An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans

Autor: Rob M. van Dam, Francis S. Collins, Konstantin Strauch, Raimund Erbel, Rafn Benediktsson, Philippe Froguel, Kyle J. Gaulton, Peter Donnelly, Torben Hansen, Longda Jiang, Lennart C. Karssen, Rona J. Strawbridge, David J. Hunter, Leena Kinnunen, Thomas Meitinger, Michael Stumvoll, Stéphane Cauchi, Ching-Ti Liu, Olga McLeod, Oluf Pedersen, Michael Boehnke, Denis Rybin, Karl Gertow, Tõnu Esko, Bernhard O. Boehm, Sonali Pechlivanis, Bo Isomaa, Anne U. Jackson, Clement Ma, Yingchang Lu, Nicola D. Kerrison, Ruth J. F. Loos, Caroline S. Fox, Chiara Scapoli, Jian'an Luan, Martina Müller-Nurasyid, Domenico Palli, Anke Tönjes, Natalie R. van Zuydam, Neil Robertson, Barbara Thorand, Natalia Pervjakova, Andrew R. Wood, Karin Leander, Unnur Thorsteinsdottir, Sara M. Willems, Karen L. Mohlke, Robert A. Scott, Markus M. Nöthen, Ulf de Faire, Qi Sun, Eric Boerwinkle, Roman Wennauer, Douglas M. Ruderfer, Marika Kaakinen, Nigel W. Rayner, Jaakko Tuomilehto, Nisa M. Maruthur, Richard N. Bergman, Janina S. Ried, Himanshu Chheda, Josée Dupuis, Juan Tajes-Fernandes, Steve E. Humphries, Reedik Mägi, Gonçalo R. Abecasis, B F Voight, David Couper, Cornelia M. van Duijn, Samuli Ripatti, Yeji Lee, Heikki A. Koistinen, Christian Dina, Andres Metspalu, Lu Qi, James S. Pankow, Han Chen, Damiano Baldassarre, Mattias Frånberg, Gerald Steinbach, Inga Prokopenko, Matthias Blüher, Jose C. Florez, Julia Meyer, Niels Grarup, Anders Hamsten, Valeriya Lyssenko, James B. Meigs, Pritam Chanda, Leif Groop, Sarah Edkins, Anubha Mahajan, Gunnar Sigurðsson, Marilyn C. Cornelis, Christian Gieger, Nancy L. Pedersen, Andrew T. Hattersley, Paul W. Franks, Nicholas J. Wareham, Stefan Gustafsson, Katharine R. Owen, Peter Kovacs, Andrew D. Johnson, Lori L. Bonnycastle, Tiinamaija Tuomi, Aurelio Barricarte Gurrea, Tune H. Pers, Eric J.G. Sijbrands, Phoenix Kwan, Emmi Tikkanen, Elisabeth M. van Leeuwen, Stéphane Lobbens, Claudia Langenberg, E. Eury, Thomas W. Mühleisen, Lewin Eisele, Veikko Salomaa, Satu Mӓnnistö, Christian Fuchsberger, Evelin Mihailov, David Altshuler, Timothy M. Frayling, Peter Almgren, Harald Grallert, Hans A. Kestler, Beverley Balkau, Erik Ingelsson, Colin N. A. Palmer, Yvonne T. van der Schouw, Michael Roden, Thomas Sparsø, Karl-Heinz Jöckel, Johan G. Eriksson, Inês Barroso, John D. Eicher, Bengt Sennblad, Bruna Gigante, Andrew D. Morris, Panagiotis Deloukas, Man Li, Allan Linneberg, Astradur B. Hreidarsson, Lars Lannfelt, Elena Tremoli, Liming Liang, Omri Gottesman, Letizia Marullo, Peter S. Chines, Kari Stefansson, Mark I. McCarthy, Andrew P. Morris, Erwin P. Bottinger, Augustine Kong, Torben Jørgensen, Tanya M. Teslovich, Frank B. Hu, Dorothée Thuillier, Peter Kraft, Heiner Boeing, Laura J. Scott, Gudmar Thorleifsson, Lars Lind, John R. B. Perry, Heather M. Stringham, Susanne Moebus, Valgerdur Steinthorsdottir, Cecilia M. Lindgren, Guillaume Charpentier, Eleftheria Zeggini, Leena Peltonen, Loic Yengo, Norman Klopp, Teresa Ferreira, Christian Theil Have, Marit E. Jørgensen

