Antiparkinsonian activity of new N-methyl-D-aspartate receptor ligands in the arecoline hyperkinesis test

Autor: V. D. Dergachev, E. E. Yakovleva, M. A. Brusina, E. R. Bychkov, L. B. Piotrovskiy, P. D. Shabanov

Publikováno v: Медицинский совет, Vol 0, Iss 12, Pp 406-412 (2021)

Introduction. Parkinson’s disease (PD) is one of the most common neurodegenerative diseases in the population of older patients. Even though long-term combination therapy helps to cope with the main manifestations of PD. It inevitably leads to the

Externí odkaz: https://doaj.org/article/1f9794bce8634f02b85e101099ab5e99

Comparison of the Anticonvulsant Activities of Substituted Hydroxycoumarins and 4-[(3-Nitro-2-Oxo-2H-Chromen-4-Yl)Amino]Butanoic Acid

Autor: P. D. Shabanov, E. E. Yakovleva, L. V. Myznikov

Publikováno v: Pharmaceutical Chemistry Journal. 54:904-908

The anticonvulsant activity of hydroxycoumarin derivatives and 4-[(3-nitro-2-oxo-2H-chromen-4-yl)amino] butanoic acid was studied using nicotine and corazole convulsion models. All investigated compounds protected animals from death in 100% of cases

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c26678b0313063bf5f0d0772344c8122
https://doi.org/10.1007/s11094-020-02294-9

Synthesis and Pharmacological Activity of 2-(Diethylamino)Ethyl 9-Hydroxy-9H-Fluorene-9-Carboxylate Hydrochloride

Autor: L. K. Khnychenko, E. E. Yakovleva

Publikováno v: Pharmaceutical Chemistry Journal. 53:216-219

New fluorenecarboxylic acid derivatives (structural analogs of amizil) were synthesized. A compound with low toxicity (LD50 = 45 ± 9.9 mg/kg) and antidepressant and antianxiety effects was identified. The central and peripheral muscarinic anticholin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ad805424c5f4cccadb839901c8b1b5f2
https://doi.org/10.1007/s11094-019-01982-5

Enhanced brain penetration of hexamethonium in complexes with derivatives of fullerene C60

Autor: A. Yu. Bespalov, D. N. Nikolaev, E. E. Yakovleva, L. B. Piotrovskiy, E. V. Litasova, Olga A. Dravolina, M. A. Dumpis

Publikováno v: Doklady. Biochemistry and biophysics. 468(1)

The present report describes development of hexamethonium complexes based on fullerene C60. Hexamethonium has a limited penetration into CNS and therefore can antagonize central effects of nicotine only when given at high doses. In the present studie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1e7daedc29f2bb490190f3b17b17bc4
https://pubmed.ncbi.nlm.nih.gov/27417712

Chromatographic and adsorption properties of poly(1-trimethylsilyl-1-propyne) and their stabilization by adding poly(1-phenyl-1-propyne).

Autor: Belotserkovskaya V; Boreskov Institute of Catalysis, Siberian Branch, Russian Academy of Sciences, Prospekt Lavrent'eva 5, 630090 Novosibirsk, Russia. belotserkovskaya.vera@gmail.com, Yakovleva E

Publikováno v: Journal of chromatography. A [J Chromatogr A] 2013 Jul 12; Vol. 1298, pp. 109-17. Date of Electronic Publication: 2013 May 21.