Zobrazeno 1 - 10
of 34
pro vyhledávání: '"E. F. Shibata"'
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 9
International Journal of Molecular Sciences, Vol 22, Iss 4761, p 4761 (2021)
Volume 22
Issue 9
International Journal of Molecular Sciences, Vol 22, Iss 4761, p 4761 (2021)
Robust, spontaneous pacemaker activity originating in the sinoatrial node (SAN) of the heart is essential for cardiovascular function. Anatomical, electrophysiological, and molecular methods as well as mathematical modeling approaches have quite thor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::febad0dd7e6a01e1a19184aeecf6f3b7
http://europepmc.org/articles/PMC8124469
http://europepmc.org/articles/PMC8124469
Publikováno v:
Molecular Pharmacology. 62:127-134
A-type K+ currents serve important functions in neural and cardiac physiology. The human A-type Kv1.4 channel (hKv1.4) shows fast N-type inactivation when expressed in Xenopus laevis oocytes. We found that intracellular pH (pH(i)) regulated the macro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f37bab7f0dc273e80beb59acf00d21d
https://doi.org/10.1124/mol.62.1.127
https://doi.org/10.1124/mol.62.1.127
Publikováno v:
Circulation Research. 90:443-449
This study demonstrates that caveolae, omega-shaped membrane invaginations, are involved in cardiac sodium channel regulation by a mechanism involving the α subunit of the stimulatory heterotrimeric G-protein, Gα s , via stimulation of the cell sur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af48a81ba05abd4d2714f78d944ca9b0
https://doi.org/10.1161/hh0402.105177
https://doi.org/10.1161/hh0402.105177
Publikováno v:
The Journal of General Physiology
Dihydropyridines (DHPs) are well known for their effects on L-type voltage-dependent Ca2+ channels. However, these drugs also affect other voltage-dependent ion channels, including Shaker K+ channels. We examined the effects of DHPs on the Shaker K+
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::668c7eab5b22806cdd1807c2838977ee
https://doi.org/10.1085/jgp.109.2.169
https://doi.org/10.1085/jgp.109.2.169
Publikováno v:
Circulation Research. 75:742-750
Whole-cell patch-clamp techniques were used to study enzymatically dispersed epicardial coronary artery smooth muscle cells. Depolarizing voltage pulses of 500-millisecond duration from -60 mV (118 mmol/L CsCl, 22 mmol/L tetraethylammonium chloride,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49c311ed39602760018eca0d4b05c567
https://doi.org/10.1161/01.res.75.4.742
https://doi.org/10.1161/01.res.75.4.742
Publikováno v:
Frontiers in Physiology, Vol 2 (2011)
Frontiers in Physiology
Frontiers in Physiology
Recent studies of cholesterol-rich membrane microdomains, called caveolae, reveal that caveolae are reservoirs of “recruitable” sodium ion channels. Caveolar channels constitute a substantial and previously unrecognized source of sodium current i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68544cc410ead7bac88cac7ff354cb80
https://doi.org/10.3389/fphys.2011.00087
https://doi.org/10.3389/fphys.2011.00087
Autor:
K A Volk, E. F. Shibata
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 264:H1146-H1153
Cell-attached patches from rabbit coronary artery single smooth muscle cells contained two distinct potassium channel types, namely a large conductance calcium-activated potassium channel and a smaller voltage-activated potassium channel representing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f7cd97eb7fdc7409f04c173dfacd5c5
https://doi.org/10.1152/ajpheart.1993.264.4.h1146
https://doi.org/10.1152/ajpheart.1993.264.4.h1146
Publikováno v:
American journal of physiology. Heart and circulatory physiology. 294(4)
Cardiac sodium channels (voltage-gated Na+ channel subunit 1.5) reside in both the plasmalemma and membrane invaginations called caveolae. Opening of the caveolar neck permits resident channels to become functional. In cardiac myocytes, caveolar open
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93b51008b625abb10453bcbde895b9ab
https://pubmed.ncbi.nlm.nih.gov/18281377
https://pubmed.ncbi.nlm.nih.gov/18281377
Publikováno v:
The Journal of Physiology. 427:657-680
1. Calcium inward currents were recorded from relaxed enzymatically isolated smooth muscle cells from the rabbit epicardial left descending coronary artery using a single-pipette voltage-clamp technique. Outward K+ currents were blocked with CsCl-tet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5794ac0368ca6e58b0ffbdf0cd25775
https://doi.org/10.1113/jphysiol.1990.sp018192
https://doi.org/10.1113/jphysiol.1990.sp018192
Autor:
E. F. Shibata
Publikováno v:
Endocrinology. 131:979-981
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd15f3456c41ac6c96ff559c33c0327f
https://doi.org/10.1210/en.131.2.979
https://doi.org/10.1210/en.131.2.979