Common Variants at 9p21 and 8q22 Are Associated with Increased Susceptibility to Optic Nerve Degeneration in Glaucoma

Autor: Brian L. Yaspan, Robert N. Weinreb, Douglas E. Gaasterland, Stephanie Loomis, Kristy Crooks, Tomohiro Masuda, David S. Friedman, Daniel B. Mirel, Jason Ernst, Joel S. Schuman, Kathleen M. Scott, Joshua D. Stein, Wael Abdrabou, Sayoko E. Moroi, Cathy C. Laurie, Paul R. Lichter, Margaret A. Pericak-Vance, Catherine A. McCarty, Gadi Wollstein, Anthony Realini, Felipe A. Medeiros, Richard K. Lee, Jae H. Kang, Louis R. Pasquale, Sachiko Yoneyama, Frank W. Rozsa, R. Rand Allingham, Kuldev Singh, Yutao Liu, Julia E. Richards, E. DelBono, Wendy Brodeur, David C. Musch, Manolis Kellis, Baojian Fan, Donald L. Budenz, Edward H. Trager, Jonathan L. Haines, Kang Zhang, Donald J. Zack, Janey L. Wiggs, Dan Y. Wang, Kimberly F. Doheny, Joseph Caprioli, Andrew Crenshaw, Paul C. VanVeldhuisen, Terry Gaasterland, Douglas Vollrath, Michael A. Hauser, Lana M. Olson

Publikováno v: PLoS
PLoS genetics, vol 8, iss 4
PLoS Genetics, Vol 8, Iss 4, p e1002654 (2012)
PLoS Genetics
Wiggs, JL; Yaspan, BL; Hauser, MA; Kang, JH; Allingham, RR; Olson, LM; et al.(2012). Common variants at 9p21 and 8q22 are associated with increased susceptibility to optic nerve degeneration in glaucoma. PLoS Genetics, 8(4). doi: 10.1371/journal.pgen.1002654. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/29k3w68p

Optic nerve degeneration caused by glaucoma is a leading cause of blindness worldwide. Patients affected by the normal-pressure form of glaucoma are more likely to harbor risk alleles for glaucoma-related optic nerve disease. We have performed a meta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a1c998928b3b7f3126d174e0836d4b4
http://hdl.handle.net/1721.1/71760

Distribution of optineurin sequence variations in an ethnically diverse population of low-tension glaucoma patients from the United States

Autor: Janey L. Wiggs, Felicia L. Graham, J. Auguste, R. Rand Allingham, Dayse F Sena, Margaret A. Pericak-Vance, E. DelBono, Jason D. Flor, Jeff Walter, Jonathan L. Haines, Michael A. Hauser, Karen LaRocque-Abramson

Publikováno v: Journal of glaucoma. 15(5)

Previous studies have suggested that Optineurin (OPTN) sequence variants contribute to low-tension glaucoma (LTG) in ethnically homogeneous populations. The purpose of this study is to evaluate the prevalence of OPTN sequence variants in an ethnicall

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f5c1c96d1878f2e01d6c04e67f6e14d
https://pubmed.ncbi.nlm.nih.gov/16988596

A Gene Responsible for the Pigment Dispersion Syndrome Maps to Chromosome 7q35-q36

Autor: E. DelBono, Joel S. Schuman, Anca M. Pralea, Jessica S. Andersen, Cynthia Mattox, Janey L. Wiggs, J. L. Haines, Michael B. Gorin

Publikováno v: Archives of Ophthalmology. 115:384

Objectives: To demonstrate the inheritance of the pigment dispersion syndrome in 4 families and to determine the location of a gene responsible for this syndrome. Patients: Fifty-four members of 4 families affected by the pigment dispersion syndrome

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b24506b36cea187811a8d5489526e7b7
https://doi.org/10.1001/archopht.1997.01100150386012

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