Zobrazeno 1 - 10 of 32 pro vyhledávání: '"E. Edward Mena"'
1
Isolation and Identification of Antifungal Fatty Acids from the Basidiomycete Gomphus floccosus
Autor: E Edward Mena, Stephen O. Duke, Bethany P Case, Toby M Kniffin, Charles L. Cantrell, David E. Wedge
Publikováno v: Journal of Agricultural and Food Chemistry. 56:5062-5068
Bioautography of extracts of the fruiting bodies of the basidiomycete Gomphus floccosus (Schw.) Singer indicated the presence of fungitoxic compounds in the ethyl acetate fraction against the plant pathogens Colletotrichum fragariae, Colletotrichum g
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84991a32252376afb3b12e7eb93683c1
https://doi.org/10.1021/jf8008662
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2
Characterization of L-Glutamate Binding Sites in Rat Spinal Cord Synaptic Membranes: Evidence for Multiple Chloride Ion-Dependent Sites
Autor: Martin J. Pagnozzi, Mary F. Gullak, E. Edward Mena
Publikováno v: Journal of Neurochemistry. 47:1052-1060
The effects of various ions on L-glutamate (L-Glu) binding sites (Na+-dependent, Cl(-)-dependent, and Cl(-)-independent) in synaptic plasma membranes (SPM) isolated from rat spinal cord and forebrain were examined. Cl(-)-dependent binding sites were
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64a8b097c730a2b1e7253593204928a7
https://doi.org/10.1111/j.1471-4159.1986.tb00719.x
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3
UK-78,282, a novel piperidine compound that potently blocks the Kv1.3 voltage-gated potassium channel and inhibits human T cell activation
Autor: John Charles Kath, Kimberly A. Verdries, Kevin Koch, Stephan Grissmer, Angela Nguyen, Paul C. Canniff, Ann C. Cunningham, Robert J. Mather, Matthew J. Bruns, Douglas C. Hanson, E. Edward Mena, K. George Chandy, Michael D. Cahalan, Carol B. Donovan, Heiko Rauer, Burgess Laurence E, George A. Gutman, James P. Rizzi
Publikováno v: British Journal of Pharmacology. 126:1707-1716
UK-78,282, a novel piperidine blocker of the T lymphocyte voltage-gated K+ channel, Kv1.3, was discovered by screening a large compound file using a high-throughput 86Rb efflux assay. This compound blocks Kv1.3 with a IC50 of ∼200 nM and 1 : 1 stoi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5614aea1bcf99c895891e01e439b04fa
https://doi.org/10.1038/sj.bjp.0702480
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5
[Untitled]
Autor: Manoj C. Desai, E. Edward Mena
Publikováno v: Pharmaceutical Research. :200-203
Tetrahydroaminoacridine (THA), an acetylcholinesterase inhibitor that is reported to have significant effects on cognition and memory in Alzheimer’s disease patients, binds to rat brain membranes in a saturable and reversible manner. Computer analy
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f8c54246706ac34ff46bec0430efcfcd
https://doi.org/10.1023/a:1015840003630
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6
Conantokin-G: A novel peptide antagonist to the acid (NMDA) receptor
Autor: Karl E.G. Richter, Baldomero M. Olivera, Lourdes J. Cruz, Mary F. Gullak, E. Edward Mena, Jean Rivier, Martin J. Pagnozzi
Publikováno v: Neuroscience Letters. 118:241-244
Conantokin-G is a 17 amino acid peptide isolated from the venom of the fish-eating snail Conus geographus which produces hyperactivity when injected into the brains of adult mice. We show that this peptide is a selective N- methyl- d -aspartate (NMDA
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d8d85a82598d801c29e53fc1cd425511
https://doi.org/10.1016/0304-3940(90)90637-o
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7
A unified approach to systematic isosteric substitution for acidic groups and application to NMDA antagonists related to 2-amino-7-phosphonoheptanoate
Autor: L. C. Marinovic, R. T. Ronau, Christopher A. Lipinski, Martin J. Pagnozzi, E. Edward Mena, G. C. Butterfield, Beryl W. Dominy, Bertrand L. Chenard, T. Tsang, Butler Todd W
Publikováno v: Journal of Medicinal Chemistry. 33:1077-1083
A systematic approach to the replacement of acidic groups with potential bioisosteres is described. The strategy involves simple nucleophilic displacement of a common alkyl halide precursor with a variety of mercaptoazoles and related molecules. The
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d71d71256e38828558dd436f990e8c8
https://doi.org/10.1021/jm00165a030
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8
(1S,2S)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidino)-1-propanol: a potent new neuroprotectant which blocks N-methyl-D-aspartate responses
Autor: Leslie K. Chambers, E. Edward Mena, Butler Todd W, M. L. Dumont, Bertrand L. Chenard, M. F. Ducat, Jon Bordner, Carol B. Fox, M. A. Collins, De Costa Dl
Publikováno v: Journal of medicinal chemistry. 38(16)
(1S,2S)-1-(4-Hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidino)-1-propanol (20, CP-101,606) has been identified as a potent and selective N-methyl-D-aspartate (NMDA) antagonist through a structure activity relation (SAR) program based on ifenprodil, a k
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40dda9aaf2b5f26f6b9469916edd00ae
https://pubmed.ncbi.nlm.nih.gov/7636876
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9
Diversity of Conus neuropeptides
Autor: Scott Woodward, David R. Hillyard, Jean Rivier, Cecilia A. Ramilo, Lourdes J. Cruz, Fe C. Abogadie, E. Edward Mena, Gloria P. Corpuz, Baldomero M. Olivera, Craig Clark
Publikováno v: Science (New York, N.Y.). 249(4966)
Conus venoms contain a remarkable diversity of pharmacologically active small peptides. Their targets are ion channels and receptors in the neuromuscular system. The venom of Conus geographus contains high-affinity peptides that act on voltage-sensit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e0412399d913cfc14c4b8e650ecff15
https://pubmed.ncbi.nlm.nih.gov/2165278
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10
L-glutamate and l-aspartate bind to separate sites in rat brain synaptic membranes
Autor: Graham E. Fagg, Carl W. Cotman, Alan C. Foster, E. Edward Mena
Publikováno v: Brain Research. 229:246-250
Summary The specific binding of l -glutamate ( l -Glu) and l -aspartate ( l -Asp) was measured in rat brain synaptic plasma membranes (SPMs). A distinction between the binding sites for these amino acids was made on the basis of the kinetics, ion eff
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f26141c098447753e57a2a2787eff510
https://doi.org/10.1016/0006-8993(81)90765-4
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