Publikováno v: Scott, R A, Scott, L J, Mägi, R, Marullo, L, Gaulton, K J, Kaakinen, M, Pervjakova, N, Pers, T H, Johnson, A D, Eicher, J D, Jackson, A U, Ferreira, T, Lee, Y, Ma, C, Steinthorsdottir, V, Thorleifsson, G, Qi, L, Van Zuydam, N R, Mahajan, A, Chen, H, Almgren, P, Voight, B F, Grallert, H, Müller-Nurasyid, M, Ried, J S, Rayner, N W, Robertson, N R, Karssen, L C, van Leeuwen, E M, Willems, S M, Fuchsberger, C, Kwan, P, Teslovich, T M, Chanda, P, Li, M, Lu, Y, Dina, C, Thuillier, D, Yengo, L, Jiang, L, Sparso, T, Kestler, H A, Chheda, H, Eisele, L, Gustafsson, S, Frånberg, M, Strawbridge, R J, Benediktsson, R, Hreidarsson, A B, Jørgensen, T & DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium 2017, ' An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans ', Diabetes, vol. 66, no. 11, pp. 2888-2902 . https://doi.org/10.2337/db16-1253
Diabetes 66, 2888-2902 (2017)
Diabetes, 66(11), 2888-2902. American Diabetes Association Inc.
Scott, R A, Scott, L J, Mägi, R, Marullo, L, Gaulton, K J, Kaakinen, M, Pervjakova, N, Pers, T H, Johnson, A D, Eicher, J D, Jackson, A U, Ferreira, T, Lee, Y, Ma, C, Steinthorsdottir, V, Thorleifsson, G, Qi, L, Van Zuydam, N R, Mahajan, A, Chen, H, Almgren, P, Voight, B F, Grallert, H, Müller-nurasyid, M, Ried, J S, Rayner, W N, Robertson, N, Karssen, L C, Van Leeuwen, E M, Willems, S M, Fuchsberger, C, Kwan, P, Teslovich, T M, Chanda, P, Li, M, Lu, Y, Dina, C, Thuillier, D, Yengo, L, Jiang, L, Sparso, T, Kestler, H A, Chheda, H, Eisele, L, Gustafsson, S, Frånberg, M, Strawbridge, R J, Benediktsson, R, Hreidarsson, A B, Kong, A, Sigurðsson, G, Kerrison, N D, Luan, J, Liang, L, Meitinger, T, Roden, M, Thorand, B, Esko, T, Mihailov, E, Fox, C, Liu, C, Rybin, D, Isomaa, B, Lyssenko, V, Tuomi, T, Couper, D J, Pankow, J S, Grarup, N, Have, C T, Jørgensen, M E, Jørgensen, T, Linneberg, A, Cornelis, M C, Van Dam, R M, Hunter, D J, Kraft, P, Sun, Q, Edkins, S, Owen, K R, Perry, J R, Wood, A R, Zeggini, E, Tajes-fernandes, J, Abecasis, G R, Bonnycastle, L L, Chines, P S, Stringham, H M, Koistinen, H A, Kinnunen, L, Sennblad, B, Mühleisen, T W, Nöthen, M M, Pechlivanis, S, Baldassarre, D, Gertow, K, Humphries, S E, Tremoli, E, Klopp, N, Meyer, J, Steinbach, G, Wennauer, R, Eriksson, J G, Mӓnnistö, S, Peltonen, L, Tikkanen, E, Charpentier, G, Eury, E, Lobbens, S, Gigante, B, Leander, K, Mcleod, O, Bottinger, E P, Gottesman, O, Ruderfer, D, Blüher, M, Kovacs, P, Tonjes, A, Maruthur, N M, Scapoli, C, Erbel, R, Jöckel, K, Moebus, S, De Faire, U, Hamsten, A, Stumvoll, M, Deloukas, P, Donnelly, P J, Frayling, T M, Hattersley, A T, Ripatti, S, Salomaa, V, Pedersen, N L, Boehm, B O, Bergman, R N, Collins, F S, Mohlke, K L, Tuomilehto, J, Hansen, T, Pedersen, O, Barroso, I, Lannfelt, L, Ingelsson, E, Lind, L, Lindgren, C M, Cauchi, S, Froguel, P, Loos, R J, Balkau, B, Boeing, H, Franks, P W, Gurrea, A B, Palli, D, Van Der Schouw, Y T, Altshuler, D, Groop, L C, Langenberg, C, Wareham, N J, Sijbrands, E, Van Duijn, C M, Florez, J C, Meigs, J B, Boerwinkle, E, Gieger, C, Strauch, K, Metspalu, A, Morris, A D, Palmer, C N, Hu, F B, Thorsteinsdottir, U, Stefansson, K, Dupuis, J, Morris, A P, Boehnke, M, Mccarthy, M I & Prokopenko, I 2017, ' An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans ', Diabetes, pp. db161253 . https://doi.org/10.2337/db16-1253
Scott, R A, Scott, L J, Mägi, R, Marullo, L, Gaulton, K J, Kaakinen, M, Pervjakova, N, Pers, T H, Johnson, A D, Eicher, J D, Jackson, A U, Ferreira, T, Lee, Y, Ma, C, Steinthorsdottir, V, Thorleifsson, G, Qi, L, Van Zuydam, N R, Mahajan, A, Chen, H, Almgren, P, Voight, B F, Grallert, H, Müller-Nurasyid, M, Ried, J S, Rayner, N W, Robertson, N, Karssen, L C, van Leeuwen, E M, Willems, S M, Fuchsberger, C, Kwan, P, Teslovich, T M, Chanda, P, Li, M, Lu, Y, Dina, C, Thuillier, D, Yengo, L, Jiang, L, Sparso, T, Kestler, H A, Chheda, H, Eisele, L, Gustafsson, S, Frånberg, M, Strawbridge, R J, Benediktsson, R, Jørgensen, M E, Hansen, T & DIAGRAM Consortium 2017, ' An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans ', Diabetes, vol. 66, no. 11, pp. 2888-2902 . https://doi.org/10.2337/db16-1253
Diabetes
Diabetes, 66(11), 2888. American Diabetes Association Inc.
DIABETES

