/238c63958cb94f9a87c3cbab28ca495c
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract It has been proposed that the concentration of proteins in the cytoplasm maximizes the speed of important biochemical reactions. Here we have used Xenopus egg extracts, which can be diluted or concentrated to yield a range of cytoplasmic pro
Externí odkaz:
https://doaj.org/article/c64701f7129f4a05846bb1a59a7accb3
Autor:
Jinhee Kim, Deepanwita Bose, Mariluz Araínga, Muhammad R. Haque, Christine M. Fennessey, Rachel A. Caddell, Yanique Thomas, Douglas E. Ferrell, Syed Ali, Emanuelle Grody, Yogesh Goyal, Claudia Cicala, James Arthos, Brandon F. Keele, Monica Vaccari, Ramon Lorenzo-Redondo, Thomas J. Hope, Francois Villinger, Elena Martinelli
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract HIV-1 persistence during ART is due to the establishment of long-lived viral reservoirs in resting immune cells. Using an NHP model of barcoded SIVmac239 intravenous infection and therapeutic dosing of anti-TGFBR1 inhibitor galunisertib (LY2
Externí odkaz:
https://doaj.org/article/fbe3b5ac6da84f6e995899f2ef2ce0bd
Autor:
Jinhee Kim, Deepanwita Bose, Mariluz Araínga, Muhammad R. Haque, Christine M. Fennessey, Rachel A. Caddell, Yanique Thomas, Douglas E. Ferrell, Syed Ali, Emanuelle Grody, Yogesh Goyal, Claudia Cicala, James Arthos, Brandon F. Keele, Monica Vaccari, Ramon Lorenzo-Redondo, Thomas J. Hope, Francois Villinger, Elena Martinelli
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/d4eafc33aa964eaaa8d6b74d7af7c6e2
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Cytoplasmic organization is a hallmark of living cells. Here, the authors make use of self-organizing cell extracts to examine how the emergence of large-scale organizations influences the microscopic diffusion of protein molecules in the cytoplasm.
Externí odkaz:
https://doaj.org/article/9035452d6e1a41d19d0aafb54e833484
Autor:
Yuping Chen, James E. Ferrell
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Phase separation phenomena have emerged as being of critical importance in biology. Here, using colony formation in C. elegans as model, the authors demonstrate that the basic concepts that underpin phase separation at a molecular level also apply to
Externí odkaz:
https://doaj.org/article/2186e17d89014fbe9dfb03a2fd9dcf7d
Publikováno v:
eLife, Vol 9 (2020)
Mitosis is a dramatic process that affects all parts of the cell. It is driven by an oscillator whose various components are localized in the nucleus, centrosome, and cytoplasm. In principle, the cellular location with the fastest intrinsic rhythm sh
Externí odkaz:
https://doaj.org/article/bc35732050cb46d3b9126a32d9d9ecbd
Autor:
Sarah Lockhead, Alisa Moskaleva, Julia Kamenz, Yuxin Chen, Minjung Kang, Anay R. Reddy, Silvia D.M. Santos, James E. Ferrell, Jr.
Publikováno v:
Cell Reports, Vol 32, Iss 2, Pp 107901- (2020)
Summary: Protein synthesis inhibitors (e.g., cycloheximide) block mitotic entry, suggesting that cell cycle progression requires protein synthesis until right before mitosis. However, cycloheximide is also known to activate p38 mitogen-activated prot
Externí odkaz:
https://doaj.org/article/c582167df43d4122bace8434cabc65e8
Publikováno v:
Cell Reports, Vol 21, Iss 1, Pp 37-46 (2017)
The early Xenopus laevis embryo is replete with dynamic spatial waves. One such wave, the cell division wave, emerges from the collective cell division timing of first tens and later hundreds of cells throughout the embryo. Here, we show that cell di
Externí odkaz:
https://doaj.org/article/a5c4fb60964a4064a2e1eb37909abbb9