Markedly divergent effects of Ouabain on a Temozolomide-resistant (T98G) vs. a Temozolomide-sensitive (LN229) Glioblastoma cell line

Autor: Heidrun Weidemann, Daniel Feger, Jan E. Ehlert, Marcus M. Menger, Robert C. Krempien

Publikováno v: Discover Oncology, Vol 14, Iss 1, Pp 1-16 (2023)

Abstract Background Glioblastoma multiforme (GBM) is the most aggressive primary brain tumor with poor prognosis. GMB are highly recurrent mainly because of radio- and chemoresistance. Radiotherapy with Temozolomide (TMZ) is until today the golden st

Externí odkaz: https://doaj.org/article/7012fe8fc5b94fe288b047c578a19fa0

Inhibition of Semaphorin3A Promotes Ocular Dominance Plasticity in the Adult Rat Visual Cortex

Autor: Laura Baroncelli, Tommaso Pizzorusso, James W. Fawcett, Fred de Winter, Erich M. E. Ehlert, Leonardo Lupori, Craig W. Vander Kooi, Elena Maria Boggio, Joost Verhaagen, Vasilis Mecollari, Elizabeth B. Moloney, Bas Blits

Publikováno v: Boggio, E M, Ehlert, E M, Lupori, L, Moloney, E B, De Winter, F, Vander Kooi, C W, Baroncelli, L, Mecollari, V, Blits, B, Fawcett, J W, Verhaagen, J & Pizzorusso, T 2019, ' Inhibition of Semaphorin3A Promotes Ocular Dominance Plasticity in the Adult Rat Visual Cortex ', Molecular Neurobiology, vol. 56, no. 9, pp. 5987-5997 . https://doi.org/10.1007/s12035-019-1499-0
Molecular Neurobiology, 56(9), 5987-5997. Humana Press
Molecular Neurobiology, 56, 5987-5997. Humana Press

Perineuronal nets (PNNs) are condensed structures in the extracellular matrix that mainly surround GABA-ergic parvalbumin-positive interneurons in the adult brain. Previous studies revealed a parallel between PNN formation and the closure of the crit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::933575a2d211a72a1948e455d1c352e6
http://www.scopus.com/inward/record.url?scp=85060998348&partnerID=8YFLogxK

Abstract 2893: Exploring the combinatorial potential of bispecific T-cell engagers in high throughput format

Autor: Carla N. Castro, Daniel Feger, Sarah Ulrich, Oliver Siedentopf, Jan E. Ehlert

Publikováno v: Cancer Research. 82:2893-2893

Bispecific antibodies are being explored as a means to modulate responses of the immune system to tumor infiltration. They are emerging as a growing class of immunotherapies with potential to further improve clinical efficacy and safety. Besides tumo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a30b340bd5f33f8acae42b1cade9a245
https://doi.org/10.1158/1538-7445.am2022-2893

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GFAP-driven GFP expression in activated mouse Müller glial cells aligning retinal blood vessels following intravitreal injection of AAV2/6 vectors.

Autor: Wendy M Aartsen, Koen W R van Cleef, Lucie P Pellissier, Robert M Hoek, Rogier M Vos, Bas Blits, Erich M E Ehlert, Kamaljit S Balaggan, Robin R Ali, Joost Verhaagen, Jan Wijnholds

Publikováno v: PLoS ONE, Vol 5, Iss 8, p e12387 (2010)

BackgroundMüller cell gliosis occurs in various retinal pathologies regardless of the underlying cellular defect. Because activated Müller glial cells span the entire retina and align areas of injury, they are ideal targets for therapeutic strategi

Externí odkaz: https://doaj.org/article/fbe4eb2ddd3748f092d1484bcd58d2f2