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'Dottyville'--Craiglockhart War Hospital and shell-shock treatment in the First World War

Autor: Thomas E F Webb

Publikováno v: Journal of the Royal Society of Medicine. 99:342-346

‘... THAT MECCA OF PSYCHO-NEUROSES...’1 Craiglockhart is perhaps the most famous shell-shock hospital. It was set up to deal with the epidemic of psychological casualties created in the muddy trenches of the First World War; and, in particular, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b7d78ee7ccebf75983995395df6cfbc9
https://doi.org/10.1258/jrsm.99.7.342

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Inhibition of contact sensitivity in human CD4+transgenic mice by human CD4-specific monoclonal antibodies: CD4+T-cell depletion is not required

Autor: A. Truneh, E. F. Webb, Don E. Griswold, P. L. Podolin, M.P. Reddy

Publikováno v: Immunology. 99:287-295

Summary Clenoliximab and keliximab are monkey/human chimeric monoclonal antibodies (mAbs) of the immunoglobulin G4 (IgG4) and IgG1 isotypes, respectively, that recognize the same epitope on human CD4. The two mAbs possess identical idiotypes and exhi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cda878d77170c0acf1b28bc61ce6741a
https://doi.org/10.1046/j.1365-2567.2000.00946.x

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Induction of plasma exudation and inflammatory cell infiltration by leukotriene C4 and leukotriene B4 in mouse peritonitis

Autor: Don E. Griswold, E. F. Webb, L. M. Hillegass

Publikováno v: Inflammation. 15:251-258

Leukotriene induction of the fluid and cellular phases of the inflammatory response in the mouse was evaluated. Intraperitoneal injection of leukotriene C4 (LTC4 250 ng) led to dye extravasation but not polymorphonuclear leukocyte (PMN) infiltration,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c8eae052339be7fe44d830b2099ba4c
https://doi.org/10.1007/bf00917310

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Inherited prion disease with 5-OPRI: phenotype modification by repeat length and codon 129

Autor: Lawrence J. Doey, Jeannine M. Heckmann, S. Rutherfoord, Simon Mead, Jm M. Linehan, J Wadsworth, James M. Beck, S Wroe, Ta A. Campbell, John Collinge, Tef E. F. Webb, Susan Joiner, Andrew T. King

Publikováno v: Neurology. 69(8)

Background: Humanprion diseases have sporadic, acquired and inherited etiologies and show considerable phenotypic heterogeneity. An individual inherited prion disease offers an opportunity to study the determinants of this clinicopathologic heterogen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71a73eff359ac93df8e13ebe89dbc7fd
https://pubmed.ncbi.nlm.nih.gov/17709704

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Nonpeptide tachykinin receptor antagonists. II. Pharmacological and pharmacokinetic profile of SB-222200, a central nervous system penetrant, potent and selective NK-3 receptor antagonist

Autor: H M, Sarau, D E, Griswold, B, Bush, W, Potts, P, Sandhu, D, Lundberg, J J, Foley, D B, Schmidt, E F, Webb, L D, Martin, J J, Legos, R G, Whitmore, F C, Barone, A D, Medhurst, M A, Luttmann, G A, Giardina, D W, Hay

Publikováno v: The Journal of pharmacology and experimental therapeutics. 295(1)

The pharmacological and pharmacokinetic profile of SB-222200 [(S)-(-)-N-(alpha-ethylbenzyl)-3-methyl-2-phenylquinoline-4-car boxami de], a human NK-3 receptor (hNK-3R) antagonist, was determined. SB-222200 inhibited (125)I-[MePhe(7)]neurokinin B (NKB

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cd478ee8b89d7e1dead7891aa99f62eb
https://pubmed.ncbi.nlm.nih.gov/10992004

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SB 239063, a potent p38 MAP kinase inhibitor, reduces inflammatory cytokine production, airways eosinophil infiltration, and persistence