To characterize type 2 diabetes (T2D)-associated variation across the allele frequency spectrum, we conducted a meta-analysis of genome-wide association data from 26,676 T2D case and 132,532 control subjects of European ancestry after imputation usin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d43a331d53d3a1bc806c1e9fb787f732
https://vbn.aau.dk/da/publications/bc27dd82-ce45-4e74-a934-5ef0ac509e8e

Beneficial Metabolic Effects of Rapamycin Are Associated with Enhanced Regulatory Cells in Diet-Induced Obese Mice

Autor: Olivier Molendi-Coste, Bart Staels, E. Eury, Hélène Duez, Emmanuel Bouchaert, Isabelle Wolowczuk, Myriam Labalette, Stéphane Lobbens, Kassem Makki, Philippe Froguel, David Dombrowicz, Bernadette Neve, Solenne Taront

Publikováno v: PLoS ONE
PLoS ONE, Vol 9, Iss 4, p e92684 (2014)

The "mechanistic target of rapamycin" (mTOR) is a central controller of growth, proliferation and/or motility of various cell-types ranging from adipocytes to immune cells, thereby linking metabolism and immunity. mTOR signaling is overactivated in o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90c73895e95e8fa71a1e46556c900343
http://europepmc.org/articles/PMC3977858

Association between large detectable clonal mosaicism and type 2 diabetes with vascular complications

Autor: E. Eury, Amélie Bonnefond, Olivier Lantieri, Guillaume Charpentier, Philippe Froguel, Stéphane Cauchi, Beverley Balkau, Dorothée Thuillier, Michel Marre, Boris Skrobek, Stéphane Lobbens, Elio Riboli, Loic Yengo

Publikováno v: Nature genetics. 45(9)

Large chromosomal clonal mosaic events (CMEs) have been suggested to be linked to aging and to predict cancer. Type 2 diabetes (T2D) has been conceptualized as an accelerated-aging disease and is associated with higher prevalence of cancers. Here we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf7b08a9c56f86cbab30e59cf4715f92
https://pubmed.ncbi.nlm.nih.gov/23852171

O36 Methylation de l’ADN dans le foie et diabète de type 2

Autor: F. Pattou, Audrey Leloire, E. Eury, Mickaël Canouil, Loic Yengo, Stéphane Cauchi, O. Poulain, Stéphane Lobbens, Philippe Froguel

Publikováno v: Diabetes & Metabolism. 40:A9

Introduction Le foie joue un role majeur mais encore mal connu dans le risque de diabete de type 2 (DT2) dont l'heritabilite est en partie expliquee par des facteurs genetiques et epigenetiques. Notre projet a donc pour but d'identifier et de caracte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4fead6a6136b50aeff8df0833273f098
https://doi.org/10.1016/s1262-3636(14)72210-4

P2084 Méthylation de l’ADN dans le foie et diabète de type 2 : une étude pilote

Autor: F. Pattou, Philippe Froguel, Loic Yengo, Audrey Leloire, E. Eury, Stéphane Cauchi, O. Poulain

Publikováno v: Diabetes & Metabolism. 39:A88

Objectif L’objectif principal de cette etude est d’identifier des marqueurs epigenetiques associes au risque de diabete de type 2 (DT2) par leurs effets sur l’action de l’insuline Patients et methodes Nous avons realise une etude pilote en co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5d2c64c4415d751998643c8dd9223b66
https://doi.org/10.1016/s1262-3636(13)71994-3