Zobrazeno 1 - 10
of 95
pro vyhledávání: '"E. D. Saggerson"'
Autor:
E D Saggerson, Nigel Turner, Graeme M. Birdsey, N. M. Broadway, Majid Shayeghi, Richard J. Pease
Publikováno v:
Biochemical Society Transactions. 29:267-271
Liver microsomes contain two carnitine acyltransferase activities. One of these has properties closely corresponding to those of 88 kDa mitochondrial carnitine palmitoyltransferase-1 (CPT-1). Antisera against CPT-1 cross-react with an 88 kDa microsom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::faef1c28ad1abb9209b1119f0320d8eb
https://doi.org/10.1042/bst0290267
https://doi.org/10.1042/bst0290267
Autor:
Hamilton C, E D Saggerson
Publikováno v:
Biochemical Journal. 350:61-67
(1) Malonyl-CoA is thought to play a signalling role in fuel-selection in cardiac muscle, but the rate at which the concentration of this potential signal can be changed has not previously been investigated. (2) Rapid changes in cellular malonyl-CoA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::683d97d536f40eb507e97e6f842493b3
https://doi.org/10.1042/bj3500061
https://doi.org/10.1042/bj3500061
Publikováno v:
Biochemical Journal. 341:453-460
Clones of HepG2 cells were selected that stably express the cDNA for hormone-sensitive lipase (HSL). When cells were cultured in the presence of labelled extracellular oleate, accumulation of labelled fatty acid as cellular triacylglycerol (TAG) was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3c302a4fd1729858d19f398d8d096cc
https://doi.org/10.1042/bj3410453
https://doi.org/10.1042/bj3410453
Autor:
R D Harper, E D Saggerson, Ph. D.
Publikováno v:
Journal of Lipid Research, Vol 17, Iss 5, Pp 516-526 (1976)
Fat cells isolated from rat epididymal adipose tissue were incubated with albumin-bound [14C]palmitate. Incorporation of 14C into 14CO2 and glycerides was measured. Some evidence is presented to suggest that the exogenous palmitate pool is in isotopi
Externí odkaz:
https://doaj.org/article/ce06b91fa5ed46998b1afdd9387a53ff
Autor:
E D Saggerson, N Alam
Publikováno v:
Biochemical Journal. 334:233-241
1. Rat soleus strips were incubated with 5 mM glucose, after which tissue metabolites were measured. Alternatively, muscle strips were incubated with 5 mM glucose and 0.2 mM palmitate, and the formation of 14CO2 from exogenous palmitate or from fatty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f64420a1812a25b6bae86566e4e4a5e4
https://doi.org/10.1042/bj3340233
https://doi.org/10.1042/bj3340233
Autor:
Eileithyia Swanton, E D Saggerson
Publikováno v:
Biochemical Journal. 328:913-922
Ca2+-tolerant myocytes were isolated with endogenous triacylglycerol (TAG) stores prelabelled with [3H]palmitate and subsequently incubated for a 1 h chase period with [14C]palmitate, 2% albumin and 5 mM glucose. Measurements were then made of [14C]p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6df635ba4dff44a8891d30570faa1a00
https://doi.org/10.1042/bj3280913
https://doi.org/10.1042/bj3280913
Autor:
E. D. Saggerson, Eileithyia Swanton
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism. 1346:93-102
1. The properties and subcellular distribution of phosphatidate phosphohydrolase (PAP) were studied in rat heart. A Mg2(+)-activated activity (PAP1) which was inhibited by N-ethylmaleimide was found mainly in a 105,000 x g soluble fraction. Isolation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a16e0aa4aae6ecaa62cca311d7c620e1
https://doi.org/10.1016/s0005-2760(97)00024-6
https://doi.org/10.1016/s0005-2760(97)00024-6
Autor:
E D Saggerson, N. M. Broadway
Publikováno v:
Biochemical Journal. 322:435-440
We have investigated the extent to which membrane environment affects the catalytic properties of the malonyl-CoA-sensitive carnitine acyltransferase of liver microsomal membranes. Arrhenius-type plots of activity were linear in the absence and prese
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b28a9449ad2c950fd4f75ac3fbd760b3
https://doi.org/10.1042/bj3220435
https://doi.org/10.1042/bj3220435
Autor:
N. M. Broadway, E D Saggerson
Publikováno v:
Biochemical Journal. 310:989-995
Conditions have been developed for the solubilization of hepatic microsomal carnitine acyltransferase activity in good yield, with excellent long-term stability and with retention of malonyl-CoA sensitivity. Solubilized microsomal carnitine acyltrans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad097385ad3c035806b3a393984321e7
https://doi.org/10.1042/bj3100989
https://doi.org/10.1042/bj3100989
Autor:
E D Saggerson, Z Jamal
Publikováno v:
Biochemical Journal. 269:157-161
1. White adipocytes were found to be more responsive than brown adipocytes to inhibition of lipolysis by the A1 adenosine receptor agonist phenylisopropyladenosine. 2. Radioligand binding studies with plasma membranes isolated from the two adipocyte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fccc15c65e41fdf14f2d1cfb3a7b877
https://doi.org/10.1042/bj2690157
https://doi.org/10.1042/bj2690157