Zobrazeno 1 - 10
of 36
pro vyhledávání: '"E. F. Llama"'
Publikováno v:
Enzyme and Microbial Technology. 30:895-901
The synthesis of ( R ) or ( S ) 1-chloro-3-(1-naphthyloxy)propan-2-ol, (2-Propranolol precursor) using yeast-catalysed reduction of 1-chloro-3-(1-naphthyloxy)propan-2-one, 1 is described. Several yeast strains have been used. The best strains were se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b790556c750bd664cdc0c2cfd09590cf
https://doi.org/10.1016/s0141-0229(02)00023-6
https://doi.org/10.1016/s0141-0229(02)00023-6
Publikováno v:
Biocatalysis and Biotransformation. 19:163-180
The importance of the adrenergic β-blockers with structure of (S) 1-aryloxy-3-amino-2-propanol in the treatment of different diseases has led the development of a variety of stereoselective synthetic methodologies for this stereoisomer. In this revi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e48d54347956a49d3c46249bcc1a9abf
https://doi.org/10.3109/10242420109105262
https://doi.org/10.3109/10242420109105262
Publikováno v:
Tetrahedron: Asymmetry. 11:4651-4660
The preparation of halohydrin β-blocker precursors using yeast-catalysed reduction of α-haloketones was performed. The influence in the yield and e.e. of several process variables was analysed. The (S)-enantioselectivity observed with Saccharomyces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8857fdceeb0868542a01a6e569ad3ad3
https://doi.org/10.1016/s0957-4166(00)00425-0
https://doi.org/10.1016/s0957-4166(00)00425-0
Publikováno v:
Tetrahedron: Asymmetry. 10:3507-3514
The stereochemistry of the Candida antarctica lipase B (CALB) catalyzed resolution of diacetate 1 or diol 4 was analyzed. The primary and secondary acetate hydrolyses were studied separately using monoacetates 2 and 3 . The enantioselectivity of CALB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9320be909f5f9da51327c6504ed0dab2
https://doi.org/10.1016/s0957-4166(99)00366-3
https://doi.org/10.1016/s0957-4166(99)00366-3
Publikováno v:
Tetrahedron Letters. 38:4137-4140
Amino-2-propanol structures can be obtained by addition to dibenzyl acetals of in situ generated dihalocarbenes using LVT (Low Valent Titanium). This methodology can be used to obtain adrenergic β-blockers with amino-2-propanol structure. Tetrahalom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::892d161ae944a51f26c0b35a2682b05c
https://doi.org/10.1016/s0040-4039(97)00804-6
https://doi.org/10.1016/s0040-4039(97)00804-6
Autor:
E. F. Llama, Ana Gradillas, C. Del Campo, J.M. Sánchez-Montero, M. Garcia, Jose‐Vicente Sinisterra
Publikováno v:
Biotechnology Letters. 19:999-1004
sThe hydrolysis of several esters catalyzed by lipase of Candida rugosa was used to analyse the interaction between the ester substrate and the active site and the geometry and steric restrictions of ‘alk‘, ‘ar‘ and ‘h‘ subsites. Using 4-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae29e4e452f9bc2cb4a66e711e5d0980
https://doi.org/10.1023/a:1018447301016
https://doi.org/10.1023/a:1018447301016
Publikováno v:
Tetrahedron: Asymmetry. 7:2485-2488
CAL offers increased ee, together with broad substrate structural tolerance that makes it a firm candidate for the resolution of BBAs of type 1 .
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ea75293d345bfa7d1d9ac6d31de96a2
https://doi.org/10.1016/0957-4166(96)00313-8
https://doi.org/10.1016/0957-4166(96)00313-8
Publikováno v:
Tetrahedron: Asymmetry. 7:2627-2631
Synthesis of enantiomerically pure ( S )-(−)-propranolol, the most active of the widely used beta-blockers adrenergics, was achieved using a new chiral stationary phase (CSP) for the separation of a derivative. This simple methodology shows a signi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e607e5da7d1649c4654a7fb32e883bdc
https://doi.org/10.1016/0957-4166(96)00337-0
https://doi.org/10.1016/0957-4166(96)00337-0
Publikováno v:
Journal of Molecular Catalysis A: Chemical. 95:179-192
The alteration of the selectivity of enzymes due to the immobilization methodology is discussed. The hydrolysis of esters of ( R,S ) 2-phenyl propionic and 2-phenyl butyric acids has been used as a reaction test. Lipases from Candida cylindracea immo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b59aaf8951b1d5244d6c89c3e739fce
https://doi.org/10.1016/1381-1169(94)00006-9
https://doi.org/10.1016/1381-1169(94)00006-9
Autor:
José María Borrás Moreno, María José Cabezas, Carmen del Campo, José V. Sinisterra, E. F. Llama, Miguel Arroyo
Publikováno v:
J. Chem. Soc., Perkin Trans. 2. :1333-1336
The chemical modification of α-chymotrypsin by monomethoxypolyethylene glycol and the immobilization of lipases from Candida rugosa and C. antarctica on several supports changes the enantioselectivity of the enzymatic derivatives compared with the b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e326d420f0c3cf3ee4e11a7c823f9cb1
https://doi.org/10.1039/p29940001333
https://doi.org/10.1039/p29940001333