Autor: D C, Underwood, R R, Osborn, C J, Kotzer, J L, Adams, J C, Lee, E F, Webb, D C, Carpenter, S, Bochnowicz, H C, Thomas, D W, Hay, D E, Griswold

Publikováno v: The Journal of pharmacology and experimental therapeutics. 293(1)

The anti-inflammatory/antiallergic activity of a novel second-generation p38 mitogen-activated protein kinase inhibitor, SB 239063[trans-1-(4-hydroxycyclohexyl) -4-(4-fluorophenyl)-5-(2-methoxypyridimidin-4-yl)imidazole], was investigated in vivo and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8ad7ba37cf0e2b9aba0d71fd1b23c0b7
https://pubmed.ncbi.nlm.nih.gov/10734180

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SB 207499 (Ariflo), a second generation phosphodiesterase 4 inhibitor, reduces tumor necrosis factor alpha and interleukin-4 production in vivo

Autor: D E, Griswold, E F, Webb, A M, Badger, P D, Gorycki, P A, Levandoski, M A, Barnette, M, Grous, S, Christensen, T J, Torphy

Publikováno v: The Journal of pharmacology and experimental therapeutics. 287(2)

The ability of the second generation phosphodiesterase 4 inhibitor SB 207499 (Ariflo), [c-4-cyano-4-(3-cyclopentyloxy-4-methoxyphenyl)-r-l-cyclohexane carboxylic acid], to inhibit inflammatory cytokine production in vivo was evaluated and compared to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e27ad0460a9a5b73d7148b301eb89bc1
https://pubmed.ncbi.nlm.nih.gov/9808700

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Nonpeptide tachykinin receptor antagonists: I. Pharmacological and pharmacokinetic characterization of SB 223412, a novel, potent and selective neurokinin-3 receptor antagonist

Autor: H M, Sarau, D E, Griswold, W, Potts, J J, Foley, D B, Schmidt, E F, Webb, L D, Martin, M E, Brawner, N A, Elshourbagy, A D, Medhurst, G A, Giardina, D W, Hay

Publikováno v: The Journal of pharmacology and experimental therapeutics. 281(3)

The in vitro and in vivo pharmacological profile of SB 223412 [(S)-(-)-N-(alpha-ethylbenzyl)-3-hydroxy-2-phenylquinoline-4-carbo xamide], a novel human NK-3 (hNK-3) receptor antagonist, is described. SB 223412 demonstrated enantioselective affinity f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9951a6d4717be264b3c6bd0fae47f6ba
https://pubmed.ncbi.nlm.nih.gov/9190866

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Pyridinyl imidazoles inhibit the inflammatory phase of delayed type hypersensitivity reactions without affecting T-dependent immune responses

Autor: D. Maley, J. C. Lee, D.E. Griswold, A. Truneh, M.P. Reddy, E. F. Webb, D. Cassatt

Publikováno v: International journal of immunopharmacology. 16(10)

The effects of pyridinyl imidazoles, specifically SK&F 105809 and its metabolite, on normal T-cell and B-cell mediated immune responses examined and compared to the fungal macrolide immunosuppressives, cyclosporin A, FK506 and rapamycin and to the co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f90989531f2ae7228f7750d873bb181
https://pubmed.ncbi.nlm.nih.gov/7843851

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Effects of scalaradial, a type II phospholipase A2 inhibitor, on human neutrophil arachidonic acid mobilization and lipid mediator formation

Autor: L A, Marshall, J D, Winkler, D E, Griswold, B, Bolognese, A, Roshak, C M, Sung, E F, Webb, R, Jacobs

Publikováno v: The Journal of pharmacology and experimental therapeutics. 268(2)

The role of scalaradial (SLD) (or its 12-epi analog), a marine natural product purified from sponge (Cacospongia mollior) in human neutrophil (polymorphonuclear leukocyte, PMN) arachidonic acid metabolism was studied. SLD potently inhibited human rec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::79839ebf4a55683ef1b92778035877ee
https://pubmed.ncbi.nlm.nih.gov/8113982

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