Výsledky vyhledávání - "E. E. S. Nieuwenhuis"

Akademický článek

Mutation-specific reporter for optimization and enrichment of prime editing

Autor: I. F. Schene, I. P. Joore, J. H. L. Baijens, R. Stevelink, G. Kok, S. Shehata, E. F. Ilcken, E. C. M. Nieuwenhuis, D. P. Bolhuis, R. C. M. van Rees, S. A. Spelier, H. P. J. van der Doef, J. M. Beekman, R. H. J. Houwen, E. E. S. Nieuwenhuis, S. A. Fuchs

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)

While prime editing is a promising technique, some genomic sites remain difficult to edit. Here the authors present fluoPEER, fluorescent prime editing and enrichment reporter, to rank the efficiency of pegRNAs and prime editor variants.

Externí odkaz: https://doaj.org/article/ff29147a3c594221b358c3489445515b

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Mutation-specific reporter for optimization and enrichment of prime editing

Autor: I F, Schene, I P, Joore, J H L, Baijens, R, Stevelink, G, Kok, S, Shehata, E F, Ilcken, E C M, Nieuwenhuis, D P, Bolhuis, R C M, van Rees, S A, Spelier, H P J, van der Doef, J M, Beekman, R H J, Houwen, E E S, Nieuwenhuis, S A, Fuchs

Publikováno v: Nature communications. 13(1)

Prime editing is a versatile genome-editing technique that shows great promise for the generation and repair of patient mutations. However, some genomic sites are difficult to edit and optimal design of prime-editing tools remains elusive. Here we pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fedb96c3526e13d90c5590f281da1e4e
https://pubmed.ncbi.nlm.nih.gov/35232966

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[Systematic detection of physical child abuse at emergency rooms]

Autor: J S, Sittig, C S P M, Uiterwaal, K G M, Moons, I M B, Russel, R A J, Nievelstein, E E S, Nieuwenhuis, E M, van de Putte

Publikováno v: Nederlands tijdschrift voor geneeskunde. 160

The aim of our diagnostic accuracy study Child Abuse Inventory at Emergency Rooms (CHAIN-ER) was to establish whether a widely used checklist accurately detects or excludes physical abuse among children presenting to ERs with physical injury.A large

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9a1445b3d24ced8def1872d49162e1b9
https://pubmed.ncbi.nlm.nih.gov/27848908

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Meta-analysis: Inosine triphosphate pyrophosphatase polymorphisms and thiopurine toxicity in the treatment of inflammatory bowel disease

Autor: J M, Van Dieren, B E, Hansen, E J, Kuipers, E E S, Nieuwenhuis, C J, Van der Woude

Publikováno v: Alimentary pharmacologytherapeutics. 26(5)

Thiopurines are widely used for the treatment of inflammatory bowel disease, but are associated with the development of side effects. It has been suggested that the enzyme inosine triphosphate pyrophosphatase (ITPA) plays a role in the digestion of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::609d99a8eca5032597601aec1bf80219
https://pubmed.ncbi.nlm.nih.gov/17697198

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[Bladder control in 1-4 year old children in the the Eindhoven and Kempen region (The Netherlands) in 1996 and 1966]

Autor: B E, Horstmanshoff, G J K, Regterschot, E E S, Nieuwenhuis, M A, Benninga, W, Verwijs, J J J, Waelkens

Publikováno v: Nederlands tijdschrift voor geneeskunde. 147(1)

To determine the age at which children gain bladder control and to compare this with the data from 30 years ago.Questionnaires.On the basis of the findings of a 1966 study into toilet training in the Eindhoven and de Kempen region, the Netherlands, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::eebb413b7fa605fb37bb4dad51b52e3c
https://pubmed.ncbi.nlm.nih.gov/12564295

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