Zobrazeno 1 - 10
of 14
pro vyhledávání: '"E. E. Beedle"'
Autor:
R.R. Lawson, David W. Robertson, B D Potts, J D Leander, Joseph H. Krushinski, Parli Cj, E. E. Beedle
Publikováno v:
Journal of Medicinal Chemistry. 34:1253-1257
The 4-aminobenzamides have provided several anticonvulsants that have been extensively investigated. Ameltolide, 4-amino-N-(2,6-dimethylphenyl)benzamide (compound 2,LY201116), is the most potent analogue studied to date. This drug is inactivated in v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcc2a3d5e71957e430b44839879c867f
https://doi.org/10.1021/jm00108a003
https://doi.org/10.1021/jm00108a003
Autor:
Dennis Charles Thompson, Frank P. Bymaster, Louise Wallace, E. E. Beedle, David W. Robertson, Peter Thaddeus Gallagher, Stephen N. Mitchell, J. H. Krushinski, David T. Wong, Jeremy Findlay
Publikováno v:
Bioorganicmedicinal chemistry letters. 13(24)
A series of naphthalenyloxy-arylpropylamines have been prepared and are demonstrated to be inhibitors of both serotonin and norepinephrine reuptake. One member of this series, duloxetine (Cymbalta) has proven to be effective in clinical trials for th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9047f6380da276771c6308edbf0c6b14
https://pubmed.ncbi.nlm.nih.gov/14643350
https://pubmed.ncbi.nlm.nih.gov/14643350
Publikováno v:
European Journal of Pharmacology. 183:601-602
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6aa22b926e722d02cbfe565a4249745
https://doi.org/10.1016/0014-2999(90)93521-q
https://doi.org/10.1016/0014-2999(90)93521-q
Publikováno v:
Journal of Medicinal Chemistry. 31:1290-1295
Procainamide is a widely used antiarrhythmic that is fraught with therapeutic limitations such as a short half-life, production of autoimmune antibodies and a lupus-like syndrome, and complex pharmacokinetics. We synthesized the congeners of procaina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cc8968f4ee1c8b78062dbe0a82f2350
https://doi.org/10.1021/jm00402a006
https://doi.org/10.1021/jm00402a006
Autor:
J. H. Krushinski, R. C. Rathbun, David T. Wong, J D Leander, David W. Robertson, E. E. Beedle
Publikováno v:
Journal of Medicinal Chemistry. 29:1577-1586
A recently discovered and structurally distinct class of antiepileptic drugs is the (arylalkyl)imidazoles. Two independently discovered representatives of this class, denzimol (alpha-[4-(2-phenylethyl)phenyl]-1H-imidazole-1-ethanol) and nafimidone (2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd9048811e0de9fb9e0a93e5ca63b2f7
https://doi.org/10.1021/jm00159a004
https://doi.org/10.1021/jm00159a004
Autor:
H. Wilson, R. F. Kauffman, Hayes Js, T. K. Elzey, E. E. Beedle, John K. Swartzendruber, David W. Robertson, Noel D. Jones
Publikováno v:
Journal of Medicinal Chemistry. 29:635-640
The cardiotonic drug milrinone (1,6-dihydro-2-methyl-6-oxo-[3,4'-bipyridine]-5-carbonitrile) is superior to its analogue amrinone (5-amino-[3,4'-bipyridin]-6(1H)-one) by virtue of its greater potency and reduced side effect profile. We confirmed init
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af426c8d73113421ebba957daa4d93ec
https://doi.org/10.1021/jm00155a009
https://doi.org/10.1021/jm00155a009
Autor:
David W. Robertson, H. Wilson, E. E. Beedle, Hayes Js, G. D. Pollock, J. H. Krushinski, V. L. Wyss
Publikováno v:
Journal of medicinal chemistry. 28(6)
Recently several noncatecholamine, nonglycoside cardiotonic drugs have been discovered that possess both inotropic and vasodilator activities in experimental animals and man. Prototypical compounds include amrinone, sulmazole, and fenoximone. We inve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75e72a9c27246f6af9d5c4728528decb
https://pubmed.ncbi.nlm.nih.gov/4009593
https://pubmed.ncbi.nlm.nih.gov/4009593
Publikováno v:
Journal of medicinal chemistry. 30(10)
Compound 2 [4-amino-N-(2,6-dimethylphenyl)benzamide] is an effective anticonvulsant in several animal models. For example, following oral administration to mice, it antagonized maximal electroshock (MES) induced seizures with an ED50 of 1.7 mg/kg. Du
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::975e9d109909e4faafc3d9864a1aeae6
https://pubmed.ncbi.nlm.nih.gov/3656350
https://pubmed.ncbi.nlm.nih.gov/3656350
Publikováno v:
Journal of medicinal chemistry. 30(5)
The [(biphenylyloxy)alkyl]imidazoles were found to be potent anticonvulsants. The most potent compound of the series, 1-[2- ([1,1'-biphenyl]-2-yloxy)ethyl]-1H-imidazole (4), had an ED50 of 15.5 mg/kg against maximal-electroshock-induced seizures in m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f503b95b76a02000d0578f02e7f89800
https://pubmed.ncbi.nlm.nih.gov/3572983
https://pubmed.ncbi.nlm.nih.gov/3572983
Autor:
E. E. Beedle, G. D. Pollock, David W. Robertson, Hayes Js, V. L. Wyss, H. Wilson, J. H. Krushinski
Publikováno v:
Chemischer Informationsdienst. 16
Recently several noncatecholamine, nonglycoside cardiotonic drugs have been discovered that possess both inotropic and vasodilator activities in experimental animals and man. Prototypical compounds include amrinone, sulmazole, and fenoximone. We inve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee1759bc7be4b07e22c8ecd622097f6b
https://doi.org/10.1002/chin.198544198
https://doi.org/10.1002/chin.198544198