In vivo detection of amyloid-β deposits using heavy chain antibody fragments in a transgenic mouse model for Alzheimer's disease.

Autor: Rob J A Nabuurs, Kim S Rutgers, Mick M Welling, Athanasios Metaxas, Maaike E de Backer, Maarten Rotman, Brian J Bacskai, Mark A van Buchem, Silvère M van der Maarel, Louise van der Weerd

Publikováno v: PLoS ONE, Vol 7, Iss 6, p e38284 (2012)

This study investigated the in vivo properties of two heavy chain antibody fragments (V(H)H), ni3A and pa2H, to differentially detect vascular or parenchymal amyloid-β deposits characteristic for Alzheimer's disease and cerebral amyloid angiopathy.

Externí odkaz: https://doaj.org/article/345936b88cb54209aa94fbd068f64428

Bis-pyridylethenyl benzene as novel backbone for amyloid-beta binding compounds

Autor: Louise van der Weerd, Albert D. Windhorst, Athanasios Metaxas, Mark Overhand, Mick M. Welling, Sarah Hafith, Wim Jiskoot, Rob J.A. Nabuurs, Adrianus M. C. H. van den Nieuwendijk, Maaike E. de Backer, Varsha V. Kapoerchan, Herman S. Overkleeft, Mark A. van Buchem

Publikováno v: Bioorganic and Medicinal Chemistry, 24(23), 6139-6148
Bioorganic and Medicinal Chemistry, 24(23), 6139-6148. Elsevier Limited
Nabuurs, R J A, Kapoerchan, V V, Metaxas, A, Hafith, S, de Backer, M, Welling, M M, Jiskoot, W, van den Nieuwendijk, A M C H, Windhorst, A D, Overkleeft, H S, van Buchem, M A, Overhand, M & van der Weerd, L 2016, ' Bis-pyridylethenyl benzene as novel backbone for amyloid-β binding compounds ', Bioorganic and Medicinal Chemistry, vol. 24, no. 23, pp. 6139-6148 . https://doi.org/10.1016/j.bmc.2016.05.022

Detection of cerebral β-amyloid (Aβ) by targeted contrast agents is of great interest for in vivo diagnosis of Alzheimer's disease (AD). Partly because of their planar structure several bis-styrylbenzenes have been previously reported as potential

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::365063b4bf0a0ae018a5ea2bd3be16bd
http://hdl.handle.net/1887/112175

A 1024-QAM Analog Front-End for Broadband Powerline Communication Up to 60 MHz

Autor: Guy Torfs, Peter Ossieur, Jan Vandewege, J. Bauwelinck, Xing-Zhi Qiu, C. Melange, E. De Backer, S. Horvath

Publikováno v: IEEE Journal of Solid-State Circuits. 44:1477-1485

A high performance analog front-end (AFE) for broadband powerline communication between 1.6 and 60 MHz is presented. The frequency division multiplexing AFE supports optimum channel selection, avoids disturbing RF signals and allows co-existence with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8ecba39595a67ed78160041560ede1ca
https://doi.org/10.1109/jssc.2009.2017008

MIMC reliability and electrical behavior defined by a physical layer property of the dielectric

Autor: Patrick Bogaert, B. Vlachakis, A. Iline, Rémy Charavel, E. De Backer, K. Dhondt, M. Millecam, L. De Schepper, J. Ackaert, Jean-Pierre Raskin, Alexandru Vlad, E. Vandevelde

Publikováno v: Microelectronics Reliability. 48:1553-1556

Metal-insulator-metal capacitor (MIMC) reliability and electrical properties are defined by the TDDB lifetime. breakdown voltage and leakage current. In this article, the correlation is determined between these electrical properties and the physical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1b6f13fa3d099298aa806b89aa733ea6
https://doi.org/10.1016/j.microrel.2008.06.043

Enhanced glutathione PEGylated liposomal brain delivery of an anti-amyloid single domain antibody fragment in a mouse model for Alzheimer's disease

Autor: Maarten Rotman, Maaike E. de Backer, Mick M. Welling, Anton Bunschoten, Silvère M. van der Maarel, Jaap Rip, Louise van der Weerd, Mark A. van Buchem, Pieter J. Gaillard, Rob J.A. Nabuurs

Publikováno v: Journal of Controlled Release, 203, 40-50

Treatment of neurodegenerative disorders such as Alzheimer's disease is hampered by the blood-brain barrier (BBB). This tight cerebral vascular endothelium regulates selective diffusion and active transport of endogenous molecules and xenobiotics int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3a8fd285552d2e94c8ac5775020490b
https://hdl.handle.net/1887/101871