Zobrazeno 1 - 10
of 267
pro vyhledávání: '"E. Diolaiti"'
Autor:
Taha Y Taha, Rahul K Suryawanshi, Irene P Chen, Galen J Correy, Maria McCavitt-Malvido, Patrick C O'Leary, Manasi P Jogalekar, Morgan E Diolaiti, Gabriella R Kimmerly, Chia-Lin Tsou, Ronnie Gascon, Mauricio Montano, Luis Martinez-Sobrido, Nevan J Krogan, Alan Ashworth, James S Fraser, Melanie Ott
Publikováno v:
PLoS Pathogens, Vol 19, Iss 8, p e1011614 (2023)
Despite unprecedented efforts, our therapeutic arsenal against SARS-CoV-2 remains limited. The conserved macrodomain 1 (Mac1) in NSP3 is an enzyme exhibiting ADP-ribosylhydrolase activity and a possible drug target. To determine the role of Mac1 cata
Externí odkaz:
https://doaj.org/article/389ee82ba53647589bf5956389b4ea8e
Autor:
Taha Y. Taha, Rahul K. Suryawanshi, Irene P. Chen, Galen J. Correy, Patrick C. O’Leary, Manasi P. Jogalekar, Maria McCavitt-Malvido, Morgan E. Diolaiti, Gabriella R. Kimmerly, Chia-Lin Tsou, Luis Martinez-Sobrido, Nevan J. Krogan, Alan Ashworth, James S. Fraser, Melanie Ott
Publikováno v:
bioRxiv
Despite unprecedented efforts, our therapeutic arsenal against SARS-CoV-2 remains limited. The conserved macrodomain 1 (Mac1) in NSP3 is an enzyme exhibiting ADP-ribosylhydrolase activity and a possible drug target. To determine the therapeutic poten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8197d088d3f7b4343977c88a4c32d846
https://europepmc.org/articles/PMC10153184/
https://europepmc.org/articles/PMC10153184/
Autor:
Alan Ashworth, Minkyu Kim, Nevan J. Krogan, Ajda Rojc, Patrick C. O'Leary, Morgan E. Diolaiti, Huadong Chen
Inhibitors directed toward PARP1 and PARP2 are approved agents for the treatment of BRCA1 and BRCA2-related cancers. Other members of the PARP family have also been implicated in cancer and are being assessed as therapeutic targets in cancer and othe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::502e22b48743fe29f10e42c42957fea0
https://doi.org/10.1158/1535-7163.c.6543442.v1
https://doi.org/10.1158/1535-7163.c.6543442.v1
Autor:
Alan Ashworth, Minkyu Kim, Nevan J. Krogan, Ajda Rojc, Patrick C. O'Leary, Morgan E. Diolaiti, Huadong Chen
Supplementary Table from A Whole-Genome CRISPR Screen Identifies AHR Loss as a Mechanism of Resistance to a PARP7 Inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0223527726cd3bd69b54030729b8e944
https://doi.org/10.1158/1535-7163.22522588.v1
https://doi.org/10.1158/1535-7163.22522588.v1
Autor:
Alan Ashworth, Minkyu Kim, Nevan J. Krogan, Ajda Rojc, Patrick C. O'Leary, Morgan E. Diolaiti, Huadong Chen
Supplementary Data from A Whole-Genome CRISPR Screen Identifies AHR Loss as a Mechanism of Resistance to a PARP7 Inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08c89414f20cecb8e1e4809d6fb58403
https://doi.org/10.1158/1535-7163.22522606.v1
https://doi.org/10.1158/1535-7163.22522606.v1
Autor:
Daniel V. Santi, Yves Pommier, Minh Nguyen, Gary W. Ashley, Felix Y. Feng, Alan Ashworth, Samantha Nichols, Linda Sciuto, Nobuyuki Takahashi, Rajesh Kumar, Parth Desai, Morgan E. Diolaiti, Shaun D. Fontaine, Anish Thomas
Supplementary Data from PLX038: A Long-Acting Topoisomerase I Inhibitor With Robust Antitumor Activity in ATM-Deficient Tumors and Potent Synergy With PARP Inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2283b46761b5c690e2227e7bb9af891c
https://doi.org/10.1158/1535-7163.22523526
https://doi.org/10.1158/1535-7163.22523526
Autor:
Alan Ashworth, Morgan E. Diolaiti, Minkyu Kim, Nevan J. Krogan, Danielle L. Swaney, Felix Y. Feng, Jonathan Chou, David A. Quigley, Erica Stevenson, Julia Carnevale, Nupura Kale, Tanushree Shenoy, Andrew S. McNeal, Benjamin Polacco, Tess Williamson, Yagmur U. Doruk, Huadong Chen, Patrick C. O'Leary
Supplementary Data from Resistance to ATR Inhibitors Is Mediated by Loss of the Nonsense-Mediated Decay Factor UPF2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92986e26882662aa61f7f7e58431704b
https://doi.org/10.1158/0008-5472.22431791.v1
https://doi.org/10.1158/0008-5472.22431791.v1
Autor:
Alan Ashworth, Morgan E. Diolaiti, Minkyu Kim, Nevan J. Krogan, Danielle L. Swaney, Felix Y. Feng, Jonathan Chou, David A. Quigley, Erica Stevenson, Julia Carnevale, Nupura Kale, Tanushree Shenoy, Andrew S. McNeal, Benjamin Polacco, Tess Williamson, Yagmur U. Doruk, Huadong Chen, Patrick C. O'Leary
Over one million cases of gastric cancer are diagnosed each year globally, and the metastatic disease continues to have a poor prognosis. A significant proportion of gastric tumors have defects in the DNA damage response pathway, creating therapeutic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e2efdac4937d30e0166c30b8ebc596f
https://doi.org/10.1158/0008-5472.c.6513989
https://doi.org/10.1158/0008-5472.c.6513989
Autor:
Alan Ashworth, Morgan E. Diolaiti, Minkyu Kim, Nevan J. Krogan, Danielle L. Swaney, Felix Y. Feng, Jonathan Chou, David A. Quigley, Erica Stevenson, Julia Carnevale, Nupura Kale, Tanushree Shenoy, Andrew S. McNeal, Benjamin Polacco, Tess Williamson, Yagmur U. Doruk, Huadong Chen, Patrick C. O'Leary
Supplementary Figure from Resistance to ATR Inhibitors Is Mediated by Loss of the Nonsense-Mediated Decay Factor UPF2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aea259a0a3d08bae39c797d8f8597da
https://doi.org/10.1158/0008-5472.22431788.v1
https://doi.org/10.1158/0008-5472.22431788.v1
Autor:
Susan D. Mertins, Natalie M. Isenberg, Kristofer-Roy Reyes, Byung-Jun Yoon, Nathan Urban, Manasi P. Jogalekar, Morgan E. Diolaiti, M. Ryan Weil, Eric A. Stahlberg
Pharmacodynamic models provide inroads to understanding key mechanisms of action and may significantly improve patient outcomes in cancer with improved ability to determine therapeutic benefit. Additionally, these models may also lead to insights int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67dd540737e687148820e57e811dca38
https://doi.org/10.1101/2023.02.08.527527
https://doi.org/10.1101/2023.02.08.527527